Open Access

Collagen triple helix repeat containing 1 promotes endometrial cancer cell migration by activating the focal adhesion kinase signaling pathway

  • Authors:
    • Xiang Hu
    • Yiding Bian
    • Xiaoli Wen
    • Mengfei Wang
    • Yiran Li
    • Xiaoping Wan
  • View Affiliations

  • Published online on: June 4, 2020     https://doi.org/10.3892/etm.2020.8833
  • Pages: 1405-1414
  • Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Metastasis of endometrial cancer (EC) is known to be the major cause of relapse and death of patients. However, the mechanisms of this process are not well understood. Focal adhesion kinase (FAK) is known for its essential role in integrin signaling and is highly expressed in many human tumors. FAK also plays important roles in a variety of cellular processes. Collagen triple helix repeat containing 1 (CTHRC1) is a secreted protein that has been detected in many human solid cancers. In the present study, CTHRC1 was found to be highly expressed in EC tissues when compared with normal tissues. In addition, overexpression of CTHRC1 promoted the migration of EC cells in vitro. Recombinant CTHRC1 protein also promoted the migration of EC cells in vitro. The results of the present study suggested that CTHRC1 mediated EC cell migration via the FAK signaling pathway. Taken together, these data indicated that CTHRC1 and the FAK signaling pathway may be potential therapeutic targets for EC metastasis treatment.

Related Articles

Journal Cover

August-2020
Volume 20 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Hu, X., Bian, Y., Wen, X., Wang, M., Li, Y., & Wan, X. (2020). Collagen triple helix repeat containing 1 promotes endometrial cancer cell migration by activating the focal adhesion kinase signaling pathway. Experimental and Therapeutic Medicine, 20, 1405-1414. https://doi.org/10.3892/etm.2020.8833
MLA
Hu, X., Bian, Y., Wen, X., Wang, M., Li, Y., Wan, X."Collagen triple helix repeat containing 1 promotes endometrial cancer cell migration by activating the focal adhesion kinase signaling pathway". Experimental and Therapeutic Medicine 20.2 (2020): 1405-1414.
Chicago
Hu, X., Bian, Y., Wen, X., Wang, M., Li, Y., Wan, X."Collagen triple helix repeat containing 1 promotes endometrial cancer cell migration by activating the focal adhesion kinase signaling pathway". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1405-1414. https://doi.org/10.3892/etm.2020.8833