Open Access

Acute coronary syndrome with ST segment elevation in a patient with Addison disease: Case report and brief review of physiopathological mechanisms: A case study

  • Authors:
    • Minela Aida Maranduca
    • Cristian Statescu
    • Radu Andy Sascau
    • Nicoleta Dima
    • Loredana Liliana Hurjui
    • Dragomir Nicolae Serban
    • Ionela Lacramioara Serban
  • View Affiliations

  • Published online on: June 10, 2020     https://doi.org/10.3892/etm.2020.8855
  • Pages: 1230-1236
  • Copyright: © Maranduca et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The adrenal gland serve important roles in the modulation of the immune response, the adjustment of blood pressure, the stress reaction via glucocorticoids and the hydroelectrolytic balance via mineralocorticoids. Primary adrenal insufficiency, known as Addison disease, is characterized by a decrease in glucocorticoid secretion (cortisol) and, more rarely, by a hyposecretion of mineralocorticoids (aldosterone). The production of cortisol, which is a hormone that helps the body respond to stress, is regulated in the brain, the hypothalamus and the pituitary gland. The hypothalamus stimulates the pituitary gland to produce adrenocorticotropic hormone, which stimulates cortisol production from the adrenal gland. If left untreated, Addison disease has a high mortality rate. Corticotherapy used in the treatment of Addison disease is associated with a certain cardiovascular risk. The proatherogenic effect of corticoids is based on the chronic inflammatory response of the vascular wall to a series of events. The aim of the current case report was to review the pathophysiological mechanisms and interactions that may lead to the onset of acute coronary syndrome with ST elevation in a patient with Addison disease.

Related Articles

Journal Cover

August-2020
Volume 20 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Maranduca, M.A., Statescu, C., Sascau, R.A., Dima, N., Hurjui, L.L., Serban, D.N., & Serban, I.L. (2020). Acute coronary syndrome with ST segment elevation in a patient with Addison disease: Case report and brief review of physiopathological mechanisms: A case study. Experimental and Therapeutic Medicine, 20, 1230-1236. https://doi.org/10.3892/etm.2020.8855
MLA
Maranduca, M. A., Statescu, C., Sascau, R. A., Dima, N., Hurjui, L. L., Serban, D. N., Serban, I. L."Acute coronary syndrome with ST segment elevation in a patient with Addison disease: Case report and brief review of physiopathological mechanisms: A case study". Experimental and Therapeutic Medicine 20.2 (2020): 1230-1236.
Chicago
Maranduca, M. A., Statescu, C., Sascau, R. A., Dima, N., Hurjui, L. L., Serban, D. N., Serban, I. L."Acute coronary syndrome with ST segment elevation in a patient with Addison disease: Case report and brief review of physiopathological mechanisms: A case study". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1230-1236. https://doi.org/10.3892/etm.2020.8855