Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2020 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effects of rivastigmine hydrogen tartrate and donepezil hydrochloride on the cognitive function and mental behavior of patients with Alzheimer's disease

  • Authors:
    • Xiaohong Zhang
    • Ronghua Yu
    • Huilin Wang
    • Ruifeng Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Rehabilitation, Luoyang Central Hospital, Luoyang, Henan 471000, P.R. China, Department of Neurology, Luoyang Central Hospital, Luoyang, Henan 471000, P.R. China
  • Pages: 1789-1795
    |
    Published online on: June 10, 2020
       https://doi.org/10.3892/etm.2020.8872
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to examine the effects of rivastigmine hydrogen tartrate and donepezil hydrochloride on the cognitive function and mental behavior of patients with Alzheimer's disease (AD). For this purpose, a total of 126 patients with AD admitted to Luoyang Central Hospital from January, 2018 to December, 2018 were enrolled. Patients were divided into different groups according to the treatment they selected. Patients treated with single‑agent donepezil were separated into a monotherapy group (n=56), and patients receiving donepezil plus rivastigmine were placed in the combination group (n=70). Before and after treatment, the cognitive functions, mental behavior and quality of life of the patients in the two groups were respectively evaluated by the Alzheimer's Disease Assessment Scale‑Cognitive Subscale (ADAS‑Cog), the Mini‑Mental State Examination (MMSE), the Blessed‑Roth Dementia Scale (BRDS) and the QOL‑AD. In addition, the serum bradykinin level was detected by enzyme‑linked immunosorbent assay. Following treatment, the MMSE score, BRDS, ADAS‑Cog and QOL‑AD scores were improved compared with those before treatment (P<0.05). However, following treatment, the 4 scores in the combination group were significantly higher than those in the monotherapy group (P<0.05). No significant differences were observed in the incidence of adverse reactions between the 2 groups (P>0.05). Following treatment, the bradykinin level in both groups was significantly decreased (P<0.05), although the decrease in the combination group was more significant than that in the monotherapy group (P<0.05). On the whole, the findings of the present study indicate that rivastigmine hydrogen tartrate used in combination with donepezil hydrochloride relieves the symptoms and improves the quality of life of patients with AD more effectively, which may be related to the reduction of the bradykinin level in these patients.
View Figures

Figure 1

View References

1 

Anand R, Gill KD and Mahdi AA: Therapeutics of Alzheimer's disease: Past, present and future. Neuropharmacology. 76:27–50. 2014.PubMed/NCBI View Article : Google Scholar

2 

Alzheimer's Association: 2018 Alzheimer's disease facts and figures. Alzheimer Dement 14: 367-429, 2018.

3 

Lombardo S and Maskos U: Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment. Neuropharmacology. 96:255–262. 2015.PubMed/NCBI View Article : Google Scholar

4 

Birks JS, Chong LY and Grimley Evans J: Rivastigmine for Alzheimer's disease. Cochrane Database Syst Rev. 9(CD001191)2015.(Epub ahead of print). PubMed/NCBI View Article : Google Scholar

5 

Islam MM, Gurung AB, Bhattacharjee A, Aguan K and Mitra S: Human serum albumin reduces the potency of acetylcholinesterase inhibitor based drugs for Alzheimer's disease. Chem Biol Interact. 249:1–9. 2016.PubMed/NCBI View Article : Google Scholar

6 

Tsoi KK, Chan JY, Leung NW, Hirai HW, Wong SY and Kwok TC: Combination therapy showed limited superiority over monotherapy for Alzheimer disease: A meta-analysis of 14 randomized trials. J Am Med Dir Assoc. 17:863.e1–e8. 2016.PubMed/NCBI View Article : Google Scholar

7 

D'onofrio G, Sancarlo D, Addante F, Ciccone F, Cascavilla L, Paris F, Elia AC, Nuzzaci C, Picoco M, Greco A, et al: A pilot randomized controlled trial evaluating an integrated treatment of rivastigmine transdermal patch and cognitive stimulation in patients with Alzheimer's disease. Int J Geriatr Psychiatry. 30:965–975. 2015.PubMed/NCBI View Article : Google Scholar

8 

Han HJ, Kwon JC, Kim JE, Kim SG, Park JM, Park KW, Park KC, Park KH, Moon SY, Seo SW, et al: Effect of rivastigmine or memantine add-on therapy is affected by butyrylcholinesterase genotype in patients with probable Alzheimer's disease. Eur Neurol. 73:23–28. 2015.PubMed/NCBI View Article : Google Scholar

9 

Birks JS and Grimley Evans J: Rivastigmine for Alzheimer's disease. Cochrane Database Syst Rev. 2015(CD001191)2015.PubMed/NCBI View Article : Google Scholar

10 

Maher-Edwards G, Dixon R, Hunter J, Gold M, Hopton G, Jacobs G, Hunter J and Williams P: SB-742457 and donepezil in Alzheimer disease: A randomized, placebo-controlled study. Int J Geriatr Psychiatry. 26:536–544. 2011.PubMed/NCBI View Article : Google Scholar

11 

Nokkari A, Abou-El-Hassan H, Mechref Y, Mondello S, Kindy MS, Jaffa AA and Kobeissy F: Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms. Prog Neurobiol. 165-167:26–50. 2018.PubMed/NCBI View Article : Google Scholar

12 

Zhao WQ and Alkon DL: Alzheimer's disease diagnosis based on mitogen-activated protein kinase phosphorylation. U.S. Pat Appl. 9:188–595. 2015.PubMed/NCBI View Article : Google Scholar

13 

Ni R, Kindler DR, Waag R, Rouault M, Ravikumar P, Nitsch R, Rudin M, Camici GG, Liberale L, Kulic L and Klohs J: fMRI reveals mitigation of cerebrovascular dysfunction by bradykinin receptors 1 and 2 inhibitor noscapine in a mouse model of cerebral amyloidosis. Front Aging Neurosci. 11(27)2019.PubMed/NCBI View Article : Google Scholar

14 

Makitani K, Nakagawa S, Izumi Y, Akaike A and Kume T: Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes. J Pharmacol Sci. 134:37–44. 2017.PubMed/NCBI View Article : Google Scholar

15 

McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, et al: The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 7:263–269. 2011.PubMed/NCBI View Article : Google Scholar

16 

Arevalo-Rodriguez I, Smailagic N, Roqué I Figuls M, Ciapponi A, Sanchez-Perez E, Giannakou A, Pedraza OL, Bonfill Cosp X and Cullum S: Mini-mental state examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev. 2015(CD010783)2015.PubMed/NCBI View Article : Google Scholar

17 

Blessed G, Tomlinson BE and Roth M: Blessed-Roth dementia scale (DS). Psychopharmacol Bull. 24:705–708. 1988.PubMed/NCBI

18 

Podhorna J, Krahnke T, Shear M and Harrison JE: Alzheimer's Disease Neuroimaging Initiative: Alzheimer's disease assessment scale-cognitive subscale variants in mild cognitive impairment and mild Alzheimer's disease: Change over time and the effect of enrichment strategies. Alzheimers Res Ther. 8(8)2016.PubMed/NCBI View Article : Google Scholar

19 

Logsdon RG, Gibbons LE, McCurry SM and Teri L: Quality of life in Alzheimer's disease: Patient and caregiver reports. J Ment health Aging. 5:21–32. 1999.

20 

Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, Cedazo-Minguez A, Dubois B, Edvardsson D, Feldman H, et al: Defeating Alzheimer's disease and other dementias: A priority for European science and society. Lancet Neurol. 15:455–532. 2016.PubMed/NCBI View Article : Google Scholar

21 

Cummings J, Aisen PS, DuBois B, Frölich L, Jack CR Jr, Jones RW, Morris JC, Raskin J, Dowsett SA and Scheltens P: Drug development in Alzheimer's disease: The path to 2025. Alzheimers Res Ther. 8(39)2016.PubMed/NCBI View Article : Google Scholar

22 

Shao ZQ: Comparison of the efficacy of four cholinesterase inhibitors in combination with memantine for the treatment of Alzheimer's disease. Int J Clin Exp Med. 8:2944–2948. 2015.PubMed/NCBI

23 

Godyń J, Jończyk J, Panek D and Malawska B: Therapeutic strategies for Alzheimer's disease in clinical trials. Pharmacol Rep. 68:127–138. 2016.PubMed/NCBI View Article : Google Scholar

24 

Chase TN, Farlow MR and Clarence-Smith K: Donepezil plus Solifenacin (CPC-201) treatment for Alzheimer's disease. Neurotherapeutics. 14:405–416. 2017.PubMed/NCBI View Article : Google Scholar

25 

Kearney MC, Caffarel-Salvador E, Fallows SJ, McCarthy HO and Donnelly RF: Microneedle-mediated delivery of donepezil: Potential for improved treatment options in Alzheimer's disease. Eur J Pharm Biopharm. 103:43–50. 2016.PubMed/NCBI View Article : Google Scholar

26 

Mohamed LA, Keller JN and Kaddoumi A: Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model. Biochim Biophys Acta. 1862:778–787. 2016.PubMed/NCBI View Article : Google Scholar

27 

Oh YS, Kim JS and Lee PH: Effect of rivastigmine on behavioral and psychiatric symptoms of Parkinson's disease dementia. J Mov Disord. 8:98–102. 2015.PubMed/NCBI View Article : Google Scholar

28 

Cummings J, Lai TJ, Hemrungrojn S, Mohandas E, Yun Kim S, Nair G and Dash A: Role of donepezil in the management of neuropsychiatric symptoms in Alzheimer's disease and dementia with Lewy bodies. CNS Neurosci Ther. 22:159–166. 2016.PubMed/NCBI View Article : Google Scholar

29 

Nieto RA, Deardorff WJ and Grossberg GT: Efficacy of rivastigmine tartrate, transdermal system, in Alzheimer's disease. Expert Opin Pharmacother. 17:861–870. 2016.PubMed/NCBI View Article : Google Scholar

30 

Montero-Odasso M, Muir-Hunter SW, Oteng-Amoako A, Gopaul K, Islam A, Borrie M, Wells J and Speechley M: Donepezil improves gait performance in older adults with mild Alzheimer's disease: A phase II clinical trial. J Alzheimers Dis. 43:193–199. 2015.PubMed/NCBI View Article : Google Scholar

31 

Bitencourt RM, Guerra de Souza AC, Bicca MA, Pamplona FA, de Mello N, Passos GF, Medeiros R, Takahashi RN, Calixto JB and Prediger RD: Blockade of hippocampal bradykinin B1 receptors improves spatial learning and memory deficits in middle-aged rats. Behav Brain Res. 316:74–81. 2017.PubMed/NCBI View Article : Google Scholar

32 

Asraf K, Torika N, Danon A and Fleisher-Berkovich S: Involvement of the bradykinin B1 receptor in microglial activation: In vitro and in vivo studies. Front Endocrinol (Lausanne). 8(82)2017.PubMed/NCBI View Article : Google Scholar

33 

Bicca MA, Costa R, Loch-Neckel G, Figueiredo CP, Medeiros R and Calixto JB: B2 receptor blockage prevents Aβ-induced cognitive impairment by neuroinflammation inhibition. Behav Brain Res. 278:482–491. 2015.PubMed/NCBI View Article : Google Scholar

34 

Ashby EL, Love S and Kehoe PG: Assessment of activation of the plasma kallikrein-kinin system in frontal and temporal cortex in Alzheimer's disease and vascular dementia. Neurobiol Aging. 33:1345–1355. 2012.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Yu R, Wang H and Zheng R: Effects of rivastigmine hydrogen tartrate and donepezil hydrochloride on the cognitive function and mental behavior of patients with Alzheimer's disease. Exp Ther Med 20: 1789-1795, 2020.
APA
Zhang, X., Yu, R., Wang, H., & Zheng, R. (2020). Effects of rivastigmine hydrogen tartrate and donepezil hydrochloride on the cognitive function and mental behavior of patients with Alzheimer's disease. Experimental and Therapeutic Medicine, 20, 1789-1795. https://doi.org/10.3892/etm.2020.8872
MLA
Zhang, X., Yu, R., Wang, H., Zheng, R."Effects of rivastigmine hydrogen tartrate and donepezil hydrochloride on the cognitive function and mental behavior of patients with Alzheimer's disease". Experimental and Therapeutic Medicine 20.2 (2020): 1789-1795.
Chicago
Zhang, X., Yu, R., Wang, H., Zheng, R."Effects of rivastigmine hydrogen tartrate and donepezil hydrochloride on the cognitive function and mental behavior of patients with Alzheimer's disease". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1789-1795. https://doi.org/10.3892/etm.2020.8872
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Yu R, Wang H and Zheng R: Effects of rivastigmine hydrogen tartrate and donepezil hydrochloride on the cognitive function and mental behavior of patients with Alzheimer's disease. Exp Ther Med 20: 1789-1795, 2020.
APA
Zhang, X., Yu, R., Wang, H., & Zheng, R. (2020). Effects of rivastigmine hydrogen tartrate and donepezil hydrochloride on the cognitive function and mental behavior of patients with Alzheimer's disease. Experimental and Therapeutic Medicine, 20, 1789-1795. https://doi.org/10.3892/etm.2020.8872
MLA
Zhang, X., Yu, R., Wang, H., Zheng, R."Effects of rivastigmine hydrogen tartrate and donepezil hydrochloride on the cognitive function and mental behavior of patients with Alzheimer's disease". Experimental and Therapeutic Medicine 20.2 (2020): 1789-1795.
Chicago
Zhang, X., Yu, R., Wang, H., Zheng, R."Effects of rivastigmine hydrogen tartrate and donepezil hydrochloride on the cognitive function and mental behavior of patients with Alzheimer's disease". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1789-1795. https://doi.org/10.3892/etm.2020.8872
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team