Effects of fast‑track anesthesia on miR‑1 and neuropeptides in serum of patients undergoing cardiac surgery

Zhang,Hongxia; Chai,Yongjian; Li,Qinggang; Han,Qingtao; Lv,Zhenqian

doi:10.3892/etm.2020.8823

Effects of fast‑track anesthesia on miR‑1 and neuropeptides in serum of patients undergoing cardiac surgery

Authors:
- Hongxia Zhang
- Yongjian Chai
- Qinggang Li
- Qingtao Han
- Zhenqian Lv
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Affiliations: Department of Anesthesiology, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China, Department of Anesthesiology, First People's Hospital of Jinan, Jinan, Shandong 250000, P.R. China , Medical Department, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China , Interventional Vascular Diseases, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China , Cardiac Surgery, Qingdao Fuwai Cardiovascular Disease Hospital, Qingdao, Shandong 266034, P.R. China
Published online on: May 30, 2020 https://doi.org/10.3892/etm.2020.8823
Pages: 1480-1486
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Effects of fast‑track anesthesia (FTA) on miR‑1 and neuropeptides in serum of patients undergoing cardiac surgery were investigated. A total of 147 patients who underwent cardiac surgery at Jining No. 1 people's Hospital from August 2015 to July 2018 were selected. There were 72 patients who received the FTA technology during cardiac surgery in the intervention group, and 75 patients who received routine anesthesia during cardiac surgery in the control group. Venous blood was, respectively, collected before anesthesia (T0), 30 min after artery opening (T1), 60 min after artery opening (T2), and 180 min after artery opening (T3). Expression of serum miR‑1 in patients at T0 to T3 were detected by real‑time fluorescence quantitative PCR. Expression of neuropeptide indexes such as neuron‑specific enolase (NSE), S100β protein (S100β), and amyloid β‑protein (Aβ) in serum of patients in the two groups at T0 to T3 were detected by ELISA, and the correlation of expression of serum miR‑1, serum NSE, S100β and Aβ was analyzed. There was no significant difference in the expression of serum miR‑1 between the two groups at T0 (P>0.05). There was no significant difference in the expression of NSE, S100β and Aβ between the two groups at T0 (P>0.05). Expression of serum NSE, S100β and Aβ in both groups increased gradually, and expression of serum NSE, S100β and Aβ in the intervention group were significantly lower than those in the control group at T1‑T3 (P<0.05). There was a positive correlation between expression of serum miR‑1, serum NSE, S100β and Aβ (r=0.773, P<0.05; r=0.683, P<0.05; r=0.769, P<0.05). Application of the FTA technology in cardiac surgery can effectively reduce the level of serum miR‑1 in patients undergoing surgical treatment and improve their neurological function.

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