Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Stomach ‘tastes’ the food and adjusts its emptying: A neurophysiological hypothesis (Review)

  • Authors:
    • Toma Papacocea
    • Raluca Papacocea
    • Mugurel Rădoi
    • Silviu Pițuru
    • Daniela Gabriela Balan
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, ‘St. Pantelimon’ Emergency Hospital, 021659 Bucharest, Romania, Department of Physiology I, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Neurosurgery, National Institute of Neurology and Neurovascular Diseases, 041914 Bucharest, Romania, Department of Dental Medicine II, ‘Carol Davila’ University of Medicine and Pharmacy, 010221 Bucharest, Romania, Department of Physiology III, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
  • Pages: 2392-2395
    |
    Published online on: June 11, 2020
       https://doi.org/10.3892/etm.2020.8874
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The presence of taste receptors and their secondary messengers in stomach raised the possibility that the stomach might play a role in food ‘tasting’ and consequently, it might initiate specific adaptations of its secretory and motor function. Furthermore, activated taste receptors release a variety of chemical mediators able to modulate the activity of the enteric nervous system (ENS), and also to influence both secretory and motor functions of the stomach. Based on the physiological fundamental structure of a reflex arch, the stimulation of the gastric taste receptors activates sensory neurons of the gastric wall, continues with motor neurons which initiate the contraction of the local smooth muscle fibers. Beyond this, compounds which act on different taste receptors initiate different responses, stimulatory or inhibitory. These interactions may be translated in the gastric ability to selectively evacuate different nutritive compounds into the duodenum. Consequently, sugars could be favored to the detriment of other compounds.
View Figures
View References

1 

Watson H: Biological membranes. Essays Biochem. 59:43–69. 2015.PubMed/NCBI View Article : Google Scholar

2 

Archer E: Progress in cardiovascular diseases in defense of sugar: A critique of diet-centrism. Prog Cardiovasc Dis. 61:10–19. 2018.PubMed/NCBI View Article : Google Scholar

3 

Jayasinghe SN, Kruger R, Walsh DCI, Cao G, Rivers S, Richter M and Breier BH: Is sweet taste perception associated with sweet food liking and intake? Nutrients. 9:1–19. 2017.PubMed/NCBI View Article : Google Scholar

4 

Ferreira JG, Tellez LA, Ren X, Yeckel CW and de Araujo IE: Regulation of fat intake in the absence of flavour signalling. J Physiol. 590:953–972. 2012.PubMed/NCBI View Article : Google Scholar

5 

Nicklaus S: The role of food experiences during early childhood in food pleasure learning. Appetite. 104:3–9. 2016.PubMed/NCBI View Article : Google Scholar

6 

de Jong J, Vanderschuren L and Adan R: The mesolimbic system and eating addiction: What sugar does and does not do. Curr Opin Behav Sci. 9:118–125. 2016.

7 

San Gabriel AM: Taste receptors in the gastrointestinal system. Flavour (Lond). 4(14)2015.

8 

Yoshida R, Niki M, Jyotaki M, Sanematsu K, Shigemura N and Ninomiya Y: Modulation of sweet responses of taste receptor cells. Semin Cell Dev Biol. 24:226–231. 2013.PubMed/NCBI View Article : Google Scholar

9 

Pang G, Xie J, Chen Q and Hu Z: How functional foods play critical roles in human health. Food Sci Hum Wellness. 1:26–60. 2012.

10 

Tsujimoto T: Effects of tastes and taste receptors. Int J Cardiol. 260(195)2018.PubMed/NCBI View Article : Google Scholar

11 

Iatridi V, Hayes JE and Yeomans MR: Reconsidering the classification of sweet taste liker phenotypes: A methodological review. Food Qual Prefer. 72:56–76. 2019.

12 

Saltiel MY, Kuhre R, Christiansen C, Eliasen R, Conde-Frieboes K, Rosenkilde M and Holst J: Sweet taste receptor activation in the gut is of and GIP secretion. Nutrients. 9(418)2017.PubMed/NCBI View Article : Google Scholar

13 

Rozengurt N, Wu SV, Chen MC, Huang C, Sternini C and Rozengurt E: Colocalization of the α-subunit of gustducin with PYY and GLP-1 in L cells of human colon. Am J Physiol Gastrointest Liver Physiol. 291:G792–G802. 2006.PubMed/NCBI View Article : Google Scholar

14 

Hass N, Schwarzenbacher K and Breer H: A cluster of gustducin-expressing cells in the mouse stomach associated with two distinct populations of enteroendocrine cells. Histochem Cell Biol. 128:457–471. 2007.PubMed/NCBI View Article : Google Scholar

15 

Freund JR and Lee RJ: Taste receptors in the upper airway. World J Otorhinolaryngol Head Neck Surg. 4:67–76. 2018.PubMed/NCBI View Article : Google Scholar

16 

Gilca M and Dragos D: Extraoral taste receptor discovery: New light on ayurvedic pharmacology. Evid Based Complement Alternat Med. 2017(5435831)2017.PubMed/NCBI View Article : Google Scholar

17 

An SS and Liggett SB: Taste and smell GPCRs in the lung: Evidence for a previously unrecognized widespread chemosensory system. Cell Signal. 41:82–88. 2018.PubMed/NCBI View Article : Google Scholar

18 

Li F: Taste perception: From the tongue to the testis. Mol Hum Reprod. 19:349–360. 2013.PubMed/NCBI View Article : Google Scholar

19 

Höfer D, Püschel B and Drenckhahn D: Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin. Proc Natl Acad Sci USA. 93:6631–6634. 1996.PubMed/NCBI View Article : Google Scholar

20 

Trivedi BP: Neuroscience: Hardwired for taste. Nature. 486:S7–S9. 2012.PubMed/NCBI View Article : Google Scholar

21 

Yu R, Li Z, Liu S, Huwatibieke B, Li Y, Yin Y and Zhang W: Activation of mTORC1 signaling in gastric X/A-like cells induces spontaneous pancreatic fibrosis and derangement of glucose metabolism by reducing ghrelin production. EBioMedicine. 36:304–315. 2018.PubMed/NCBI View Article : Google Scholar

22 

Kokrashvili Z, Mosinger B and Margolskee RF: Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones. Am J Clin Nutr. 90:822S–825S. 2009.PubMed/NCBI View Article : Google Scholar

23 

Roper SD and Chaudhari N: Taste buds: Cells, signals and synapses. Nat Rev Neurosci. 18:485–497. 2017.PubMed/NCBI View Article : Google Scholar

24 

Di Pizio A, Ben Shoshan-Galeczki Y, Hayes JE and Niv MY: Bitter and sweet tasting molecules: It's complicated. Neurosci Lett. 700:56–63. 2019.PubMed/NCBI View Article : Google Scholar

25 

Ekstrand B, Young JF and Rasmussen MK: Taste receptors in the gut - A new target for health promoting properties in diet. Food Res Int. 100:1–8. 2017.PubMed/NCBI View Article : Google Scholar

26 

Welcome MO, Mastorakis NE and Pereverzev VA: Sweet taste receptor signaling network: Possible implication for cognitive functioning. Neurol Res Int. 2015(606479)2015.PubMed/NCBI View Article : Google Scholar

27 

Roper SD: Taste buds as peripheral chemosensory processors. Semin Cell Dev Biol. 24:71–79. 2013.PubMed/NCBI View Article : Google Scholar

28 

Holmes GM, Browning KN, Tong M, Qualls-Creekmore E and Travagli RA: Vagally mediated effects of glucagon-like peptide s1: In vitro and in vivo gastric actions. J Physiol. 587:4749–4759. 2009.PubMed/NCBI View Article : Google Scholar

29 

Donnelly D: The structure and function of the glucagon-like peptide-1 receptor and its ligands. Br J Pharmacol. 166:27–41. 2012.PubMed/NCBI View Article : Google Scholar

30 

Gejl M, Lerche S, Egefjord L, Brock B, Møller N, Vang K, Rodell AB, Bibby BM, Holst JJ, Rungby J, et al: Glucagon-like peptide-1 (GLP-1) raises blood-brain glucose transfer capacity and hexokinase activity in human brain. Front Neuroenergetics. 5(2)2013.PubMed/NCBI View Article : Google Scholar

31 

Lu Z, Yeung CK, Lin G, Yew DTW, Andrews PLR and Rudd JA: Centrally located GLP-1 receptors modulate gastric slow waves and cardiovascular function in ferrets consistent with the induction of nausea. Neuropeptides. 65:28–36. 2017.PubMed/NCBI View Article : Google Scholar

32 

Bornstein JC: Purinergic mechanisms in the control of gastrointestinal motility. Purinergic Signal. 4:197–212. 2008.PubMed/NCBI View Article : Google Scholar

33 

Wideman TH, Zautra AJ and Edwards RR: Re-thinking the fear avoidance model: Toward a multi-dimensional framework of pain-related disability. NIH Public Access. 154:2262–2265. 2014.

34 

Norris AW and Uc A: A novel stomach-pancreas connection: More than physical. EBioMedicine. 37:25–26. 2018.PubMed/NCBI View Article : Google Scholar

35 

Spencer NJ, Hibberd TJ, Travis L, Wiklendt L, Costa M, Hu H, Brookes SJ, Wattchow DA, Dinning PG, Keating DJ, et al: Identification of a rhythmic firing pattern in the enteric nervous system that generates rhythmic electrical activity in smooth muscle. J Neurosci. 38:5507–5522. 2018.PubMed/NCBI View Article : Google Scholar

36 

Marathe CS, Rayner CK, Jones KL and Horowitz M: Effects of GLP-1 and incretin-based therapies on gastrointestinal motor function. Exp Diabetes Res. 2011(279530)2011.PubMed/NCBI View Article : Google Scholar

37 

Waluga M, Jonderko K, Domosławska E, Matwiejszyn A, Dzielicki M, Krusiec-Świdergoł B and Kasicka-Jonderko A: Effects of taste stimulation on gastric myoelectrical activity and autonomic balance. Saudi J Gastroenterol. 24:100–108. 2018.PubMed/NCBI View Article : Google Scholar

38 

Goyal RK, Guo Y and Mashimo H: Advances in the physiology of gastric emptying. Neurogastroenterol Motil. 31(e13546)2019.PubMed/NCBI View Article : Google Scholar

39 

Pal A, Brasseur JG and Abrahamsson B: A stomach road or ‘Magenstrasse’ for gastric emptying. J Biomech. 40:1202–1210. 2007.PubMed/NCBI View Article : Google Scholar

40 

Nakatani Y, Maeda M, Matsumura M, Shimizu R, Banba N, Aso Y, Yasu T and Harasawa H: Effect of GLP-1 receptor agonist on gastrointestinal tract motility and residue rates as evaluated by capsule endoscopy. Diabetes Metab. 43:430–437. 2017.PubMed/NCBI View Article : Google Scholar

41 

Young RL: Sensing via intestinal sweet taste pathways. Front Neurosci. 5(23)2011.PubMed/NCBI View Article : Google Scholar

42 

Van Den Abeele J, Rubbens J, Brouwers J and Augustijns P: The dynamic gastric environment and its impact on drug and formulation behaviour. Eur J Pharm Sci. 96:207–231. 2017.PubMed/NCBI View Article : Google Scholar

43 

Soares A, Beraldi EJ, Ferreira PEB, Bazotte RB and Buttow NC: Intestinal and neuronal myenteric adaptations in the small intestine induced by a high-fat diet in mice. BMC Gastroenterol. 15(3)2015.PubMed/NCBI View Article : Google Scholar

44 

Janssen S and Depoortere I: Nutrient sensing in the gut: New roads to therapeutics? Trends Endocrinol Metab. 24:92–100. 2013.PubMed/NCBI View Article : Google Scholar

45 

Danielsen EM and van Deurs B: Galectin-4 and small intestinal brush border enzymes form clusters. Mol Biol Cell. 8:2241–2251. 1997.PubMed/NCBI View Article : Google Scholar

46 

Marciani L, Cox EF, Pritchard SE, Major G, Hoad CL, Mellows M, Hussein MO, Costigan C, Fox M, Gowland PA, et al: Additive effects of gastric volumes and macronutrient composition on the sensation of postprandial fullness in humans. Eur J Clin Nutr. 69:380–384. 2015.PubMed/NCBI View Article : Google Scholar

47 

Schemann M, Rohn M and Michel K: Motor control of the stomach. Eur Rev Med Pharmacol Sci. 12 (Suppl 1):41–51. 2008.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Papacocea T, Papacocea R, Rădoi M, Pițuru S and Balan DG: Stomach ‘tastes’ the food and adjusts its emptying: A neurophysiological hypothesis (Review). Exp Ther Med 20: 2392-2395, 2020.
APA
Papacocea, T., Papacocea, R., Rădoi, M., Pițuru, S., & Balan, D.G. (2020). Stomach ‘tastes’ the food and adjusts its emptying: A neurophysiological hypothesis (Review). Experimental and Therapeutic Medicine, 20, 2392-2395. https://doi.org/10.3892/etm.2020.8874
MLA
Papacocea, T., Papacocea, R., Rădoi, M., Pițuru, S., Balan, D. G."Stomach ‘tastes’ the food and adjusts its emptying: A neurophysiological hypothesis (Review)". Experimental and Therapeutic Medicine 20.3 (2020): 2392-2395.
Chicago
Papacocea, T., Papacocea, R., Rădoi, M., Pițuru, S., Balan, D. G."Stomach ‘tastes’ the food and adjusts its emptying: A neurophysiological hypothesis (Review)". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2392-2395. https://doi.org/10.3892/etm.2020.8874
Copy and paste a formatted citation
x
Spandidos Publications style
Papacocea T, Papacocea R, Rădoi M, Pițuru S and Balan DG: Stomach ‘tastes’ the food and adjusts its emptying: A neurophysiological hypothesis (Review). Exp Ther Med 20: 2392-2395, 2020.
APA
Papacocea, T., Papacocea, R., Rădoi, M., Pițuru, S., & Balan, D.G. (2020). Stomach ‘tastes’ the food and adjusts its emptying: A neurophysiological hypothesis (Review). Experimental and Therapeutic Medicine, 20, 2392-2395. https://doi.org/10.3892/etm.2020.8874
MLA
Papacocea, T., Papacocea, R., Rădoi, M., Pițuru, S., Balan, D. G."Stomach ‘tastes’ the food and adjusts its emptying: A neurophysiological hypothesis (Review)". Experimental and Therapeutic Medicine 20.3 (2020): 2392-2395.
Chicago
Papacocea, T., Papacocea, R., Rădoi, M., Pițuru, S., Balan, D. G."Stomach ‘tastes’ the food and adjusts its emptying: A neurophysiological hypothesis (Review)". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2392-2395. https://doi.org/10.3892/etm.2020.8874
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team