Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study

  • Authors:
    • Masatsugu Hiraki
    • Atsushi Miyoshi
    • Eiji Sadashima
    • Yukio Shinkai
    • Michio Yasunami
    • Tatsuya Manabe
    • Kenji Kitahara
    • Hirokazu Noshiro
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Saga Medical Center Koseikan, Saga 840‑8571, Japan, Life Science Research Institution, Saga Medical Center Koseikan, Saga 840‑8571, Japan, Clinical Laboratory, Saga Medical Center Koseikan, Saga 840‑8571, Japan, Department of Surgery, Saga University Faculty of Medicine, Saga 849‑8501, Japan
  • Pages: 2298-2304
    |
    Published online on: June 19, 2020
       https://doi.org/10.3892/etm.2020.8919
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Postoperative pancreatic fistula (PF) is a major and serious complication that occurs after pancreaticoduodenectomy (PD). The aim of the current study was to evaluate the use of a novel biomarker, presepsin, for predicting clinically relevant postoperative pancreatic fistula (CR‑POPF) after PD. A prospective pilot study was conducted using 30 consecutive patients who underwent PD. Risk factors and candidates for predictive biomarkers for CR‑POPF were statistically analyzed. CR‑POPF (grade B and C; determined according to the guidelines of the International Study Group of Pancreatic Fistula) occurred in 15 patients (50%). Univariate analysis revealed that certain underlying conditions, including non‑pancreatic cancer, smaller pancreatic ducts and soft pancreas texture were significantly associated with CR‑POPF (P=0.005, P=0.004 and P=0.014, respectively). Furthermore, on day 1 post surgery (POD1), white blood cell count (P=0.040), levels of serum amylase (P=0.002) and serum presepsin (P=0.012), and the concentration of presepsin in drainage fluid (P<0.001) were significantly increased in CR‑POPF compared with non‑CR‑POPF cases. Receiver operating characteristic curve analyses revealed that, on POD1, serum amylase and the concentration of presepsin in drainage fluid had an area under the curve value exceeding 0.8. A multivariate logistic regression analysis revealed that a higher concentration of presepsin in the drainage fluid was an independent predictive marker for CR‑POPF (odds ratio, 14.503; 95% confidence interval, 1.750‑120.229; P=0.013). To the best of our knowledge, the present study demonstrated for the first time that presepsin concentration in drainage fluid is a useful marker of CR‑POPF after PD.
View Figures

Figure 1

View References

1 

Rosso E, Casnedi S, Pessaux P, Oussoultzoglou E, Panaro F, Mahfud M, Jaeck D and Bachellier P: The role of ‘fatty pancreas’ and of BMI in the occurrence of pancreatic fistula after pancreaticoduodenectomy. J Gastrointest Surg. 13:1845–1851. 2009.

2 

Kawai M, Kondo S, Yamaue H, Wada K, Sano K, Motoi F, Unno M, Satoi S, Kwon AH, Hatori T, et al: Predictive risk factors for clinically relevant pancreatic fistula analyzed in 1,239 patients with pancreaticoduodenectomy: Multicenter data collection as a project study of pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci. 18:601–608. 2011.PubMed/NCBI View Article : Google Scholar

3 

Kastenberg ZJ, Morton JM, Visser BC, Norton JA and Poultsides GA: Hospital readmission after a pancreaticoduodenectomy: An emerging quality metric? HPB (Oxford). 15:142–148. 2013.PubMed/NCBI View Article : Google Scholar

4 

Kanda M, Fujii T, Suenaga M, Takami H, Hattori M, Inokawa Y, Yamada S, Nakayama G, Sugimoto H, Koike M, et al: Estimated pancreatic parenchymal remnant volume accurately predicts clinically relevant pancreatic fistula after pancreatoduodenectomy. Surgery. 156:601–610. 2014.PubMed/NCBI View Article : Google Scholar

5 

Dalla Valle R, De Bellis M, Pedrazzi G, Lamecchi L, Bianchi G, Pellegrino C and Iaria M: Can early serum lipase measurement be routinely implemented to rule out clinically significant pancreatic fistula after pancreaticoduodenectomy? Int J Surg. 21 (Suppl 1):S50–S54. 2015.PubMed/NCBI View Article : Google Scholar

6 

Partelli S, Pecorelli N, Muffatti F, Belfiori G, Crippa S, Piazzai F, Castoldi R, Marmorale C, Balzano G and Falconi M: Early postoperative prediction of clinically relevant pancreatic fistula after pancreaticoduodenectomy: Usefulness of C-reactive Protein. HPB (Oxford). 19:580–586. 2017.PubMed/NCBI View Article : Google Scholar

7 

Okabayashi T, Maeda H, Nishimori I, Sugimoto T, Ikeno T and Hanazaki K: Pancreatic fistula formation after pancreaticooduodenectomy; for prevention of this deep surgical site infection after pancreatic surgery. Hepatogastroenterology. 56:519–523. 2009.PubMed/NCBI

8 

Nagakawa Y, Matsudo T, Hijikata Y, Kikuchi S, Bunso K, Suzuki Y, Kasuya K and Tsuchida A: Bacterial contamination in ascitic fluid is associated with the development of clinically relevant pancreatic fistula after pancreatoduodenectomy. Pancreas. 42:701–706. 2013.PubMed/NCBI View Article : Google Scholar

9 

Cloyd JM, Kastenberg ZJ, Visser BC, Poultsides GA and Norton JA: Postoperative serum amylase predicts pancreatic fistula formation following pancreaticoduodenectomy. J Gastrointest Surg. 18:348–353. 2014.PubMed/NCBI View Article : Google Scholar

10 

Palani Velu LK, Chandrabalan VV, Jabbar S, McMillan DC, McKay CJ, Carter CR, Jamieson NB and Dickson EJ: Serum amylase on the night of surgery predicts clinically significant pancreatic fistula after pancreaticoduodenectomy. HPB (Oxford). 16:610–619. 2014.PubMed/NCBI View Article : Google Scholar

11 

Yaegashi Y, Shirakawa K, Sato N, Suzuki Y, Kojika M, Imai S, Takahashi G, Miyata M, Furusako S and Endo S: Evaluation of a newly identified soluble CD14 subtype as a marker for sepsis. J Infect Chemother. 11:234–238. 2005.PubMed/NCBI View Article : Google Scholar

12 

Chenevier-Gobeaux C, Borderie D, Weiss N, Mallet-Coste T and Claessens YE: Presepsin (sCD14-ST), an innate immune response marker in sepsis. Clin Chim Acta. 450:97–103. 2015.PubMed/NCBI View Article : Google Scholar

13 

Wright SD, Ramos RA, Tobias PS, Ulevitch RJ and Mathison JC: CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science. 249:1431–1433. 1990.PubMed/NCBI View Article : Google Scholar

14 

Yamashita K, Sasaki T, Itoh R, Kato D, Hatano N, Soejima T, Ishii K, Takenawa T, Hiromatsu K and Yamashita Y: Pancreatic fistulae secondary to trypsinogen activation by Pseudomonas aeruginosa infection after pancreatoduodenectomy. J Hepatobiliary Pancreat Sci. 22:454–462. 2015.PubMed/NCBI View Article : Google Scholar

15 

Fujii T, Sugimoto H, Yamada S, Kanda M, Suenaga M, Takami H, Hattori M, Inokawa Y, Nomoto S, Fujiwara M and Kodera Y: Modified Blumgart anastomosis for pancreaticojejunostomy: Technical improvement in matched historical control study. J Gastrointest Surg. 18:1108–1115. 2014.PubMed/NCBI View Article : Google Scholar

16 

Bassi C, Marchegiani G, Dervenis C, Sarr M, Abu Hilal M, Adham M, Allen P, Andersson R, Asbun HJ, Besselink MG, et al: The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 years after. Surgery. 161:584–591. 2017.PubMed/NCBI View Article : Google Scholar

17 

Del Chiaro M, Rangelova E, Ansorge C, Blomberg J and Segersvard R: Impact of body mass index for patients undergoing pancreaticoduodenectomy. World J Gastrointest Pathophysiol. 4:37–42. 2013.PubMed/NCBI View Article : Google Scholar

18 

Lee SE, Jang JY, Lim CS, Kang MJ, Kim SH, Kim MA and Kim SW: Measurement of pancreatic fat by magnetic resonance imaging: Predicting the occurrence of pancreatic fistula after pancreatoduodenectomy. Ann Surg. 251:932–936. 2010.PubMed/NCBI View Article : Google Scholar

19 

Facy O, Chalumeau C, Poussier M, Binquet C, Rat P and Ortega-Deballon P: Diagnosis of postoperative pancreatic fistula. Br J Surg. 99:1072–1075. 2012.PubMed/NCBI View Article : Google Scholar

20 

Whitcomb DC and Lowe ME: Human pancreatic digestive enzymes. Dig Dis Sci. 52:1–17. 2007.PubMed/NCBI View Article : Google Scholar

21 

Kawai M, Tani M, Terasawa H, Ina S, Hirono S, Nishioka R, Miyazawa M, Uchiyama K and Yamaue H: Early removal of prophylactic drains reduces the risk of intra-abdominal infections in patients with pancreatic head resection: Prospective study for 104 consecutive patients. Ann Surg. 244:1–7. 2006.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hiraki M, Miyoshi A, Sadashima E, Shinkai Y, Yasunami M, Manabe T, Kitahara K and Noshiro H: The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study. Exp Ther Med 20: 2298-2304, 2020.
APA
Hiraki, M., Miyoshi, A., Sadashima, E., Shinkai, Y., Yasunami, M., Manabe, T. ... Noshiro, H. (2020). The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study. Experimental and Therapeutic Medicine, 20, 2298-2304. https://doi.org/10.3892/etm.2020.8919
MLA
Hiraki, M., Miyoshi, A., Sadashima, E., Shinkai, Y., Yasunami, M., Manabe, T., Kitahara, K., Noshiro, H."The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study". Experimental and Therapeutic Medicine 20.3 (2020): 2298-2304.
Chicago
Hiraki, M., Miyoshi, A., Sadashima, E., Shinkai, Y., Yasunami, M., Manabe, T., Kitahara, K., Noshiro, H."The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2298-2304. https://doi.org/10.3892/etm.2020.8919
Copy and paste a formatted citation
x
Spandidos Publications style
Hiraki M, Miyoshi A, Sadashima E, Shinkai Y, Yasunami M, Manabe T, Kitahara K and Noshiro H: The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study. Exp Ther Med 20: 2298-2304, 2020.
APA
Hiraki, M., Miyoshi, A., Sadashima, E., Shinkai, Y., Yasunami, M., Manabe, T. ... Noshiro, H. (2020). The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study. Experimental and Therapeutic Medicine, 20, 2298-2304. https://doi.org/10.3892/etm.2020.8919
MLA
Hiraki, M., Miyoshi, A., Sadashima, E., Shinkai, Y., Yasunami, M., Manabe, T., Kitahara, K., Noshiro, H."The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study". Experimental and Therapeutic Medicine 20.3 (2020): 2298-2304.
Chicago
Hiraki, M., Miyoshi, A., Sadashima, E., Shinkai, Y., Yasunami, M., Manabe, T., Kitahara, K., Noshiro, H."The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2298-2304. https://doi.org/10.3892/etm.2020.8919
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team