Open Access

Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells

  • Authors:
    • Yuyan Qi
    • Zhaoxia Ding
    • Yushuang Yao
    • Feifei Ren
    • Min  Yin
    • Songbin Yang
    • Aiping Chen
  • View Affiliations

  • Published online on: June 11, 2020     https://doi.org/10.3892/etm.2020.8880
  • Pages: 1329-1336
  • Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ovarian cancer (OC) is one of the prominent causes of mortality in female patients diagnosed with gynecologic malignancies. While it has previously been demonstrated that apigenin inhibits cell growth in colon and breast cancer cells, the effect of apigenin in OC cells is not fully understood. Therefore, the aim of the present study was to investigate the impact of apigenin on cell death and resistance to cisplatin in OC cells. It was found that apigenin inhibited proliferation, hindered cell cycle progression and promoted SKOV3 cell apoptosis. Moreover, these effects were also observed in cisplatin‑resistant SKOV3/DDP cells. Furthermore, apigenin reduced the mitochondrial transmembrane potential, and elevated the ratios of cleaved caspase‑3/caspase‑3 and Bax/Bcl‑2 in the two cell types. Reverse transcription‑quantitative PCR and western blotting results demonstrated that apigenin significantly downregulated Mcl‑1 at the transcriptional and translational levels in SKOV3 and SKOV3/DDP cells, which was responsible for its cytotoxic functions and chemosensitizing effects. Collectively, the present results identified the impact of apigenin on OC cell death and resistance to cisplatin, and the potential molecular mechanisms. However, additional studies are required to further elucidate the underlying mechanisms.

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August-2020
Volume 20 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Qi, Y., Ding, Z., Yao, Y., Ren, F., Yin, M., Yang, S., & Chen, A. (2020). Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells. Experimental and Therapeutic Medicine, 20, 1329-1336. https://doi.org/10.3892/etm.2020.8880
MLA
Qi, Y., Ding, Z., Yao, Y., Ren, F., Yin, M., Yang, S., Chen, A."Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells". Experimental and Therapeutic Medicine 20.2 (2020): 1329-1336.
Chicago
Qi, Y., Ding, Z., Yao, Y., Ren, F., Yin, M., Yang, S., Chen, A."Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1329-1336. https://doi.org/10.3892/etm.2020.8880