Open Access

C‑reactive protein and cardiovascular disease: From animal studies to the clinic (Review)

  • Authors:
    • Yu Fu
    • Yi Wu
    • Enqi Liu
  • View Affiliations

  • Published online on: June 4, 2020     https://doi.org/10.3892/etm.2020.8840
  • Pages: 1211-1219
  • Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

C‑reactive protein (CRP) and cardiovascular disease (CVD) have long been important research topics. CRP is an acute phase protein, while CVD is an inflammatory condition. The association between CRP and CVD remains controversial and has been attracting increasing attention. Traditionally, the main marker of CVD is considered to be low‑density lipoprotein cholesterol. However, due to its unique characteristics, CRP may represent a novel marker or a new therapeutic target for CVD. Clinical studies have demonstrated that CRP is a predictor of CVD, but whether it is directly involved in the development and progression of CVD has yet to be fully elucidated. Recent clinical studies have demonstrated that lowering plasma CRP levels may reduce the incidence of CVD. The aim of the present review was to investigate the association between CRP and CVD, particularly atherosclerosis, from laboratory animal studies to clinical research.

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August-2020
Volume 20 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Fu Y, Wu Y and Liu E: C‑reactive protein and cardiovascular disease: From animal studies to the clinic (Review). Exp Ther Med 20: 1211-1219, 2020
APA
Fu, Y., Wu, Y., & Liu, E. (2020). C‑reactive protein and cardiovascular disease: From animal studies to the clinic (Review). Experimental and Therapeutic Medicine, 20, 1211-1219. https://doi.org/10.3892/etm.2020.8840
MLA
Fu, Y., Wu, Y., Liu, E."C‑reactive protein and cardiovascular disease: From animal studies to the clinic (Review)". Experimental and Therapeutic Medicine 20.2 (2020): 1211-1219.
Chicago
Fu, Y., Wu, Y., Liu, E."C‑reactive protein and cardiovascular disease: From animal studies to the clinic (Review)". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1211-1219. https://doi.org/10.3892/etm.2020.8840