Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Apple pomace and rosemary extract ameliorates hepatic steatosis in fructose-fed rats: Association with enhancing fatty acid oxidation and suppressing inflammation

  • Authors:
    • Ruojun Bai
    • Chunlin Yuan
    • Tongzhuang Wang
    • Li Liu
    • Jinxiu Li
    • Ying Lai
    • Haifei Li
    • Zhiwei Chen
    • Chunli Li
    • Dazhi Ke
    • Johji Yamahara
    • Ling Yao
    • Jian-Wei Wang
  • View Affiliations / Copyright

    Affiliations: Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Cure of Metabolic Diseases, College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, P.R. China, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, P.R. China, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, P.R. China, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China, Pharmafood Institute, Kyoto, Kansai 602-8136, Japan
    Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1975-1986
    |
    Published online on: June 19, 2020
       https://doi.org/10.3892/etm.2020.8910
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Apple pomace and rosemary (AR) have been reported to contain rich bioactive molecules, which have numerous metabolic effects. Our preliminary work revealed that AR ameliorated fructose‑induced insulin resistance in rats by modulating sarcolemmal CD36 and glucose transporter‑4. The present study aimed to further examine how AR improves metabolic disorders by investigating the effect of AR on hepatic steatosis induced by fructose overconsumption. The results demonstrated that AR (100 mg/kg daily by gavage for 5 weeks) attenuated chronic liquid fructose consumption‑induced increases in liver triglyceride content in rats. Mechanistically, reverse transcription‑quantitative PCR and western blot analysis results indicated that AR reversed fructose‑induced suppression of hepatic peroxisome proliferator‑activated receptor α, carnitine palmitoyl‑transferase 1α, sirtuin 1 and peroxisome proliferator‑activated receptor‑γ coactivator 1α, which were associated with the fatty acid oxidative (FAO) pathway. In addition, AR treatment decreased the expression levels of the pro‑inflammatory proteins NF‑κB and tumor necrosis factor‑α. However, AR had no effect on the genes related to lipogenesis and the very low‑density lipoprotein‑export pathway in rat liver. Thus, the present results suggested that AR treatment diminished long‑term fructose overconsumption‑induced fatty liver, which was associated with enhanced FAO and suppressed inflammation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Hassan K, Bhalla V, El Regal ME and A-Kader HH: Nonalcoholic fatty liver disease: A comprehensive review of a growing epidemic. World J Gastroenterol. 20:12082–12101. 2014.PubMed/NCBI View Article : Google Scholar

2 

Bray GA, Nielsen SJ and Popkin BM: Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr. 79:537–543. 2004.PubMed/NCBI View Article : Google Scholar

3 

Trindade CT, Kurokawa  , Cilmery Barreiros RC, Bossolan   and Grasiela  : High-fructose consumption and metabolic diseases. Fructose: Synthesis, Functions and Health Implications. 37–60. 2012.

4 

Kuzma JN, Cromer G, Hagman DK, Breymeyer KL, Roth CL, Foster-Schubert KE, Holte SE, Weigle DS and Kratz M: Consuming glucose-sweetened, not fructose-sweetened, beverages increases fasting insulin in healthy humans. Eur J Clin Nutr. 73:487–490. 2019.PubMed/NCBI View Article : Google Scholar

5 

Aeberli I, Hochuli M, Gerber PA, Sze L, Murer SB, Tappy L, Spinas GA and Berneis K: Moderate amounts of fructose consumption impair insulin sensitivity in healthy young men: A randomized controlled trial. Diabetes Care. 36:150–156. 2013.PubMed/NCBI View Article : Google Scholar

6 

Tappy L and Lê KA: Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev. 90:23–46. 2010.PubMed/NCBI View Article : Google Scholar

7 

DiNicolantonio JJ, Mehta V, Onkaramurthy N and O'Keefe JH: Fructose-induced inflammation and increased cortisol: A new mechanism for how sugar induces visceral adiposity. Prog Cardiovasc Dis. 61:3–9. 2018.PubMed/NCBI View Article : Google Scholar

8 

Zhu L, Baker SS, Liu W, Tao MH, Patel R, Nowak NJ and Baker RD: Lipid in the livers of adolescents with nonalcoholic steatohepatitis: Combined effects of pathways on steatosis. Metabolism. 60:1001–1011. 2011.PubMed/NCBI View Article : Google Scholar

9 

Kohjima M, Enjoji M, Higuchi N, Kato M, Kotoh K, Yoshimoto T, Fujino T, Yada M, Yada R, Harada N, et al: Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Int J Mol Med. 20:351–358. 2007.PubMed/NCBI

10 

Kasper W, ter Horst ID and Mireille J: Serlie: Fructose consumption, lipogenesis, and non-alcoholic fatty liver disease. Nutrients. 9(981)2017.PubMed/NCBI View Article : Google Scholar

11 

Shimomura I, Bashmakov Y, Ikemoto S, Horton JD, Brown MS and Goldstein JL: Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc Natl Acad Sci USA. 96:13656–13661. 1999.PubMed/NCBI View Article : Google Scholar

12 

Filhoulaud G, Guilmeau S, Dentin R, Girard J and Postic C: Novel insights into ChREBP regulation and function. Trends Endocrinol Metab. 24:257–268. 2013.PubMed/NCBI View Article : Google Scholar

13 

Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS and Goldstein JL: Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest. 99:846–854. 1997.PubMed/NCBI View Article : Google Scholar

14 

Higuchi N, Kato M, Shundo Y, Tajiri H, Tanaka M, Yamashita N, Kohjima M, Kotoh K, Nakamuta M, Takayanagi R, et al: Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. Hepatol Res. 38:1122–1129. 2008.PubMed/NCBI View Article : Google Scholar

15 

Xie Z, Li H, Wang K, Lin J, Wang Q, Zhao G, Jia W and Zhang Q: Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat. Metabolism. 59:554–560. 2010.PubMed/NCBI View Article : Google Scholar

16 

Postic C and Girard J: Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice. J Clin Invest. 118:829–838. 2008.PubMed/NCBI View Article : Google Scholar

17 

Ipsen DH, Lykkesfeldt J and Tveden-Nyborg P: Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease. Cell Mol Life Sci. 75:3313–3327. 2018.PubMed/NCBI View Article : Google Scholar

18 

Yamaguchi T, Omatsu N, Matsushita S and Osumi T: CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome. J Biol Chem. 279:30490–30497. 2004.PubMed/NCBI View Article : Google Scholar

19 

Ding J, Li M, Wan X, Jin X, Chen S, Yu C and Li Y: Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease. Sci Rep. 5(13729)2015.PubMed/NCBI View Article : Google Scholar

20 

Reddy JK and Hashimoto T: Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: An adaptive metabolic system. Annu Rev Nutr. 21:193–230. 2001.PubMed/NCBI View Article : Google Scholar

21 

Cao Y, Xue Y, Xue L, Jiang X, Wang X, Zhang Z, Yang J, Lu J, Zhang C, Wang W, et al: Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation. J Hepatol. 59:1299–1306. 2013.PubMed/NCBI View Article : Google Scholar

22 

Xu F, Gao Z, Zhang J, Rivera CA, Yin J, Weng J and Ye J: Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: A role of lipid mobilization and inflammation. Endocrinology. 151:2504–2514. 2010.PubMed/NCBI View Article : Google Scholar

23 

Hernández-Rodas MC, Valenzuela R, Echeverría F, Rincón-Cervera MÁ, Espinosa A, Illesca P, Muñoz P, Corbari A, Romero N, Gonzalez-Mañan D, et al: Supplementation with docosahexaenoic acid and extra virgin olive oil prevents liver steatosis induced by a high-fat diet in mice through PPAR-α and Nrf2 upregulation with concomitant SREBP-1c and NF-κB downregulation. Mol Nutr Food Res. 61(61)2017.PubMed/NCBI View Article : Google Scholar

24 

Valenzuela R, Illesca P, Echeverría F, Espinosa A, Rincón-Cervera MÁ, Ortiz M, Hernandez-Rodas MC, Valenzuela A and Videla LA: Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down-regulation. Food Funct. 8:1526–1537. 2017.PubMed/NCBI View Article : Google Scholar

25 

Munteanu MA, Nagy GA and Mircea PA: Current management of NAFLD. Clujul Med. 89:19–23. 2016.PubMed/NCBI View Article : Google Scholar

26 

Li S, Xu Y, Guo W, Chen F, Zhang C, Tan HY, Wang N and Feng Y: The impacts of herbal medicines and natural products on regulating the hepatic lipid metabolism. Front Pharmacol. 11(351)2020.PubMed/NCBI View Article : Google Scholar

27 

Kammerer DR, Kammerer J, Valet R and Carle R: Recovery of polyphenols from the by-products of plant food processing and application as valuable food ingredients. Food Res Int. 65:2–12. 2014. View Article : Google Scholar

28 

Hyson DA: A comprehensive review of apples and apple components and their relationship to human health. Adv Nutr. 2:408–420. 2011.PubMed/NCBI View Article : Google Scholar

29 

Bhushan S, Kalia K, Sharma M, Singh B and Ahuja PS: Processing of apple pomace for bioactive molecules. Crit Rev Biotechnol. 28:285–296. 2008.PubMed/NCBI View Article : Google Scholar

30 

Skinner RC, Warren DC, Lateef SN, Benedito VA and Tou JC: Apple pomace consumption favorably alters hepatic lipid metabolism in young female Sprague-Dawley rats fed a western diet. Nutrients. 10(10)2018.PubMed/NCBI View Article : Google Scholar

31 

Cho KD, Han CK and Lee BH: Loss of body weight and fat and improved lipid profiles in obese rats fed apple pomace or apple juice concentrate. J Med Food. 16:823–830. 2013.PubMed/NCBI View Article : Google Scholar

32 

Jeong JW, Shim JJ, Choi ID, Kim SH, Ra J, Ku HK, Lee DE, Kim TY, Jeung W, Lee JH, et al: Apple pomace extract improves endurance in exercise performance by increasing strength and weight of skeletal muscle. J Med Food. 18:1380–1386. 2015.PubMed/NCBI View Article : Google Scholar

33 

Makarova E, Górnaś P, Konrade I, Tirzite D, Cirule H, Gulbe A, Pugajeva I, Seglina D and Dambrova M: Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: A preliminary study. J Sci Food Agric. 95:560–568. 2015.PubMed/NCBI View Article : Google Scholar

34 

Bakirel T, Bakirel U, Keleş OU, Ulgen SG and Yardibi H: In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits. J Ethnopharmacol. 116:64–73. 2008. View Article : Google Scholar

35 

Nazem F, Farhangi N and Neshat-Gharamaleki M: Beneficial effects of endurance exercise with Rosmarinus officinalis Labiatae leaves extract on blood antioxidant enzyme activities and lipid peroxidation in streptozotocin-induced diabetic rats. Can J Diabetes. 39:229–234. 2015.PubMed/NCBI View Article : Google Scholar

36 

Ramadan KS, Khalil OA, Danial EN, Alnahdi HS and Ayaz NO: Hypoglycemic and hepatoprotective activity of Rosmarinus officinalis extract in diabetic rats. J Physiol Biochem. 69:779–783. 2013.PubMed/NCBI View Article : Google Scholar

37 

Jäger S, Trojan H, Kopp T, Laszczyk MN and Scheffler A: Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts. Molecules. 14:2016–2031. 2009.PubMed/NCBI View Article : Google Scholar

38 

Ma P, Yao L, Lin X, Gu T, Rong X, Batey R, Yamahara J, Wang J and Li Y: A mixture of apple pomace and rosemary extract improves fructose consumption-induced insulin resistance in rats: Modulation of sarcolemmal CD36 and glucose transporter-4. Am J Transl Res. 8:3791–3801. 2016.PubMed/NCBI

39 

Gao H, Guan T, Li C, Zuo G, Yamahara J, Wang J and Li Y: Treatment with ginger ameliorates fructose-induced fatty liver and hypertriglyceridemia in rats: Modulation of the hepatic carbohydrate response element-binding pro-tein-mediated pathway. Evid Based Complement Alternat Med. 2012(570948)2012.PubMed/NCBI View Article : Google Scholar

40 

Liu C and Li Y, Zuo G, Xu W, Gao H, Yang Y, Yamahara J, Wang J and Li Y: Oleanolic acid diminishes liquid fructose-induced fatty liver in rats: role of modulation of hepatic sterol regulatory element-binding protein-1c-mediated expression of genes responsible for de novo fatty acid synthesis. Evid Based Complement Alternat Med. 2013(534084)2013.PubMed/NCBI View Article : Google Scholar

41 

Wang J, Gao H, Ke D, Zuo G, Yang Y, Yamahara J and Li Y: Improvement of liquid fructose-induced adipose tissue insulin resistance by ginger treatment in rats is associated with suppression of adipose macrophage-related proinflammatory cytokines. Evid Based Complement Alternat Med. 2013(590376)2013.PubMed/NCBI View Article : Google Scholar

42 

Li Y, Wang J, Gu T, Yamahara J and Li Y: Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats. Toxicol Appl Pharmacol. 277:155–163. 2014.PubMed/NCBI View Article : Google Scholar

43 

Xing X, Li D, Chen D, Zhou L, Chonan R, Yamahara J, Wang J and Li Y: Mangiferin treatment inhibits hepatic expression of acyl-coenzyme A: Diacylglycerol acyltransferase-2 in fructose-fed spontaneously hypertensive rats: a link to amelioration of fatty liver. Toxicol Appl Pharmacol. 280:207–215. 2014.PubMed/NCBI View Article : Google Scholar

44 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

45 

Villena JA, Roy S, Sarkadi-Nagy E, Kim KH and Sul HS: Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: Ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem. 279:47066–47075. 2004.PubMed/NCBI View Article : Google Scholar

46 

van Rijn JM, Ardy RC, Kuloğlu Z, Härter B, van Haaften-Visser DY, van der Doef HP, van Hoesel M, Kansu A, van Vugt AH, Thian M, et al: Intestinal failure and aberrant lipid metabolism in patients with DGAT1 deficiency. Gastroenterology. 155(130-143.e15)2018.PubMed/NCBI View Article : Google Scholar

47 

Kraus-Friedmann N and Feng L: The role of intracellular Ca2+ in the regulation of gluconeogenesis. Metabolism. 45:389–403. 1996.PubMed/NCBI View Article : Google Scholar

48 

Horton JD, Bashmakov Y, Shimomura I and Shimano H: Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci USA. 95:5987–5992. 1998.PubMed/NCBI View Article : Google Scholar

49 

Vasiljević A, Bursać B, Djordjevic A, Milutinović DV, Nikolić M, Matić G and Veličković N: Hepatic inflammation induced by high-fructose diet is associated with altered 11βHSD1 expression in the liver of Wistar rats. Eur J Nutr. 53:1393–1402. 2014.PubMed/NCBI View Article : Google Scholar

50 

Mary C Sugden, Paul W Caton and Mark J Holness: PPAR control: It's SIRTainly as easy as PGC. J Endocrinol. 204:93–104. 2010.PubMed/NCBI View Article : Google Scholar

51 

Lee WJ, Kim M, Park HS, Kim HS, Jeon MJ, Oh KS, Koh EH, Won JC, Kim MS, Oh GT, et al: AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1. Biochem Biophys Res Commun. 340:291–295. 2006.PubMed/NCBI View Article : Google Scholar

52 

Haigis MC and Sinclair DA: Mammalian sirtuins: Biological insights and disease relevance. Annu Rev Pathol. 5:253–295. 2010.PubMed/NCBI View Article : Google Scholar

53 

Hall JA, Dominy JE, Lee Y and Puigserver P: The sirtuin family's role in aging and age-associated pathologies. J Clin Invest. 123:973–979. 2013.PubMed/NCBI View Article : Google Scholar

54 

Houtkooper RH, Cantó C, Wanders RJ and Auwerx J: The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways. Endocr Rev. 31:194–223. 2010.PubMed/NCBI View Article : Google Scholar

55 

Michishita E, Park JY, Burneskis JM, Barrett JC and Horikawa I: Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell. 16:4623–4635. 2005.PubMed/NCBI View Article : Google Scholar

56 

Verdin E, Hirschey MD, Finley LW and Haigis MC: Sirtuin regulation of mitochondria: Energy production, apoptosis, and signaling. Trends Biochem Sci. 35:669–675. 2010.PubMed/NCBI View Article : Google Scholar

57 

Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, et al: Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology. 63:1190–1204. 2016.PubMed/NCBI View Article : Google Scholar

58 

Cantó C, Menzies KJ and Auwerx J: NAD(+) metabolism and the control of energy homeostasis: A balancing act between mitochondria and the nucleus. Cell Metab. 22:31–53. 2015. View Article : Google Scholar

59 

Ruan Q, Ruan J, Zhang W, Qian F and Yu Z: Targeting NAD+ degradation: The therapeutic potential of flavonoids for Alzheimer's disease and cognitive frailty. Pharmacol Res. 128:345–358. 2018.PubMed/NCBI View Article : Google Scholar

60 

Echeverría F, Valenzuela R, Bustamante A, Álvarez D, Ortiz M, Espinosa A, Illesca P, Gonzalez-Mañan D and Videla LA: High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: Attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration. Food Funct. 10:6170–6183. 2019.PubMed/NCBI View Article : Google Scholar

61 

Jäger S, Handschin C, St-Pierre J and Spiegelman BM: AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci USA. 104:12017–12022. 2007.PubMed/NCBI View Article : Google Scholar

62 

Wahli W and Michalik L: PPARs at the crossroads of lipid signaling and inflammation. Trends Endocrinol Metab. 23:351–363. 2012.PubMed/NCBI View Article : Google Scholar

63 

Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, Tian B, Wagner T, Vatner SF and Sadoshima J: Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res. 100:1512–1521. 2007.PubMed/NCBI View Article : Google Scholar

64 

Wan X, Wen JJ, Koo SJ, Liang LY and Garg NJ: SIRT1-PGC1α-NFκB Pathway of oxidative and inflammatory stress during Trypanosoma cruzi infection: Benefits of SIRT1-targeted therapy in improving heart function in chagas disease. PLoS Pathog. 12(e1005954)2016.PubMed/NCBI View Article : Google Scholar

65 

Köhler UA, Böhm F, Rolfs F, Egger M, Hornemann T, Pasparakis M, Weber A and Werner S: NF-κB/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma. J Hepatol. 64:94–102. 2016.PubMed/NCBI View Article : Google Scholar

66 

Bayram B, Ozcelik B, Grimm S, Roeder T, Schrader C, Ernst IM, Wagner AE, Grune T, Frank J and Rimbach G: A diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression. Rejuvenation Res. 15:71–81. 2012.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Bai R, Yuan C, Wang T, Liu L, Li J, Lai Y, Li H, Chen Z, Li C, Ke D, Ke D, et al: Apple pomace and rosemary extract ameliorates hepatic steatosis in fructose-fed rats: Association with enhancing fatty acid oxidation and suppressing inflammation. Exp Ther Med 20: 1975-1986, 2020.
APA
Bai, R., Yuan, C., Wang, T., Liu, L., Li, J., Lai, Y. ... Wang, J. (2020). Apple pomace and rosemary extract ameliorates hepatic steatosis in fructose-fed rats: Association with enhancing fatty acid oxidation and suppressing inflammation. Experimental and Therapeutic Medicine, 20, 1975-1986. https://doi.org/10.3892/etm.2020.8910
MLA
Bai, R., Yuan, C., Wang, T., Liu, L., Li, J., Lai, Y., Li, H., Chen, Z., Li, C., Ke, D., Yamahara, J., Yao, L., Wang, J."Apple pomace and rosemary extract ameliorates hepatic steatosis in fructose-fed rats: Association with enhancing fatty acid oxidation and suppressing inflammation". Experimental and Therapeutic Medicine 20.3 (2020): 1975-1986.
Chicago
Bai, R., Yuan, C., Wang, T., Liu, L., Li, J., Lai, Y., Li, H., Chen, Z., Li, C., Ke, D., Yamahara, J., Yao, L., Wang, J."Apple pomace and rosemary extract ameliorates hepatic steatosis in fructose-fed rats: Association with enhancing fatty acid oxidation and suppressing inflammation". Experimental and Therapeutic Medicine 20, no. 3 (2020): 1975-1986. https://doi.org/10.3892/etm.2020.8910
Copy and paste a formatted citation
x
Spandidos Publications style
Bai R, Yuan C, Wang T, Liu L, Li J, Lai Y, Li H, Chen Z, Li C, Ke D, Ke D, et al: Apple pomace and rosemary extract ameliorates hepatic steatosis in fructose-fed rats: Association with enhancing fatty acid oxidation and suppressing inflammation. Exp Ther Med 20: 1975-1986, 2020.
APA
Bai, R., Yuan, C., Wang, T., Liu, L., Li, J., Lai, Y. ... Wang, J. (2020). Apple pomace and rosemary extract ameliorates hepatic steatosis in fructose-fed rats: Association with enhancing fatty acid oxidation and suppressing inflammation. Experimental and Therapeutic Medicine, 20, 1975-1986. https://doi.org/10.3892/etm.2020.8910
MLA
Bai, R., Yuan, C., Wang, T., Liu, L., Li, J., Lai, Y., Li, H., Chen, Z., Li, C., Ke, D., Yamahara, J., Yao, L., Wang, J."Apple pomace and rosemary extract ameliorates hepatic steatosis in fructose-fed rats: Association with enhancing fatty acid oxidation and suppressing inflammation". Experimental and Therapeutic Medicine 20.3 (2020): 1975-1986.
Chicago
Bai, R., Yuan, C., Wang, T., Liu, L., Li, J., Lai, Y., Li, H., Chen, Z., Li, C., Ke, D., Yamahara, J., Yao, L., Wang, J."Apple pomace and rosemary extract ameliorates hepatic steatosis in fructose-fed rats: Association with enhancing fatty acid oxidation and suppressing inflammation". Experimental and Therapeutic Medicine 20, no. 3 (2020): 1975-1986. https://doi.org/10.3892/etm.2020.8910
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team