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Population pharmacokinetics model and initial dose optimization of tacrolimus in children and adolescents with lupus nephritis based on real‑world data

  • Authors:
    • Xiao Chen
    • Dong‑Dong Wang
    • Hong Xu
    • Zhi‑Ping Li
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Children's Hospital of Fudan University, Shanghai 201102, P.R. China, Department of Nephrology, Children's Hospital of Fudan University, Shanghai 201102, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1423-1430
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    Published online on: May 30, 2020
       https://doi.org/10.3892/etm.2020.8821
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Abstract

The present study aimed to establish a population pharmacokinetics model of tacrolimus and further optimize the initial dosing regimen of tacrolimus in pediatric and adolescent patients with lupus nephritis (LN). Pediatric and adolescent patients with LN were recruited between August 2014 and September 2019 at the Children's Hospital of Fudan University (Shanghai, China). Relevant information was used to set up a population pharmacokinetics model with a Nonlinear Mixed Effect Model and the initial dosage regimen was simulated with the Monte Carlo method. Body weight and co‑administration of wuzhi capsule were indicated to influence tacrolimus clearance in pediatric and adolescent patients with LN, and at the same body weight, the rate of tacrolimus clearance in patients without vs. with co‑administration of wuzhi capsule was 1:0.71. In addition, in patients who were not administered wuzhi capsule, an initial dosage regimen of 0.15 mg/kg/day was recommended for a body weight of 10‑23 kg and 0.10 mg/kg/day for 23‑60 kg; in patients who were administered wuzhi capsule, an initial dosage regimen of 0.10 mg/kg/day was recommended for a body weight of 10‑23 kg and 0.05 mg/kg/day for 23‑60 kg. To the best of our knowledge, the present study was the first to establish a population pharmacokinetics model of tacrolimus in order to determine the optimal initial dosage regimen of tacrolimus in pediatric and adolescent patients with LN.
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Copy and paste a formatted citation
Spandidos Publications style
Chen X, Wang DD, Xu H and Li ZP: Population pharmacokinetics model and initial dose optimization of tacrolimus in children and adolescents with lupus nephritis based on real‑world data. Exp Ther Med 20: 1423-1430, 2020.
APA
Chen, X., Wang, D., Xu, H., & Li, Z. (2020). Population pharmacokinetics model and initial dose optimization of tacrolimus in children and adolescents with lupus nephritis based on real‑world data. Experimental and Therapeutic Medicine, 20, 1423-1430. https://doi.org/10.3892/etm.2020.8821
MLA
Chen, X., Wang, D., Xu, H., Li, Z."Population pharmacokinetics model and initial dose optimization of tacrolimus in children and adolescents with lupus nephritis based on real‑world data". Experimental and Therapeutic Medicine 20.2 (2020): 1423-1430.
Chicago
Chen, X., Wang, D., Xu, H., Li, Z."Population pharmacokinetics model and initial dose optimization of tacrolimus in children and adolescents with lupus nephritis based on real‑world data". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1423-1430. https://doi.org/10.3892/etm.2020.8821
Copy and paste a formatted citation
x
Spandidos Publications style
Chen X, Wang DD, Xu H and Li ZP: Population pharmacokinetics model and initial dose optimization of tacrolimus in children and adolescents with lupus nephritis based on real‑world data. Exp Ther Med 20: 1423-1430, 2020.
APA
Chen, X., Wang, D., Xu, H., & Li, Z. (2020). Population pharmacokinetics model and initial dose optimization of tacrolimus in children and adolescents with lupus nephritis based on real‑world data. Experimental and Therapeutic Medicine, 20, 1423-1430. https://doi.org/10.3892/etm.2020.8821
MLA
Chen, X., Wang, D., Xu, H., Li, Z."Population pharmacokinetics model and initial dose optimization of tacrolimus in children and adolescents with lupus nephritis based on real‑world data". Experimental and Therapeutic Medicine 20.2 (2020): 1423-1430.
Chicago
Chen, X., Wang, D., Xu, H., Li, Z."Population pharmacokinetics model and initial dose optimization of tacrolimus in children and adolescents with lupus nephritis based on real‑world data". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1423-1430. https://doi.org/10.3892/etm.2020.8821
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