Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Added value of circulating miRNA expression profiling to sonographic TI‑RADS classification in the diagnosis of thyroid nodules

  • Authors:
    • Yu Mao
    • Fengjiao Zhang
    • Li He
    • Fang Luo
    • Lei Li
    • Yajie Huo
    • Zhiqiang Kang
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan 450007, P.R. China
    Copyright: © Mao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1589-1595
    |
    Published online on: June 10, 2020
       https://doi.org/10.3892/etm.2020.8870
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Potential use of sonographic TI‑RADS classification combined with circulating miRNA expression profiling in the diagnosis of thyroid nodules was explored. Retrospective analysis was performed on clinical data of 121 patients with thyroid nodules. The biopsy specimens of patients obtained through ultrasound‑guided aspiration and blood specimens were evaluated in Zhengzhou Central Hospital Affiliated to Zhengzhou University from June 2018 to June 2019. In addition, the blood specimen test results of 121 healthy volunteers (control group) who underwent physical examination were retrospectively analyzed. Results of sonographic TI‑RADS classification and circulating miRNA expression profiling were compared with the pathological results. Of the 212 nodules, 2 fell into TI‑RADS category 2 and were diagnosed as benign. Malignant nodules accounted for 4.35, 37.14, 84.78, 93.33 and 96.77% of those nodules that fell into TI‑RADS categories 3, 4a, 4b, 4c and 5, respectively. Of the 121 patients, 92.55% had with nodular goiter, 3.31% had inflammatory nodules, 2.48% toxic nodular goiter, 0.83% thyroid cysts and 0.83% thyroid tumors. A nodule that fell into a higher TI‑RADS classification category had a higher risk of malignancy. The expression levels of miRNA146b, miRNA187, miRNA375, miRNA‑222‑3p and miRNA‑151a‑5p were higher, while the level of miRNA138 was lower, in patients with either benign or malignant thyroid nodules compaed to those in the control group. The expression levels of miRNA146b, miRNA187, miRNA375, miRNA‑222‑3p and miRNA‑151a‑5p were higher, while the level of miRNA138 was lower, in patients with malignant thyroid nodules than those in patients with benign thyroid nodule (P<0.05). The AUC of the combined diagnostic method was 0.973, which was significantly different from the AUCs of the individual diagnostic method (P<0.05). In conclusion, sonographic TI‑RADS classification combined with circulating miRNA expression profiling can improve the diagnosis of thyroid nodules.
View Figures
View References

1 

Liu BX, Xie XY, Liang JY, Zheng YL, Huang GL, Zhou LY, Wang Z, Xu M and Lu MD: Shear wave elastography versus real-time elastography on evaluation thyroid nodules: A preliminary study. Eur J Radiol. 83:1135–1143. 2014.PubMed/NCBI View Article : Google Scholar

2 

Sun J, Cai J and Wang X: Real-time ultrasound elastography for differentiation of benign and malignant thyroid nodules: A meta-analysis. J Ultrasound Med. 33:495–502. 2014.PubMed/NCBI View Article : Google Scholar

3 

Chen KY, Chen CN, Wu MH, Ho MC, Tai HC, Kuo WH, Huang WC, Wang YH, Chen A and Chang KJ: Computerized quantification of ultrasonic heterogeneity in thyroid nodules. Ultrasound Med Biol. 40:2581–2589. 2014.PubMed/NCBI View Article : Google Scholar

4 

Hoang JK, Middleton WD, Farjat AE, Langer JE, Reading CC, Teefey SA, Abinanti N, Boschini FJ, Bronner AJ, Dahiya N, et al: Reduction in thyroid nodule biopsies and improved accuracy with American College of Radiology Thyroid Imaging Reporting and Data System. Radiology. 287:185–193. 2018.PubMed/NCBI View Article : Google Scholar

5 

Coskun E, Neumann M, Schlee C, Liebertz F, Heesch S, Goekbuget N, Hoelzer D and Baldus CD: MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia. Leukemia. 37:647–656. 2013.PubMed/NCBI View Article : Google Scholar

6 

Kwak JY, Han KH, Yoon JH, Moon HJ, Son EJ, Park SH, Jung HK, Choi JS, Kim BM and Kim EK: Thyroid imaging reporting and data system for US features of nodules: a step in establishing better stratification of cancer risk. Radiology. 260:892–899. 2011.PubMed/NCBI View Article : Google Scholar

7 

Çakal E, Şahin M, Ünsal İÖ, Güngüneş A, Akkaymak E, Özkaya EÇ, Bozkurt NÇ, Özbek M and Delibaşı T: Elastography in the differential diagnosis of thyroid nodules. Ultrason Imaging. 37:251–257. 2015.PubMed/NCBI View Article : Google Scholar

8 

Zhang XL and Qian LX: Ultrasonic features of papillary thyroid microcarcinoma and non-microcarcinoma. Exp Ther Med. 8:1335–1339. 2014.PubMed/NCBI View Article : Google Scholar

9 

Zhu M, Yi M, Kim CH, Deng C, Li Y, Medina D, Stephens RM and Green JE: Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage. Genome Biol. 12(R77)2011.PubMed/NCBI View Article : Google Scholar

10 

Lerebours F, Cizeron-Clairac G, Susini A, Vacher S, Mouret-Fourme E, Belichard C, Brain E, Alberini JL, Spyratos F, Lidereau R, et al: miRNA expression profiling of inflammatory breast cancer identifies a 5-miRNA signature predictive of breast tumor aggressiveness. Int J Cancer. 133:1614–1623. 2013.PubMed/NCBI View Article : Google Scholar

11 

Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, et al: Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA. 105:10513–10518. 2008.PubMed/NCBI View Article : Google Scholar

12 

Riazi A, Kalantarhormozi M, Nabipour I, Eghbali SS, Farzaneh M, Javadi H, Ostovar A, Seyedabadi M and Assadi M: Technetium-99m methoxyisobutyl isonitrile scintigraphy in the assessment of cold thyroid nodules: Is it time to change the approach to the management of cold thyroid nodules? Nucl Med Commun. 35:51–57. 2014.PubMed/NCBI View Article : Google Scholar

13 

Dogan S, Atmaca A, Dagdelen S, Erbas B and Erbas T: Evaluation of thyroid diseases and differentiated thyroid cancer in acromegalic patients. Endocrine. 45:114–121. 2014.PubMed/NCBI View Article : Google Scholar

14 

Basha MAA, Alnaggar AA, Refaat R, El-Maghraby AM, Refaat MM, Abd Elhamed ME, Abdalla AAEM, Aly SA, Hanafy AS, Mohamed AEM, et al: The validity and reproducibility of the thyroid imaging reporting and data system (TI-RADS) in categorization of thyroid nodules: Multicentre prospective study. Eur J Radiol. 117:184–192. 2019.PubMed/NCBI View Article : Google Scholar

15 

Labourier E, Shifrin A, Busseniers AE, Lupo MA, Manganelli ML, Andruss B, Wylie D and Beaudenon-Huibregtse S: Molecular testing for miRNA, mRNA, and DNA on fine-needle aspiration improves the preoperative diagnosis of thyroid nodules with indeterminate cytology. J Clin Endocrinol Metab. 100:2743–2750. 2015.PubMed/NCBI View Article : Google Scholar

16 

Rossing M, Kaczkowski B, Futoma-Kazmierczak E, Glud M, Klausen M, Faber J, Nygaard B, Kiss K, Sørensen CH, Nielsen FC, et al: A simple procedure for routine RNA extraction and miRNA array analyses from a single thyroid in vivo fine needle aspirate. Scand J Clin Lab Invest. 70:529–534. 2010.PubMed/NCBI View Article : Google Scholar

17 

Ratert N, Meyer HA, Jung M, Lioudmer P, Mollenkopf HJ, Wagner I, Miller K, Kilic E, Erbersdobler A, Weikert S, et al: miRNA profiling identifies candidate miRNAs for bladder cancer diagnosis and clinical outcome. J Mol Diagn. 15:695–705. 2013.PubMed/NCBI View Article : Google Scholar

18 

Ma Y, Liu M, Tan T, Yan A, Guo L, Jiang K, Tan C and Wan Y: Deep eutectic solvents used as extraction solvent for the determination of flavonoids from Camellia oleifera flowers by high-performance liquid chromatography. Phytochem Anal. 29:639–648. 2018.PubMed/NCBI View Article : Google Scholar

19 

Zhou SY, Wang R, Deng LQ, Zhang XL and Chen M: A new isoflavanone from Ficus tikoua Bur. Nat Prod Res. 32:2516–2522. 2018.PubMed/NCBI View Article : Google Scholar

20 

Croce CM: Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet. 10:704–714. 2009.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Mao Y, Zhang F, He L, Luo F, Li L, Huo Y and Kang Z: Added value of circulating miRNA expression profiling to sonographic TI‑RADS classification in the diagnosis of thyroid nodules. Exp Ther Med 20: 1589-1595, 2020.
APA
Mao, Y., Zhang, F., He, L., Luo, F., Li, L., Huo, Y., & Kang, Z. (2020). Added value of circulating miRNA expression profiling to sonographic TI‑RADS classification in the diagnosis of thyroid nodules. Experimental and Therapeutic Medicine, 20, 1589-1595. https://doi.org/10.3892/etm.2020.8870
MLA
Mao, Y., Zhang, F., He, L., Luo, F., Li, L., Huo, Y., Kang, Z."Added value of circulating miRNA expression profiling to sonographic TI‑RADS classification in the diagnosis of thyroid nodules". Experimental and Therapeutic Medicine 20.2 (2020): 1589-1595.
Chicago
Mao, Y., Zhang, F., He, L., Luo, F., Li, L., Huo, Y., Kang, Z."Added value of circulating miRNA expression profiling to sonographic TI‑RADS classification in the diagnosis of thyroid nodules". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1589-1595. https://doi.org/10.3892/etm.2020.8870
Copy and paste a formatted citation
x
Spandidos Publications style
Mao Y, Zhang F, He L, Luo F, Li L, Huo Y and Kang Z: Added value of circulating miRNA expression profiling to sonographic TI‑RADS classification in the diagnosis of thyroid nodules. Exp Ther Med 20: 1589-1595, 2020.
APA
Mao, Y., Zhang, F., He, L., Luo, F., Li, L., Huo, Y., & Kang, Z. (2020). Added value of circulating miRNA expression profiling to sonographic TI‑RADS classification in the diagnosis of thyroid nodules. Experimental and Therapeutic Medicine, 20, 1589-1595. https://doi.org/10.3892/etm.2020.8870
MLA
Mao, Y., Zhang, F., He, L., Luo, F., Li, L., Huo, Y., Kang, Z."Added value of circulating miRNA expression profiling to sonographic TI‑RADS classification in the diagnosis of thyroid nodules". Experimental and Therapeutic Medicine 20.2 (2020): 1589-1595.
Chicago
Mao, Y., Zhang, F., He, L., Luo, F., Li, L., Huo, Y., Kang, Z."Added value of circulating miRNA expression profiling to sonographic TI‑RADS classification in the diagnosis of thyroid nodules". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1589-1595. https://doi.org/10.3892/etm.2020.8870
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team