Open Access

Mast cell‑mediated neuroinflammation may have a role in attention deficit hyperactivity disorder (Review)

  • Authors:
    • Yuchen Song
    • Manqi Lu
    • Haixia Yuan
    • Tianyi Chen
    • Xinmin Han
  • View Affiliations

  • Published online on: May 25, 2020     https://doi.org/10.3892/etm.2020.8789
  • Pages: 714-726
  • Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental and behavioral disorder with a serious negative impact on the quality of life from childhood until adulthood, which may cause academic failure, family disharmony and even social unrest. The pathogenesis of ADHD has remained to be fully elucidated, leading to difficulties in the treatment of this disease. Genetic and environmental factors contribute to the risk of ADHD development. Certain studies indicated that ADHD has high comorbidity with allergic and autoimmune diseases, with various patients with ADHD having a high inflammatory status. Increasing evidence indicated that mast cells (MCs) are involved in the pathogenesis of brain inflammation and neuropsychiatric disorders. MCs may cause or aggravate neuroinflammation via the selective release of inflammatory factors, interaction with glial cells and neurons, activation of the hypothalamic‑pituitary adrenal axis or disruption of the blood‑brain barrier integrity. In the present review, the notion that MC activation may be involved in the occurrence and development of ADHD through a number of ways is discussed based on previously published studies. The association between MCs and ADHD appears to lack sufficient evidence at present and this hypothesis is considered to be worthy of further study, providing a novel perspective for the treatment of ADHD.

Related Articles

Journal Cover

August-2020
Volume 20 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Song Y, Lu M, Yuan H, Chen T and Han X: Mast cell‑mediated neuroinflammation may have a role in attention deficit hyperactivity disorder (Review). Exp Ther Med 20: 714-726, 2020
APA
Song, Y., Lu, M., Yuan, H., Chen, T., & Han, X. (2020). Mast cell‑mediated neuroinflammation may have a role in attention deficit hyperactivity disorder (Review). Experimental and Therapeutic Medicine, 20, 714-726. https://doi.org/10.3892/etm.2020.8789
MLA
Song, Y., Lu, M., Yuan, H., Chen, T., Han, X."Mast cell‑mediated neuroinflammation may have a role in attention deficit hyperactivity disorder (Review)". Experimental and Therapeutic Medicine 20.2 (2020): 714-726.
Chicago
Song, Y., Lu, M., Yuan, H., Chen, T., Han, X."Mast cell‑mediated neuroinflammation may have a role in attention deficit hyperactivity disorder (Review)". Experimental and Therapeutic Medicine 20, no. 2 (2020): 714-726. https://doi.org/10.3892/etm.2020.8789