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Article Open Access

Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells

Retraction in: /10.3892/etm.2025.12941
  • Authors:
    • Yuyan Qi
    • Zhaoxia Ding
    • Yushuang Yao
    • Feifei Ren
    • Min  Yin
    • Songbin Yang
    • Aiping Chen
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China, Department of Obstetrics and Gynecology, The Affiliated Hospital of Taishan Medical University, Taian, Shandong 271000, P.R. China
    Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1329-1336
    |
    Published online on: June 11, 2020
       https://doi.org/10.3892/etm.2020.8880
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Abstract

Ovarian cancer (OC) is one of the prominent causes of mortality in female patients diagnosed with gynecologic malignancies. While it has previously been demonstrated that apigenin inhibits cell growth in colon and breast cancer cells, the effect of apigenin in OC cells is not fully understood. Therefore, the aim of the present study was to investigate the impact of apigenin on cell death and resistance to cisplatin in OC cells. It was found that apigenin inhibited proliferation, hindered cell cycle progression and promoted SKOV3 cell apoptosis. Moreover, these effects were also observed in cisplatin‑resistant SKOV3/DDP cells. Furthermore, apigenin reduced the mitochondrial transmembrane potential, and elevated the ratios of cleaved caspase‑3/caspase‑3 and Bax/Bcl‑2 in the two cell types. Reverse transcription‑quantitative PCR and western blotting results demonstrated that apigenin significantly downregulated Mcl‑1 at the transcriptional and translational levels in SKOV3 and SKOV3/DDP cells, which was responsible for its cytotoxic functions and chemosensitizing effects. Collectively, the present results identified the impact of apigenin on OC cell death and resistance to cisplatin, and the potential molecular mechanisms. However, additional studies are required to further elucidate the underlying mechanisms.
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1 

Enroth S, Berggrund M, Lycke M, Lundberg M, Assarsson E, Olovsson M, Stålberg K, Sundfeldt K and Gyllensten U: A two-step strategy for identification of plasma protein biomarkers for endometrial and ovarian cancer. Clin Proteomics. 15(38)2018.PubMed/NCBI View Article : Google Scholar

2 

Zhou L, Xu X, Liu H, Hu X, Zhang W, Ye M and Zhu X: Prognosis analysis of histone deacetylases mRNA expression in ovarian cancer patients. J Cancer. 9:4547–4555. 2018.PubMed/NCBI View Article : Google Scholar

3 

Park SJ, Kim J, Kim SN, Lee EJ, Oh S, Seol A, Lee N, Chang SJ and Kim HS: Practice patterns of surgery for advanced ovarian cancer: Analysis from international surveys. Jpn J Clin Oncol. 49:137–145. 2018.PubMed/NCBI View Article : Google Scholar

4 

Yousefi H, Momeny M, Ghaffari SH, Parsanejad N, Poursheikhani A, Javadikooshesh S, Zarrinrad G, Esmaeili F, Alishahi Z, Sabourinejad Z, et al: IL 6/IL 6R pathway is a therapeutic target in chemoresistant ovarian cancer. Tumori. 105:84–91. 2019.PubMed/NCBI View Article : Google Scholar

5 

Momeny M, Eyvani H, Barghi F, Ghaffari SH, Javadikooshesh S, Hassanvand Jamadi R, Esmaeili F, Alishahi Z, Zaghal A, Bashash D, et al: Inhibition of bromodomain and extraterminal domain reduces growth and invasive characteristics of chemoresistant ovarian carcinoma cells. Anticancer Drugs. 29:1011–1020. 2018.PubMed/NCBI View Article : Google Scholar

6 

Ahmed N, Escalona R, Leung D, Chan E and Kannourakis G: Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells. Semin Cancer Biol. 53:265–281. 2018.PubMed/NCBI View Article : Google Scholar

7 

Ozbey U, Attar R, Romero MA, Alhewairini SS, Afshar B, Sabitaliyevich UY, Hanna-Wakim L, Ozcelik B and Farooqi AA: Apigenin as an effective anticancer natural product: Spotlight on TRAIL, WNT/β-catenin, JAK-STAT pathways, and microRNAs. J Cell Biochem. (Oct 2)2018.PubMed/NCBI View Article : Google Scholar : (Epub ahead of print).

8 

Perez-Moral N, Saha S, Philo M, Hart DJ, Winterbone MS, Hollands WJ, Spurr M, Bows J, van der Velpen V, Kroon PA, et al: Comparative bio-accessibility, bioavailability and bioequivalence of quercetin, apigenin, glucoraphanin and carotenoids from freeze-dried vegetables incorporated into a baked snack versus minimally processed vegetables: Evidence from in vitro models and a human bioavailability study. J Funct Foods. 48:410–419. 2018. View Article : Google Scholar

9 

Wang Y, Xu Z, Huang Y, Wen X, Wu Y, Zhao Y and Ni Y: Extraction, purification, and hydrolysis behavior of apigenin-7-O-glucoside from chrysanthemum morifolium tea. Molecules. 23(23)2018.PubMed/NCBI View Article : Google Scholar

10 

Hong J, Fristiohady A, Nguyen CH, Milovanovic D, Huttary N, Krieger S, Hong J, Geleff S, Birner P, Jäger W, et al: Apigenin and luteolin attenuate the breaching of MDA-MB231 breast cancer spheroids through the lymph endothelial barrier in vitro. Front Pharmacol. 9(220)2018.PubMed/NCBI View Article : Google Scholar

11 

Maeda Y, Takahashi H, Nakai N, Yanagita T, Ando N, Okubo T, Saito K, Shiga K, Hirokawa T, Hara M, et al: Apigenin induces apoptosis by suppressing Bcl-xl and Mcl-1 simultaneously via signal transducer and activator of transcription 3 signaling in colon cancer. Int J Oncol. 52:1661–1673. 2018.PubMed/NCBI View Article : Google Scholar

12 

Vrhovac Madunić I, Madunić J, Antunović M, Paraždik M, Garaj-Vrhovac V, Breljak D, Marijanović I and Gajski G: Apigenin, a dietary flavonoid, induces apoptosis, DNA damage, and oxidative stress in human breast cancer MCF-7 and MDA MB-231 cells. Naunyn Schmiedebergs Arch Pharmacol. 391:537–550. 2018.PubMed/NCBI View Article : Google Scholar

13 

Sun Q, Lu NN and Feng L: Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. Biochem Biophys Res Commun. 498:164–170. 2018.PubMed/NCBI View Article : Google Scholar

14 

Xia Y, Yuan M, Li S, Thuan UT, Nguyen TT, Kang TW, Liao W, Lian S and Jung YD: Apigenin suppresses the IL-1β-induced expression of the urokinase-type plasminogen activator receptor by inhibiting MAPK-mediated AP-1 and NF-κB signaling in human bladder cancer T24 Cells. J Agric Food Chem. 66:7663–7673. 2018.PubMed/NCBI View Article : Google Scholar

15 

Souza RP, Bonfim-Mendonça PS, Gimenes F, Ratti BA, Kaplum V, Bruschi ML, Nakamura CV, Silva SO, Maria-Engler SS and Consolaro ME: Oxidative stress triggered by apigenin induces apoptosis in a comprehensive panel of human cervical cancer-derived cell lines. Oxid Med Cell Longev. 2017(1512745)2017.PubMed/NCBI View Article : Google Scholar

16 

Zhou Z, Tang M, Liu Y, Zhang Z, Lu R and Lu J: Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line. Anticancer Drugs. 28:446–456. 2017.PubMed/NCBI View Article : Google Scholar

17 

Shao H, Jing K, Mahmoud E, Huang H, Fang X and Yu C: Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263. Mol Cancer Ther. 12:2640–2650. 2013.PubMed/NCBI View Article : Google Scholar

18 

Shukla S, Kanwal R, Shankar E, Datt M, Chance MR, Fu P, MacLennan GT and Gupta S: Apigenin blocks IKKα activation and suppresses prostate cancer progression. Oncotarget. 6:31216–31232. 2015.PubMed/NCBI View Article : Google Scholar

19 

Yan X, Qi M, Li P, Zhan Y and Shao H: Apigenin in cancer therapy: Anti-cancer effects and mechanisms of action. Cell Biosci. 7(50)2017.PubMed/NCBI View Article : Google Scholar

20 

Verma AK, Laha B, Pandey M, Pal U and Ghosh M: Cholesterol-lowering drug, in combination with chromium chloride, induces early apoptotic signals in intracellular L. donovani amastigotes, leading to death. J Biosci. 42:427–438. 2017.PubMed/NCBI View Article : Google Scholar

21 

Ganta KK, Mandal A and Chaubey B: Depolarization of mitochondrial membrane potential is the initial event in non-nucleoside reverse transcriptase inhibitor efavirenz induced cytotoxicity. Cell Biol Toxicol. 33:69–82. 2017. View Article : Google Scholar

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real time quantitative PCR and the 2(Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

23 

Wang J, Song C, Cao X, Li H, Cai H and Ma Y, Huang Y, Lan X, Lei C and Ma Y: miR 208b regulates cell cycle and promotes skeletal muscle cell proliferation by targeting CDKN1A. J Cell Physiol. 234:3720–3729. 2019.PubMed/NCBI View Article : Google Scholar

24 

Zhong Y, Jin C, Gan J, Wang X, Shi Z, Xia X and Peng X: Apigenin attenuates patulin induced apoptosis in HEK293 cells by modulating ROS mediated mitochondrial dysfunction and caspase signal pathway. Toxicon. 137:106–113. 2017.PubMed/NCBI View Article : Google Scholar

25 

Xiang W, Yang CY and Bai L: MCL 1 inhibition in cancer treatment. OncoTargets Ther. 11:7301–7314. 2018.PubMed/NCBI View Article : Google Scholar

26 

Singel KL, Grzankowski KS, Khan A, Grimm MJ, D'Auria AC, Morrell K, Eng KH, Hylander B, Mayor PC, Emmons TR, et al: Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer. Br J Cancer. 2018.PubMed/NCBI View Article : Google Scholar

27 

Liu N, Sheng X, Liu Y, Zhang X and Yu J: Increased CD70 expression is associated with clinical resistance to cisplatin-based chemotherapy and poor survival in advanced ovarian carcinomas. OncoTargets Ther. 6:615–619. 2013.PubMed/NCBI View Article : Google Scholar

28 

Pieterse Z, Amaya-Padilla MA, Singomat T, Binju M, Madjid BD, Yu Y and Kaur P: Ovarian cancer stem cells and their role in drug resistance. Int J Biochem Cell Biol. 106:117–126. 2019.PubMed/NCBI View Article : Google Scholar

29 

Pal MK, Jaiswar SP, Dwivedi A, Goyal S, Dwivedi VN, Pathak AK, Kumar V, Sankhwar PL and Ray RS: Synergistic effect of graphene oxide coated nanotised apigenin with paclitaxel (GO-NA/PTX): A ROS dependent mitochondrial mediated apoptosis in ovarian cancer. Anticancer Agents Med Chem. 17:1721–1732. 2017.PubMed/NCBI View Article : Google Scholar

30 

Balusamy SR, Perumalsamy H, Huq MA and Balasubramanian B: Anti-proliferative activity of Origanum vulgare inhibited lipogenesis and induced mitochondrial mediated apoptosis in human stomach cancer cell lines. Biomed Pharmacother. 108:1835–1844. 2018. View Article : Google Scholar

31 

Shah D, Das P, Alam MA, Mahajan N, Romero F, Shahid M, Singh H and Bhandari V: MicroRNA 34a promotes endothelial dysfunction and mitochondrial mediated apoptosis in murine models of acute lung injury. Am J Respir Cell Mol Biol. 60:465–477. 2019.PubMed/NCBI View Article : Google Scholar

32 

Dirks AJ and Leeuwenburgh C: Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12. Free Radic Biol Med. 36:27–39. 2004.PubMed/NCBI View Article : Google Scholar

33 

Cummings BS and Schnellmann RG: Cisplatin-induced renal cell apoptosis: Caspase 3-dependent and -independent pathways. J Pharmacol Exp Ther. 302:8–17. 2002.PubMed/NCBI View Article : Google Scholar

34 

Xie Q, Su J, Jiao B, Shen L, Ma L, Qu X, Yu C, Jiang X, Xu Y and Sun L: ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells. Int J Oncol. 49:2507–2519. 2016.PubMed/NCBI View Article : Google Scholar

35 

Xu Y, Gao W, Zhang Y, Wu S, Liu Y, Deng X, Xie L, Yang J, Yu H, Su J, et al: ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells. Int J Oncol. 53:1055–1068. 2018.PubMed/NCBI View Article : Google Scholar

36 

Cardenas C, Montagna MK, Pitruzzello M, Lima E, Mor G and Alvero AB: Adipocyte microenvironment promotes Bclxl expression and confers chemoresistance in ovarian cancer cells. Apoptosis. 22:558–569. 2017.PubMed/NCBI View Article : Google Scholar

37 

Habata S, Iwasaki M, Sugio A, Suzuki M, Tamate M, Satohisa S, Tanaka R and Saito T: BAG3-mediated Mcl-1 stabilization contributes to drug resistance via interaction with USP9X in ovarian cancer. Int J Oncol. 49:402–410. 2016.PubMed/NCBI View Article : Google Scholar

38 

Matsuura K, Huang NJ, Cocce K, Zhang L and Kornbluth S: Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin. Oncogene. 36:1698–1706. 2017.PubMed/NCBI View Article : Google Scholar

39 

Dai Y, Jin S, Li X and Wang D: The involvement of Bcl-2 family proteins in AKT-regulated cell survival in cisplatin resistant epithelial ovarian cancer. Oncotarget. 8:1354–1368. 2017.PubMed/NCBI View Article : Google Scholar

40 

O' Reilly E, Dhami SPS, Baev DV, Ortutay C, Halpin-McCormick A, Morrell R, Santocanale C, Samali A, Quinn J, O'Dwyer ME, et al: Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML. Sci Rep. 8(15752)2018.PubMed/NCBI View Article : Google Scholar

41 

Tyson-Capper A and Gautrey H: Regulation of Mcl-1 alternative splicing by hnRNP F, H1 and K in breast cancer cells. RNA Biol. 15:1448–1457. 2018.PubMed/NCBI View Article : Google Scholar

42 

Sugio A, Iwasaki M, Habata S, Mariya T, Suzuki M, Osogami H, Tamate M, Tanaka R and Saito T: BAG3 upregulates Mcl-1 through downregulation of miR-29b to induce anticancer drug resistance in ovarian cancer. Gynecol Oncol. 134:615–623. 2014.PubMed/NCBI View Article : Google Scholar

43 

Gao X, Wang B, Wei X, Men K, Zheng F, Zhou Y, Zheng Y, Gou M, Huang M, Guo G, et al: Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer. Nanoscale. 4:7021–7030. 2012.PubMed/NCBI View Article : Google Scholar

44 

Goncharenko-Khaider N, Matte I, Lane D, Rancourt C and Piché A: Ovarian cancer ascites increase Mcl-1 expression in tumor cells through ERK1/2-Elk-1 signaling to attenuate TRAIL-induced apoptosis. Mol Cancer. 11(84)2012.PubMed/NCBI View Article : Google Scholar

45 

Yuan Z, Cao K, Lin C, Li L, Liu HY, Zhao XY, Liu L, Deng HX, Li J, Nie CL, et al: The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1. Mol Med. 17:1262–1274. 2011.PubMed/NCBI View Article : Google Scholar

46 

Shan S, Shi J, Yang P, Jia B, Wu H, Zhang X and Li Z: Apigenin restrains colon cancer cell proliferation via targeted blocking of pyruvate kinase M2 dependent glycolysis. J Agric Food Chem. 65:8136–8144. 2017.PubMed/NCBI View Article : Google Scholar

47 

Perrott KM, Wiley CD, Desprez PY and Campisi J: Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. Geroscience. 39:161–173. 2017.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Qi Y, Ding Z, Yao Y, Ren F, Yin M, Yang S and Chen A: Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells Retraction in /10.3892/etm.2025.12941. Exp Ther Med 20: 1329-1336, 2020.
APA
Qi, Y., Ding, Z., Yao, Y., Ren, F., Yin, M., Yang, S., & Chen, A. (2020). Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells Retraction in /10.3892/etm.2025.12941. Experimental and Therapeutic Medicine, 20, 1329-1336. https://doi.org/10.3892/etm.2020.8880
MLA
Qi, Y., Ding, Z., Yao, Y., Ren, F., Yin, M., Yang, S., Chen, A."Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells Retraction in /10.3892/etm.2025.12941". Experimental and Therapeutic Medicine 20.2 (2020): 1329-1336.
Chicago
Qi, Y., Ding, Z., Yao, Y., Ren, F., Yin, M., Yang, S., Chen, A."Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells Retraction in /10.3892/etm.2025.12941". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1329-1336. https://doi.org/10.3892/etm.2020.8880
Copy and paste a formatted citation
x
Spandidos Publications style
Qi Y, Ding Z, Yao Y, Ren F, Yin M, Yang S and Chen A: Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells Retraction in /10.3892/etm.2025.12941. Exp Ther Med 20: 1329-1336, 2020.
APA
Qi, Y., Ding, Z., Yao, Y., Ren, F., Yin, M., Yang, S., & Chen, A. (2020). Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells Retraction in /10.3892/etm.2025.12941. Experimental and Therapeutic Medicine, 20, 1329-1336. https://doi.org/10.3892/etm.2020.8880
MLA
Qi, Y., Ding, Z., Yao, Y., Ren, F., Yin, M., Yang, S., Chen, A."Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells Retraction in /10.3892/etm.2025.12941". Experimental and Therapeutic Medicine 20.2 (2020): 1329-1336.
Chicago
Qi, Y., Ding, Z., Yao, Y., Ren, F., Yin, M., Yang, S., Chen, A."Apigenin induces apoptosis and counteracts cisplatin‑induced chemoresistance via Mcl‑1 in ovarian cancer cells Retraction in /10.3892/etm.2025.12941". Experimental and Therapeutic Medicine 20, no. 2 (2020): 1329-1336. https://doi.org/10.3892/etm.2020.8880
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