Severe DRESS syndrome after carbamazepine intake in a case with multiple addictions: A case report

Vrinceanu,Daniela; Dumitru,Mihai; Stefan,Adrian; Neagos,Adriana; Musat,Gabriela; Nica,Elena   Adriana

doi:10.3892/etm.2020.8894

September-2020 Volume 20 Issue 3

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September-2020 Volume 20 Issue 3

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Case Report

Severe DRESS syndrome after carbamazepine intake in a case with multiple addictions: A case report

Authors:
- Daniela Vrinceanu
- Mihai Dumitru
- Adrian Stefan
- Adriana Neagos
- Gabriela Musat
- Elena Adriana Nica
View Affiliations / Copyright

Affiliations: ENT Department, Bucharest Emergency University Hospital, 010271 Bucharest, Romania, Department of Anatomy, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, ENT Department, Târgu Mureș University of Medicine and Pharmacy, 540139 Târgu Mureș, Romania, ENT Department, ‘Sânta Maria’ Clinical Hospital, 011172 Bucharest, Romania, Department of Anesthesia and ICU, Bucharest Emergency University Hospital, 020021 Bucharest, Romania
Pages: 2377-2380
|
Published online on: June 17, 2020

https://doi.org/10.3892/etm.2020.8894
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Abstract

A case is presented of a male with drug rash with eosinophilia and systemic symptoms (DRESS) syndrome induced by carbamazepine intake. The patient presented all the elements of DRESS syndrome: Skin reaction, fever, enlargement of the lymph nodes, increased eosinophils and lymphocytes, with associated organ dysfunctions. The patient was admitted with acute laryngeal edema and imminence of respiratory insufficiency. The escalation of symptoms for this syndrome is typical, even after the administering of the the culprit medicine has ceased. However, in this case, the most difficult aspect was the complex treatment scheme prior to admission. All medical compounds involved in the background treatment were substituted with other substances in order to control the immune response. Current knowledge regarding DRESS is reviewed and possible influence of various etiologies over the present case are discussed. Clinicians should be aware of this rare situation with life-threatening potential. We benefited from the advantage of reuniting the knowledge of a complex team of experts from various tertiary emergency units in Romania.

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1	Cho YT, Yang CW and Chu CY: Drug reaction with eosinophilia and systemic symptoms (DRESS): An interplay among drugs, viruses, and immune system. Int J Mol Sci. 18:1243–1264. 2017.PubMed/NCBI View Article : Google Scholar
2	Wu X, Yang F, Chen S, Xiong H, Zhu Q, Gao X, Xing Q and Luo X: Clinical, viral and genetic characteristics of drug reaction with eosinophilia and systemic symptoms (DRESS) in Shanghai, China. Acta Derm Venereol. 98:401–405. 2018.PubMed/NCBI View Article : Google Scholar
3	El Omairi N, Abourazzak S, Chaouki S, Atmani S and Hida M: Drug reaction with eosinophilia and systemic symptom (DRESS) induced by carbamazepine: A case report and literature review. Pan Afr Med J. 18(9)2014.PubMed/NCBI View Article : Google Scholar
4	Hiransuthikul A, Rattananupong T, Klaewsongkram J, Rerknimitr P, Pongprutthipan M and Ruxrungtham K: Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS): 11 years retrospective study in Thailand. Allergol Int. 65:432–438. 2016.PubMed/NCBI View Article : Google Scholar
5	Musette P and Janela B: New insights into drug reaction with eosinophilia and systemic symptoms pathophysiology. Front Med (Lausanne). 4(179)2017.PubMed/NCBI View Article : Google Scholar
6	Oliveira AM, Carvalho R, Martins A and Reis J: Acute hepatitis in the DRESS syndrome. GE Port J Gastroenterol. 23:304–308. 2016.PubMed/NCBI View Article : Google Scholar
7	Wang L and Li LF: Difficult clinical management of antituberculosis DRESS syndrome complicated by MRSA infection: A case report. Medicine (Baltimore). 96(e6346)2017.PubMed/NCBI View Article : Google Scholar
8	Munch M, Peuvrel L, Brocard A, Saint Jean M, Khammari A, Dreno B and Quereux G: Early-onset vemurafenib-induced DRESS syndrome. Dermatology. 232:126–128. 2016.PubMed/NCBI View Article : Google Scholar
9	Anghel AG, Anghel I, Dumitru M and Soreanu CC: Respiratory and phonatory impairment due to iatrogenic vocal fold paralysis and paresis. A retrospective study of 188 patients. Rev Med Leg. 20:287–290. 2012.
10	Thongsri T, Chularojanamontri L and Pichler WJ: Cardiac involvement in DRESS syndrome. Asian Pac J Allergy Immunol. 35:3–10. 2017.PubMed/NCBI View Article : Google Scholar
11	Bommersbach TJ, Lapid MI, Leung JG, Cunningham JL, Rummans TA and Kung S: Management of psychotropic drug-induced DRESS syndrome: A systematic review. Mayo Clin Proc. 91:787–801. 2016.PubMed/NCBI View Article : Google Scholar
12	Misthaq AR, Pirasath S and Sugathapala AG: DRESS syndrome associated with sulfasalazine therapy. Jaffna Med J. 31:46–47. 2019.
13	Ozdemir O and Genc G: Drug reaction with eosinophilia and systemic symptoms syndrome associated with ampicillin-sulbactam and clindamyc in: A case report. Istanb Med J. 20:256–260. 2019.
14	Kang SY, Kim J, Ham J, Cho SH, Kang HR and Kim HY: Altered T cell and monocyte subsets in prolonged immune reconstitution inflammatory syndrome related with DRESS (drug reaction with eosinophilia and systemic symptoms). Asia Pac Allergy. 10(e2)2020.PubMed/NCBI View Article : Google Scholar
15	Pereira de Silva N, Piquioni P, Kochen S and Saidon P: Risk factors associated with DRESS syndrome produced by aromatic and non-aromatic antipiletic drugs. Eur J Clin Pharmacol. 67:463–470. 2011.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Severe DRESS syndrome after carbamazepine intake in a case with multiple addictions: A case report

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