The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study

  • Authors:
    • Masatsugu Hiraki
    • Atsushi Miyoshi
    • Eiji Sadashima
    • Yukio Shinkai
    • Michio Yasunami
    • Tatsuya Manabe
    • Kenji Kitahara
    • Hirokazu Noshiro
  • View Affiliations

  • Published online on: June 19, 2020     https://doi.org/10.3892/etm.2020.8919
  • Pages: 2298-2304
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Abstract

Postoperative pancreatic fistula (PF) is a major and serious complication that occurs after pancreaticoduodenectomy (PD). The aim of the current study was to evaluate the use of a novel biomarker, presepsin, for predicting clinically relevant postoperative pancreatic fistula (CR‑POPF) after PD. A prospective pilot study was conducted using 30 consecutive patients who underwent PD. Risk factors and candidates for predictive biomarkers for CR‑POPF were statistically analyzed. CR‑POPF (grade B and C; determined according to the guidelines of the International Study Group of Pancreatic Fistula) occurred in 15 patients (50%). Univariate analysis revealed that certain underlying conditions, including non‑pancreatic cancer, smaller pancreatic ducts and soft pancreas texture were significantly associated with CR‑POPF (P=0.005, P=0.004 and P=0.014, respectively). Furthermore, on day 1 post surgery (POD1), white blood cell count (P=0.040), levels of serum amylase (P=0.002) and serum presepsin (P=0.012), and the concentration of presepsin in drainage fluid (P<0.001) were significantly increased in CR‑POPF compared with non‑CR‑POPF cases. Receiver operating characteristic curve analyses revealed that, on POD1, serum amylase and the concentration of presepsin in drainage fluid had an area under the curve value exceeding 0.8. A multivariate logistic regression analysis revealed that a higher concentration of presepsin in the drainage fluid was an independent predictive marker for CR‑POPF (odds ratio, 14.503; 95% confidence interval, 1.750‑120.229; P=0.013). To the best of our knowledge, the present study demonstrated for the first time that presepsin concentration in drainage fluid is a useful marker of CR‑POPF after PD.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Hiraki M, Miyoshi A, Sadashima E, Shinkai Y, Yasunami M, Manabe T, Kitahara K and Noshiro H: The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study. Exp Ther Med 20: 2298-2304, 2020
APA
Hiraki, M., Miyoshi, A., Sadashima, E., Shinkai, Y., Yasunami, M., Manabe, T. ... Noshiro, H. (2020). The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study. Experimental and Therapeutic Medicine, 20, 2298-2304. https://doi.org/10.3892/etm.2020.8919
MLA
Hiraki, M., Miyoshi, A., Sadashima, E., Shinkai, Y., Yasunami, M., Manabe, T., Kitahara, K., Noshiro, H."The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study". Experimental and Therapeutic Medicine 20.3 (2020): 2298-2304.
Chicago
Hiraki, M., Miyoshi, A., Sadashima, E., Shinkai, Y., Yasunami, M., Manabe, T., Kitahara, K., Noshiro, H."The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2298-2304. https://doi.org/10.3892/etm.2020.8919