Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effect of GM6001 on the expression of syndecan‑1 in rats with acute kidney injury and its protective effect on the kidneys

  • Authors:
    • Kunying Zhang
    • Rongxin Li
    • Guodong Xu
    • Huirong Han
    • Lili Qin
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China, Department of Pharmacy, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China, Department of Pathology, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China, Department of Anesthesiology, Weifang Medical University, Weifang, Shandong 261042, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2049-2054
    |
    Published online on: June 17, 2020
       https://doi.org/10.3892/etm.2020.8892
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Expression of syndecan‑1 (SDC‑1) in rats with acute kidney injury and the protective effect of GM6001 on the kidney were investigated. Fifty SD rats were selected and randomly divided into control group (CG) (n=15), treatment control group (TCG) (n=10), module group (MG) (n=15) and treatment group (TG) (n=10). In TG, the model of acute renal injury (AKI) in rats was established after pretreatment of intraperitoneal injection of GM6001 one day before modeling. In MG, the same amount of saline was injected intraperitoneally one day before modeling and the same treatment was done on the day of modeling. In CG, the same amount of saline was injected intraperitoneally one day before modeling but the model was not made. In TCG, rats were pretreated with intraperitoneal injection of GM6001 one day before modeling but the model was not made. The contents of blood urea nitrogen (BUN) in serum, serum creatinine (SCR), uric acid (UA) and blood β2‑microglobulin (β2‑MG) were detected by ELISA. The content of SDC‑1 in renal tissues was detected by qRT‑PCR and western blotting. Expression of SDC‑1 in renal tissue of 24 rats after modeling was lower than that of MG (P<0.050). SDC‑1 expression was the highest in TG (P<0.05). Compared with before modeling, the contents of BUN, SCR, UA and β2‑MG in MG and TG increased (P<0.05). After modeling, the contents of serum BUN, SCR, UA and β2‑MG in TG were significantly lower than those in MG (P<0.05). The levels of SDC‑1 in renal tissue of rats with acute kidney injury increased. After GM6001 treatment, SDC‑1 levels can be improved and has a certain protective effect on the kidneys.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Bellomo R, Kellum JA and Ronco C: Acute kidney injury. Lancet. 380:756–766. 2012.PubMed/NCBI View Article : Google Scholar

2 

Vijayan A, Faubel S, Askenazi DJ, Cerda J, Fissell WH, Heung M, Humphreys BD, Koyner JL, Liu KD, Mour G, et al: American Society of Nephrology Acute Kidney Injury Advisory Group: Clinical use of the urine biomarker [TIMP-2]x[IGFBP7] for acute kidney injury risk assessment. Am J Kidney Dis. 68:19–28. 2016.PubMed/NCBI View Article : Google Scholar

3 

Szeto CC, Li PK, Johnson DW, Bernardini J, Dong J, Figueiredo AE, Ito Y, Kazancioglu R, Moraes T, Van Esch S, et al: ISPD catheter-related infection recommendations: 2017 update. Perit Dial Int. 37:141–154. 2017.PubMed/NCBI View Article : Google Scholar

4 

Doi K and Rabb H: Impact of acute kidney injury on distant organ function: Recent findings and potential therapeutic targets. Kidney Int. 89:555–564. 2016.PubMed/NCBI View Article : Google Scholar

5 

Mennerich D, Vogel A, Klaman I, Dahl E, Lichtner RB, Rosenthal A, Pohlenz HD, Thierauch KH and Sommer A: Shift of syndecan-1 expression from epithelial to stromal cells during progression of solid tumours. Eur J Cancer. 40:1373–1382. 2004.PubMed/NCBI View Article : Google Scholar

6 

Lu Z, Song N, Shen B, Xu X, Fang Y, Shi Y, Ning Y, Hu J, Dai Y, Ding X, et al: Syndecan-1 shedding inhibition to protect against ischemic acute kidney injury through HGF target signaling pathway. Transplantation. 102:e331–e344. 2018.PubMed/NCBI View Article : Google Scholar

7 

Junior GS, Sobral D, Cavalcante MG, Meneses G, Martins A and Daher E: Novel biomarkers of kidney injury and endothelial dysfunction among HIV patients. Int J Infect Dis. 73(252)2018.

8 

Gill SE, Nadler ST, Li Q, Frevert CW, Park PW, Chen P and Parks WC: Shedding of syndecan-1/CXCL1 complexes by matrix metalloproteinase 7 functions as an epithelial checkpoint of neutrophil activation. Am J Respir Cell Mol Biol. 55:243–251. 2016.PubMed/NCBI View Article : Google Scholar

9 

Wang X, Zuo D, Chen Y, Li W, Liu R, He Y, Ren L, Zhou L, Deng T, Wang X, et al: Shed Syndecan-1 is involved in chemotherapy resistance via the EGFR pathway in colorectal cancer. Br J Cancer. 111:1965–1976. 2014.PubMed/NCBI View Article : Google Scholar

10 

Li F, Majd H, Weir MD, Arola DD and Xu HH: Inhibition of matrix metalloproteinase activity in human dentin via novel antibacterial monomer. Dent Mater. 31:284–292. 2015.PubMed/NCBI View Article : Google Scholar

11 

Makris K and Spanou L: Acute kidney injury: Definition, pathophysiology and clinical phenotypes. Clin Biochem Rev. 37:85–98. 2016.PubMed/NCBI

12 

Brauer R, Ge L, Schlesinger SY, Birkland TP, Huang Y, Parimon T, Lee V, McKinney BL, McGuire JK, Parks WC, et al: Syndecan-1 attenuates lung injury during influenza infection by potentiating c-met signaling to suppress epithelial apoptosis. Am J Respir Crit Care Med. 194:333–344. 2016.PubMed/NCBI View Article : Google Scholar

13 

Gandley RE, Althouse A, Jeyabalan A, Bregand-White JM, McGonigal S, Myerski AC, Gallaher M, Powers RW and Hubel CA: Low soluble syndecan-1 precedes preeclampsia. PLoS One. 11(e0157608)2016.PubMed/NCBI View Article : Google Scholar

14 

Götte M, Kersting C, Ruggiero M, Tio J, Tulusan AH, Kiesel L and Wülfing P: Predictive value of syndecan-1 expression for the response to neoadjuvant chemotherapy of primary breast cancer. Anticancer Res. 26B:621–627. 2006.PubMed/NCBI

15 

Jing Z, Wei-Jie Y, Yi-Feng ZG and Jing H: Downregulation of Syndecan-1 induce glomerular endothelial cell dysfunction through modulating internalization of VEGFR-2. Cell Signal. 28:826–837. 2016.PubMed/NCBI View Article : Google Scholar

16 

Schmidt M, Mansfield KE, Bhaskaran K, Nitsch D, Sørensen HT, Smeeth L and Tomlinson LA: Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study. BMJ356. (j791)2017.PubMed/NCBI View Article : Google Scholar

17 

Zhang Z, Zhao J, Dong W, Remer E, Li J, Demirjian S, Zabell J and Campbell SC: Acute kidney injury after partial nephrectomy: Role of parenchymal mass reduction and ischemia and impact on subsequent functional recovery. Eur Urol. 69:745–752. 2016.PubMed/NCBI View Article : Google Scholar

18 

Tsuji T, Ohishi K, Takeda A, Goto D, Sato T, Ohashi N, Fujigaki Y, Kato A and Yasuda H: The impact of serum uric acid reduction on renal function and blood pressure in chronic kidney disease patients with hyperuricemia. Clin Exp Nephrol. 22:1300–1308. 2018.PubMed/NCBI View Article : Google Scholar

19 

Wong J, Sridharan S, Berdeprado J, Vilar E, Viljoen A, Wellsted D and Farrington K: Predicting residual kidney function in hemodialysis patients using serum β-trace protein and β2-microglobulin. Kidney Int. 89:1090–1098. 2016.PubMed/NCBI View Article : Google Scholar

20 

de Melo Bezerra Cavalcante CT, Castelo Branco KM, Pinto Júnior VC, Meneses GC, de Oliveira Neves FM, de Souza NM, Penaforte KL, Martins AM and Libório AB: Syndecan-1 improves severe acute kidney injury prediction after pediatric cardiac surgery. J Thorac Cardiovasc Surg. 152:178–186.e2. 2016.PubMed/NCBI View Article : Google Scholar

21 

Mosaad NA, Lotfy HM, Farag YM, Mahfouz RH and Shahin RM: Study of serum syndecan-1 levels in a group of Egyptian juvenile systemic lupus erythematosus patients. Immunol Lett. 181:16–19. 2017.PubMed/NCBI View Article : Google Scholar

22 

Kato M, Wang H, Kainulainen V, Fitzgerald ML, Ledbetter S, Ornitz DM and Bernfield M: Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2. Nat Med. 4:691–697. 1998.PubMed/NCBI View Article : Google Scholar

23 

Xiong C, Zang X, Zhou X, Liu L, Masucci MV, Tang J, Li X, Liu N, Bayliss G, Zhao TC, et al: Pharmacological inhibition of Src kinase protects against acute kidney injury in a murine model of renal ischemia/reperfusion. Oncotarget. 8:31238–31253. 2017.PubMed/NCBI View Article : Google Scholar

24 

Zeng Y, Yao X, Chen L, Yan Z, Liu J, Zhang Y, Feng T, Wu J and Liu X: Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop. Oncotarget. 7:63324–63337. 2016.PubMed/NCBI View Article : Google Scholar

25 

Dolmatov IY, Shulga AP, Ginanova TT, Eliseikina MG and Lamash NE: Metalloproteinase inhibitor GM6001 delays regeneration in holothurians. Tissue Cell. 59:1–9. 2019.PubMed/NCBI View Article : Google Scholar

26 

Liu X and Han Q: Efficacy of GM6001 as an adjuvant to ceftriaxone in a neonatal rat model of Streptococcus pneumoniae meningitis. Acta Neurobiol Exp (Wars). 74:489–496. 2014.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang K, Li R, Xu G, Han H and Qin L: Effect of GM6001 on the expression of syndecan‑1 in rats with acute kidney injury and its protective effect on the kidneys. Exp Ther Med 20: 2049-2054, 2020.
APA
Zhang, K., Li, R., Xu, G., Han, H., & Qin, L. (2020). Effect of GM6001 on the expression of syndecan‑1 in rats with acute kidney injury and its protective effect on the kidneys. Experimental and Therapeutic Medicine, 20, 2049-2054. https://doi.org/10.3892/etm.2020.8892
MLA
Zhang, K., Li, R., Xu, G., Han, H., Qin, L."Effect of GM6001 on the expression of syndecan‑1 in rats with acute kidney injury and its protective effect on the kidneys". Experimental and Therapeutic Medicine 20.3 (2020): 2049-2054.
Chicago
Zhang, K., Li, R., Xu, G., Han, H., Qin, L."Effect of GM6001 on the expression of syndecan‑1 in rats with acute kidney injury and its protective effect on the kidneys". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2049-2054. https://doi.org/10.3892/etm.2020.8892
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang K, Li R, Xu G, Han H and Qin L: Effect of GM6001 on the expression of syndecan‑1 in rats with acute kidney injury and its protective effect on the kidneys. Exp Ther Med 20: 2049-2054, 2020.
APA
Zhang, K., Li, R., Xu, G., Han, H., & Qin, L. (2020). Effect of GM6001 on the expression of syndecan‑1 in rats with acute kidney injury and its protective effect on the kidneys. Experimental and Therapeutic Medicine, 20, 2049-2054. https://doi.org/10.3892/etm.2020.8892
MLA
Zhang, K., Li, R., Xu, G., Han, H., Qin, L."Effect of GM6001 on the expression of syndecan‑1 in rats with acute kidney injury and its protective effect on the kidneys". Experimental and Therapeutic Medicine 20.3 (2020): 2049-2054.
Chicago
Zhang, K., Li, R., Xu, G., Han, H., Qin, L."Effect of GM6001 on the expression of syndecan‑1 in rats with acute kidney injury and its protective effect on the kidneys". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2049-2054. https://doi.org/10.3892/etm.2020.8892
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team