Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Changes and clinical significance of serum inflammatory factors in the treatment of pregnancy hypertension syndrome with magnesium sulfate combined with nifedipine

  • Authors:
    • Feifei Zhao
    • Fang Ai
    • Jie Wu
    • Xudong Dong
  • View Affiliations / Copyright

    Affiliations: Obstetrics Department, The First People's Hospital of Yunnan Province (The Affiliated Hospital of Kunming University of Science and Technology), Kunming, Yunnan 650032, P.R. China
  • Pages: 1796-1802
    |
    Published online on: June 10, 2020
       https://doi.org/10.3892/etm.2020.8863
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Curative effect of magnesium sulfate combined with nifedipine on pregnancy‑induced hypertension and the effect of serum inflammatory factors were investigated. A total of 188 cases of patients were collected as the research subjects. They all had pregnancy‑induced hypertension, and were admitted to The First People's Hospital of Yunnan Province hospital from June 2016 to February 2018. There were, 94 patients treated with magnesium sulfate in the control group, and further 94 patients treated with magnesium sulfate combined with nifedipine in the study group. ELISA was used to detect the expression levels of suppressors of cytokine signaling‑3 (SOCS‑3), interleukin‑10 (IL‑10) and interleukin 18 (IL‑18), and the relationship between serum inflammatory factors and efficacy was analyzed. The curative effect and eutocia rate in the study group were significantly higher than those in the control group (P<0.05), and the cesarean section rate was lower than that of the control group (P<0.05). In the study group, the adverse reactions were significantly lower than those in the control group (P<0.05). After treatment, the expression levels of serum SOCS‑3 and IL‑10 in the study group were significantly higher than those in the control group (P<0.05), while the expression level of serum IL‑18 was significantly lower than that in the control group (P<0.05). The area under the curve (AUC) of the predictive value of SOCS‑3, IL‑10 and IL‑18 in pregnancy‑induced hypertension was 0.717, 0.727 and 0.725, respectively. The best specificity was 76.19, 52.98 and 61.90%, respectively, when the cut‑off value was <0.553 ng/l, 48.06 ng/ml and 269.46 ng/ml, and their sensitivity was 70.00, 94.74 and 85.00%, respectively. In conclusion, magnesium sulfate combined with nifedipine significantly improved the disease course of pregnancy‑induced hypertension. The levels of SOCS‑3, IL‑10 and IL‑18 in patients are correlated with the curative effect of pregnancy‑induced hypertension, suggesting that they have important value in the treatment and monitoring of gestational hypertension.
View Figures

Figure 1

Figure 2

View References

1 

George JN and Amaresh A: Neonatal mortality and morbidity in pregnancy induced hypertension: A prospective observational study. J Evol Med Dent Sci. 3:5238–5246. 2014.

2 

Zhuang C, Gao J, Liu J, Wang X, He J, Sun J, Liu X and Liao S: Risk factors and potential protective factors of pregnancy-induced hypertension in China: A cross-sectional study. J Clin Hypertens (Greenwich). 21:618–623. 2019.PubMed/NCBI View Article : Google Scholar

3 

Kintiraki E, Papakatsika S, Kotronis G, Goulis DG and Kotsis V: Pregnancy-induced hypertension. Hormones (Athens). 14:211–223. 2015.PubMed/NCBI View Article : Google Scholar

4 

Andrews L and Patel N: Correlation of serum lactate dehydrogenase and pregnancy induced hypertension with its adverse outcomes. Int J Res Med Sci. 4:1347–1350. 2016.

5 

Easterling TR: Pharmacological management of hypertension in pregnancy. Semin Perinatol. 38:487–495. 2014.PubMed/NCBI View Article : Google Scholar

6 

Chen C and Tao R: The impact of magnesium sulfate on pain control after laparoscopic cholecystectomy: A meta-analysis of randomized controlled studies. Surg Laparosc Endosc Percutan Tech. 28:349–353. 2018.PubMed/NCBI View Article : Google Scholar

7 

Lamarca B, Brewer J and Wallace K: IL-6-induced pathophysiology during pre-eclampsia: Potential therapeutic role for magnesium sulfate? Int J Interferon Cytokine Mediat Res. 2011:59–64. 2011.PubMed/NCBI View Article : Google Scholar

8 

Alexander JM, McIntire DD, Leveno KJ and Cunningham FG: Selective magnesium sulfate prophylaxis for the prevention of eclampsia in women with gestational hypertension. Obstet Gynecol. 108:826–832. 2006.PubMed/NCBI View Article : Google Scholar

9 

Sharma KJ, Greene N and Kilpatrick SJ: Oral labetalol compared to oral nifedipine for postpartum hypertension: A randomized controlled trial. Hypertens Pregnancy. 36:44–47. 2017.PubMed/NCBI View Article : Google Scholar

10 

Webster LM, Myers JE, Nelson-Piercy C, Harding K, Cruickshank JK, Watt-Coote I, Khalil A, Wiesender C, Seed PT and Chappell LC: Labetalol versus nifedipine as antihypertensive treatment for chronic hypertension in pregnancy: A randomized controlled trial. Hypertension. 70:915–922. 2017.PubMed/NCBI View Article : Google Scholar

11 

Martínez-Jiménez C, Cruz-Angeles J, Videa M and Martínez LM: Co-amorphous simvastatin-nifedipine with enhanced solubility for possible use in combination therapy of hypertension and hypercholesterolemia. Molecules. 23(2161)2018.PubMed/NCBI View Article : Google Scholar

12 

Wen J and Li X: Effect of magnesium sulfate combined with phentolamine and nifedipine for gestational hypertension and serum levels of LIF and apelin. J Coll Physicians Surg Pak. 29:231–234. 2019.PubMed/NCBI View Article : Google Scholar

13 

Sun Q, Xin F, Wen X, Lu C, Chen R and Ruan G: Protective effects of different kinds of filtered water on hypertensive mouse by suppressing oxidative stress and inflammation. Oxid Med Cell Longev. 2018(2917387)2018.PubMed/NCBI View Article : Google Scholar

14 

Niwa Y, Kanda H, Shikauchi Y, Saiura A, Matsubara K, Kitagawa T, Yamamoto J, Kubo T and Yoshikawa H: Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma. Oncogene. 24:6406–6417. 2005.PubMed/NCBI View Article : Google Scholar

15 

Wang Y, Lewis DF, Gu Y, Zhao S and Groome LJ: Elevated maternal soluble Gp130 and IL-6 levels and reduced Gp130 and SOCS-3 expressions in women complicated with preeclampsia. Hypertension. 57:336–342. 2011.PubMed/NCBI View Article : Google Scholar

16 

Yang GX, Sun Y, Tsuneyama K, Zhang W, Leung PS, He XS, Ansari AA, Bowlus C, Ridgway WM and Gershwin ME: Endogenous interleukin-22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice. Clin Exp Immunol. 185:154–164. 2016.PubMed/NCBI View Article : Google Scholar

17 

Cubro H, Kashyap S, Nath MC, Ackerman AW and Garovic VD: The role of interleukin-10 in the pathophysiology of preeclampsia. Curr Hypertens Rep. 20(36)2018.PubMed/NCBI View Article : Google Scholar

18 

Krishnan SM, Sobey CG, Latz E, Mansell A and Drummond GR: IL-1β and IL-18: Inflammatory markers or mediators of hypertension? Br J Pharmacol. 171:5589–5602. 2014.PubMed/NCBI View Article : Google Scholar

19 

Liu LS: Writing Group of 2010 Chinese Guidelines for the Management of Hypertension. 2010 Chinese guidelines for the management of hypertension. Zhonghua Xin Xue Guan Bing Za Zhi. 39:579–615. 2011.PubMed/NCBI(In Chinese).

20 

Świątkowska-Stodulska R, Kmieć P, Stefańska K and Sworczak K: Renin-Angiotensin-aldosterone system in the pathogenesis of pregnancy-induced hypertension. Exp Clin Endocrinol Diabetes. 126:362–366. 2018.PubMed/NCBI View Article : Google Scholar

21 

Cai G, Zhang B, Weng W, Yang L, Shi G, Xue S and Fu X: Associations of pregnancy-associated plasma protein-A level with essential hypertension and hypertensive disorders in pregnancy in Chinese population: A meta-analysis of 20 research studies involving 3332 individuals. BMJ Open. 5(e008210)2015.PubMed/NCBI View Article : Google Scholar

22 

Xu Q, Fan D, Li F and Zhang Z: Influence of serum HMW adiponectin level in patients with pregnancy-induced hypertension syndrome on the occurrence of eclampsia in secondary pregnancy. Exp Ther Med. 14:4972–4976. 2017.PubMed/NCBI View Article : Google Scholar

23 

Zhou Y, Chen ZH, Zhao XL, Qiao YH and Guo RX: Effect of serum high molecular weight adiponectin level on the occurrence of eclampsia during subsequent pregnancy in patients with primary pregnancy induced hypertension. Eur Rev Med Pharmacol Sci. 21:213–218. 2017.PubMed/NCBI

24 

Alves S, Churlaud G, Audrain M, Michaelsen-Preusse K, Fol R, Souchet B, Braudeau J, Korte M, Klatzmann D and Cartier N: Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice. Brain. 140:826–842. 2017.PubMed/NCBI View Article : Google Scholar

25 

Parulekar AD, Kao CC, Diamant Z and Hanania NA: Targeting the interleukin-4 and interleukin-13 pathways in severe asthma: Current knowledge and future needs. Curr Opin Pulm Med. 24:50–55. 2018.PubMed/NCBI View Article : Google Scholar

26 

Dinarello CA: Interleukin-1 mediated autoinflammation from heart disease to cancer. In: Textbook of Autoinflammation. Hashkes PJ, Laxer RM and Simon A (eds). Springer, Cham, pp711-725, 2019.

27 

Ridker PM, Libby P, MacFadyen JG, Thuren T, Ballantyne C, Fonseca F, Koenig W, Shimokawa H, Everett BM and Glynn RJ: Modulation of the interleukin-6 signalling pathway and incidence rates of atherosclerotic events and all-cause mortality: Analyses from the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS). Eur Heart J. 39:3499–3507. 2018.PubMed/NCBI View Article : Google Scholar

28 

Vijayan AL, Vanimaya Ravindran S, Saikant R, Lakshmi S, Kartik R and Manoj G: Procalcitonin: A promising diagnostic marker for sepsis and antibiotic therapy. J Intensive Care. 5(51)2017.PubMed/NCBI View Article : Google Scholar

29 

Magee LA, Miremadi S, Li J, Cheng C, Ensom MH, Carleton B, Côté AM and von Dadelszen P: Therapy with both magnesium sulfate and nifedipine does not increase the risk of serious magnesium-related maternal side effects in women with preeclampsia. Am J Obstet Gynecol. 193:153–163. 2005.PubMed/NCBI View Article : Google Scholar

30 

Chen Q, Zhao M, Guo F, Yin YX, Xiao JP, Stone PR and Chamley LW: The reduction of circulating levels of IL-6 in pregnant women with preeclampsia by magnesium sulphate and nifedipine: In vitro evidence for potential mechanisms. Placenta. 36:661–666. 2015.PubMed/NCBI View Article : Google Scholar

31 

Zhao S, Gu Y, Dong Q, Fan R and Wang Y: Altered interleukin-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with pre-eclampsia. Placenta. 29:1024–1028. 2008.PubMed/NCBI View Article : Google Scholar

32 

Wei T, Orfanidis K, Xu N, Janson P, Ståhle M, Pivarcsi A and Sonkoly E: The expression of microRNA-203 during human skin morphogenesis. Exp Dermatol. 19:854–856. 2010.PubMed/NCBI View Article : Google Scholar

33 

Wang Y, Dong Q, Gu Y and Groome LJ: Up-regulation of miR-203 expression induces endothelial inflammatory response: Potential role in preeclampsia. Am J Reprod Immunol. 76:482–490. 2016.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao F, Ai F, Wu J and Dong X: Changes and clinical significance of serum inflammatory factors in the treatment of pregnancy hypertension syndrome with magnesium sulfate combined with nifedipine. Exp Ther Med 20: 1796-1802, 2020.
APA
Zhao, F., Ai, F., Wu, J., & Dong, X. (2020). Changes and clinical significance of serum inflammatory factors in the treatment of pregnancy hypertension syndrome with magnesium sulfate combined with nifedipine. Experimental and Therapeutic Medicine, 20, 1796-1802. https://doi.org/10.3892/etm.2020.8863
MLA
Zhao, F., Ai, F., Wu, J., Dong, X."Changes and clinical significance of serum inflammatory factors in the treatment of pregnancy hypertension syndrome with magnesium sulfate combined with nifedipine". Experimental and Therapeutic Medicine 20.2 (2020): 1796-1802.
Chicago
Zhao, F., Ai, F., Wu, J., Dong, X."Changes and clinical significance of serum inflammatory factors in the treatment of pregnancy hypertension syndrome with magnesium sulfate combined with nifedipine". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1796-1802. https://doi.org/10.3892/etm.2020.8863
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao F, Ai F, Wu J and Dong X: Changes and clinical significance of serum inflammatory factors in the treatment of pregnancy hypertension syndrome with magnesium sulfate combined with nifedipine. Exp Ther Med 20: 1796-1802, 2020.
APA
Zhao, F., Ai, F., Wu, J., & Dong, X. (2020). Changes and clinical significance of serum inflammatory factors in the treatment of pregnancy hypertension syndrome with magnesium sulfate combined with nifedipine. Experimental and Therapeutic Medicine, 20, 1796-1802. https://doi.org/10.3892/etm.2020.8863
MLA
Zhao, F., Ai, F., Wu, J., Dong, X."Changes and clinical significance of serum inflammatory factors in the treatment of pregnancy hypertension syndrome with magnesium sulfate combined with nifedipine". Experimental and Therapeutic Medicine 20.2 (2020): 1796-1802.
Chicago
Zhao, F., Ai, F., Wu, J., Dong, X."Changes and clinical significance of serum inflammatory factors in the treatment of pregnancy hypertension syndrome with magnesium sulfate combined with nifedipine". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1796-1802. https://doi.org/10.3892/etm.2020.8863
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team