Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2020 Volume 20 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

MicroRNA‑27a inhibits trophoblast cell migration and invasion by targeting SMAD2: Potential role in preeclampsia

  • Authors:
    • Wenfei Zheng
    • Aihua Chen
    • Huaijie Yang
    • Li Hong
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Gynecology and Obstetrics, The People's Hospital of China Three Gorges University, Yichang, Hubei 443000, P.R. China
  • Pages: 2262-2269
    |
    Published online on: June 24, 2020
       https://doi.org/10.3892/etm.2020.8924
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Preeclampsia (PE) is a severe idiopathic obstetric complication that occurs worldwide. Insufficient trophoblast invasion is a characteristic of the pathogenesis of PE. MicroRNA‑27a (miR‑27a) has been reported to be highly expressed in PE placentas. The aim of the present study was to investigate the role and underlying mechanisms of miR‑27a in the pathogenesis of PE. The expression level of miR‑27a was evaluated in the placenta and serum from patients with PE and healthy pregnant women. Cell Counting Kit‑8 and flow cytometry assays were performed to detect human HTR‑8/SVneo trophoblast proliferation and apoptosis after miR‑27a overexpression or inhibition. In addition, Transwell assays were used to measure cell migration and invasion. A luciferase reporter assay was performed to determine the interaction between miR‑27a and SMAD2. The present results suggested that miR‑27a expression level was significantly increased in PE placentas and serum. In addition, miR‑27a overexpression suppressed cell migratory and invasive abilities, impaired proliferation and promoted apoptosis in human trophoblasts. It was demonstrated that miR‑27a may target SMAD and contribute to trophoblast invasion. Collectively, the results of the present study suggested that miR‑27a inhibited trophoblast cell migration and invasion by targeting SMAD2, thus presenting a promising therapeutic target for PE.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Ghulmiyyah L and Sibai B: Maternal mortality from preeclampsia/eclampsia. Semin Perinatol. 36:56–59. 2012.PubMed/NCBI View Article : Google Scholar

2 

Mol BWJ, Roberts CT, Thangaratinam S, Magee LA, de Groot CJM and Hofmeyr GJ: Pre-eclampsia. Lancet. 387:999–1011. 2016.PubMed/NCBI View Article : Google Scholar

3 

Tenorio MB, Ferreira RC, Moura FA, Bueno NB, de Oliveira ACM and Goulart MOF: Cross-talk between oxidative stress and inflammation in preeclampsia. Oxid Med Cell Longev. 2019(8238727)2019.PubMed/NCBI View Article : Google Scholar

4 

Sircar M, Thadhani R and Karumanchi SA: Pathogenesis of preeclampsia. Curr Opin Nephrol Hypertens. 24:131–138. 2015.PubMed/NCBI View Article : Google Scholar

5 

Bhorat I: Pre-eclampsia and the foetus: A cardiovascular perspective. Cardiovasc J Afr. 29:387–393. 2018.PubMed/NCBI View Article : Google Scholar

6 

Staun-Ram E and Shalev E: Human trophoblast function during the implantation process. Reprod Biol Endocrinol. 3(56)2005.PubMed/NCBI View Article : Google Scholar

7 

Rebahi H, Elizabeth Still M, Faouzi Y and Rhassane El Adib A: Risk factors for eclampsia in pregnant women with preeclampsia and positive neurosensory signs. Turk J Obstet Gynecol. 15:227–234. 2018.PubMed/NCBI View Article : Google Scholar

8 

Xu T, Ni MM, Xing-LI Li XF, Meng XM, Huang C and Li J: NLRC5 regulates TGF-β1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis. Int J Biochem Cell Biol. 70:92–104. 2016.PubMed/NCBI View Article : Google Scholar

9 

Miyazono K, Suzuki H and Imamura T: Regulation of TGF-beta signaling and its roles in progression of tumors. Cancer Sci. 94:230–234. 2003.PubMed/NCBI View Article : Google Scholar

10 

Kawamoto K, Pahuja A, Hering BJ and Bansal-Pakala P: Transforming growth factor beta 1 (TGF-beta1) and rapamycin synergize to effectively suppress human T cell responses via upregulation of FoxP3+ Tregs. Transpl Immunol. 23:28–33. 2010.PubMed/NCBI View Article : Google Scholar

11 

Serban AI, Stanca L, Geicu OI, Munteanu MC and Dinischiotu A: RAGE and TGF-β1 cross-talk regulate extracellular matrix turnover and cytokine synthesis in AGEs exposed fibroblast cells. PLoS One. 11(e0152376)2016.PubMed/NCBI View Article : Google Scholar

12 

Seoane J and Gomis RR: TGF-β family signaling in tumor suppression and cancer progression. Cold Spring Harb Perspect Biol. 9(a022277)2017.PubMed/NCBI View Article : Google Scholar

13 

Katz LH, Likhter M, Jogunoori W, Belkin M, Ohshiro K and Mishra L: TGF-β signaling in liver and gastrointestinal cancers. Cancer Lett. 379:166–172. 2016.PubMed/NCBI View Article : Google Scholar

14 

Zhang L, Zhou F, Garcia de Vinuesa A, de Kruijf EM, Mesker WE, Hui L, Drabsch Y, Li Y, Bauer A, Rousseau A, et al: TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis. Mol Cell. 51:559–572. 2013.PubMed/NCBI View Article : Google Scholar

15 

Lash GE, Otun HA, Innes BA, Bulmer JN, Searle RF and Robson SC: Inhibition of trophoblast cell invasion by TGFB1, 2, and 3 is associated with a decrease in active proteases. Biol Reprod. 73:374–381. 2005.PubMed/NCBI View Article : Google Scholar

16 

Zhao MR, Qiu W, Li YX, Zhang ZB, Li D and Wang YL: Dual effect of transforming growth factor beta1 on cell adhesion and invasion in human placenta trophoblast cells. Reproduction. 132:333–341. 2006.PubMed/NCBI View Article : Google Scholar

17 

Albers RE, Selesniemi K, Natale DRC and Brown TL: TGF-β induces Smad2 phosphorylation, ARE induction, and trophoblast differentiation. Int J Stem Cells. 11:111–120. 2018.PubMed/NCBI View Article : Google Scholar

18 

Attisano L and Wrana JL: Signal transduction by the TGF-beta superfamily. Science. 296:1646–1647. 2002.PubMed/NCBI View Article : Google Scholar

19 

Huang Z, Li S, Fan W and Ma Q: Transforming growth factor β 1 promotes invasion of human JEG-3 trophoblast cells via TGF-β/Smad3 signaling pathway. Oncotarget. 8:33560–33570. 2017.PubMed/NCBI View Article : Google Scholar

20 

Zhang J, Zhang X, Xie F, Zhang Z, van Dam H, Zhang L and Zhou F: The regulation of TGF-β/SMAD signaling by protein deubiquitination. Protein Cell. 5:503–517. 2014.PubMed/NCBI View Article : Google Scholar

21 

Chae DK, Ban E, Yoo YS, Kim EE, Baik JH and Song EJ: MIR-27a regulates the TGF-β signaling pathway by targeting SMAD2 and SMAD4 in lung cancer. Mol Carcinog. 56:1992–1998. 2017.PubMed/NCBI View Article : Google Scholar

22 

Marmol I, Sanchez-de-Diego C, Pradilla Dieste A, Cerrada E and Rodriguez Yoldi MJ: Colorectal carcinoma: A general overview and future perspectives in colorectal cancer. Int J Mol Sci. 18(E197)2017.PubMed/NCBI View Article : Google Scholar

23 

Tang YN, Ding WQ, Guo XJ, Yuan XW, Wang DM and Song JG: Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis. Nat Commun. 6(8230)2015.PubMed/NCBI View Article : Google Scholar

24 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004.PubMed/NCBI View Article : Google Scholar

25 

Guo L, Liu Y, Guo Y, Yang Y and Chen B: MicroRNA-423-5p inhibits the progression of trophoblast cells via targeting IGF2BP1. Placenta. 74:1–8. 2018.PubMed/NCBI View Article : Google Scholar

26 

Osipov ID, Zaporozhchenko IA, Bondar AA, Zaripov MM, Voytsitskiy VE, Vlassov VV, Laktionov PP and Morozkin ES: Cell-free miRNA-141 and miRNA-205 as prostate cancer biomarkers. Adv Exp Med Biol. 924:9–12. 2016.PubMed/NCBI View Article : Google Scholar

27 

Peng G, Liao Y and Shen C: miRNA-429 inhibits astrocytoma proliferation and invasion by targeting BMI1. Pathol Oncol Res. 23:369–376. 2017.PubMed/NCBI View Article : Google Scholar

28 

Vaiman D: Genes, epigenetics and miRNA regulation in the placenta. Placenta. 52:127–133. 2017.PubMed/NCBI View Article : Google Scholar

29 

Li P, Guo W, Du L, Zhao J, Wang Y, Liu L, Hu Y and Hou Y: microRNA-29b contributes to pre-eclampsia through its effects on apoptosis, invasion and angiogenesis of trophoblast cells. Clin Sci (Lond). 124:27–40. 2013.PubMed/NCBI View Article : Google Scholar

30 

Niu ZR, Han T, Sun XL, Luan LX, Gou WL and Zhu XM: MicroRNA-30a-3p is overexpressed in the placentas of patients with preeclampsia and affects trophoblast invasion and apoptosis by its effects on IGF-1. Am J Obstet Gynecol. 218:249.e1–249.e12. 2018.PubMed/NCBI View Article : Google Scholar

31 

Fu G, Ye G, Nadeem L, Ji L, Manchanda T, Wang Y, Zhao Y, Qiao J, Wang YL, Lye S, et al: MicroRNA-376c impairs transforming growth factor-β and nodal signaling to promote trophoblast cell proliferation and invasion. Hypertension. 61:864–872. 2013.PubMed/NCBI View Article : Google Scholar

32 

Salah Z, Arafeh R, Maximov V, Galasso M, Khawaled S, Abou-Sharieha S, Volinia S, Jones KB, Croce CM and Aqeilan RI: miR-27a and miR-27a* contribute to metastatic properties of osteosarcoma cells. Oncotarget. 6:4920–4935. 2015.PubMed/NCBI View Article : Google Scholar

33 

Song J, Li Y and An RF: Identification of early-onset preeclampsia-related genes and MicroRNAs by bioinformatics approaches. Reprod Sci. 22:954–963. 2015.PubMed/NCBI View Article : Google Scholar

34 

Yang S, Li H, Ge Q, Guo L and Chen F: Deregulated microRNA species in the plasma and placenta of patients with preeclampsia. Mol Med Rep. 12:527–534. 2015.PubMed/NCBI View Article : Google Scholar

35 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

36 

Jairajpuri DS and Almawi WY: MicroRNA expression pattern in pre-eclampsia (Review). Mol Med Rep. 13:2351–2358. 2016.PubMed/NCBI View Article : Google Scholar

37 

Pineles BL, Romero R, Montenegro D, Tarca AL, Han YM, Kim YM, Draghici S, Espinoza J, Kusanovic JP, Mittal P, et al: Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia. Am J Obstet Gynecol. 196:261.e1–6. 2007.PubMed/NCBI View Article : Google Scholar

38 

Ji L, Zhang L, Li Y, Guo L, Cao N, Bai Z, Song Y, Xu Z, Zhang J, Liu C and Ma X: MiR-136 contributes to pre-eclampsia through its effects on apoptosis and angiogenesis of mesenchymal stem cells. Placenta. 50:102–109. 2017.PubMed/NCBI View Article : Google Scholar

39 

Guo M, Zhao X, Yuan X and Li P: Elevated microRNA-34a contributes to trophoblast cell apoptosis in preeclampsia by targeting BCL-2. J Hum Hypertens. 31:815–820. 2017.PubMed/NCBI View Article : Google Scholar

40 

Kim J, Fiesel FC, Belmonte KC, Hudec R, Wang WX, Kim C, Nelson PT, Springer W and Kim J: miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1). Mol Neurodegener. 11(55)2016.PubMed/NCBI View Article : Google Scholar

41 

Zhao Y, Dong D, Reece EA, Wang AR and Yang P: Oxidative stress-induced miR-27a targets the redox gene nuclear factor erythroid 2-related factor 2 in diabetic embryopathy. Am J Obstet Gynecol. 218:136.e1–136.e10. 2018.PubMed/NCBI View Article : Google Scholar

42 

Yao F, Yu Y, Feng L, Li J, Zhang M, Lan X, Yan X, Liu Y, Guan F, Zhang M and Chen L: Adipogenic miR-27a in adipose tissue upregulates macrophage activation via inhibiting PPARgamma of insulin resistance induced by high-fat diet-associated obesity. Exp Cell Res. 355:105–112. 2017.PubMed/NCBI View Article : Google Scholar

43 

Danza K, Silvestris N, Simone G, Signorile M, Saragoni L, Brunetti O, Monti M, Mazzotta A, De Summa S, Mangia A and Tommasi S: Role of miR-27a, miR-181a and miR-20b in gastric cancer hypoxia-induced chemoresistance. Cancer Biol Ther. 17:400–406. 2016.PubMed/NCBI View Article : Google Scholar

44 

Derynck R and Zhang YE: Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 425:577–584. 2003.PubMed/NCBI View Article : Google Scholar

45 

Khalil H, Kanisicak O, Prasad V, Correll RN, Fu X, Schips T, Vagnozzi RJ, Liu R, Huynh T, Lee SJ, et al: Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosis. J Clin Invest. 127:3770–3783. 2017.PubMed/NCBI View Article : Google Scholar

46 

Fu H, He Y, Qi L, Chen L, Luo Y, Chen L, Li Y, Zhang N and Guo H: cPLA2α activates PI3K/AKT and inhibits Smad2/3 during epithelial-mesenchymal transition of hepatocellular carcinoma cells. Cancer Lett. 403:260–270. 2017.PubMed/NCBI View Article : Google Scholar

47 

Lu Y, Wang L, Li H, Li Y, Ruan Y, Lin D, Yang M, Jin X, Guo Y, Zhang X and Quan C: SMAD2 inactivation inhibits CLDN6 methylation to suppress migration and invasion of breast cancer cells. Int J Mol Sci. 18(E1863)2017.PubMed/NCBI View Article : Google Scholar

48 

Fleming NI, Jorissen RN, Mouradov D, Christie M, Sakthianandeswaren A, Palmieri M, Day F, Li S, Tsui C, Lipton L, et al: SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer. Cancer Res. 73:725–735. 2013.PubMed/NCBI View Article : Google Scholar

49 

Cheng JC, Chang HM and Leung PCK: TGF-β1 inhibits human trophoblast cell invasion by upregulating connective tissue growth factor expression. Endocrinology. 158:3620–3628. 2017.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zheng W, Chen A, Yang H and Hong L: MicroRNA‑27a inhibits trophoblast cell migration and invasion by targeting SMAD2: Potential role in preeclampsia. Exp Ther Med 20: 2262-2269, 2020.
APA
Zheng, W., Chen, A., Yang, H., & Hong, L. (2020). MicroRNA‑27a inhibits trophoblast cell migration and invasion by targeting SMAD2: Potential role in preeclampsia. Experimental and Therapeutic Medicine, 20, 2262-2269. https://doi.org/10.3892/etm.2020.8924
MLA
Zheng, W., Chen, A., Yang, H., Hong, L."MicroRNA‑27a inhibits trophoblast cell migration and invasion by targeting SMAD2: Potential role in preeclampsia". Experimental and Therapeutic Medicine 20.3 (2020): 2262-2269.
Chicago
Zheng, W., Chen, A., Yang, H., Hong, L."MicroRNA‑27a inhibits trophoblast cell migration and invasion by targeting SMAD2: Potential role in preeclampsia". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2262-2269. https://doi.org/10.3892/etm.2020.8924
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng W, Chen A, Yang H and Hong L: MicroRNA‑27a inhibits trophoblast cell migration and invasion by targeting SMAD2: Potential role in preeclampsia. Exp Ther Med 20: 2262-2269, 2020.
APA
Zheng, W., Chen, A., Yang, H., & Hong, L. (2020). MicroRNA‑27a inhibits trophoblast cell migration and invasion by targeting SMAD2: Potential role in preeclampsia. Experimental and Therapeutic Medicine, 20, 2262-2269. https://doi.org/10.3892/etm.2020.8924
MLA
Zheng, W., Chen, A., Yang, H., Hong, L."MicroRNA‑27a inhibits trophoblast cell migration and invasion by targeting SMAD2: Potential role in preeclampsia". Experimental and Therapeutic Medicine 20.3 (2020): 2262-2269.
Chicago
Zheng, W., Chen, A., Yang, H., Hong, L."MicroRNA‑27a inhibits trophoblast cell migration and invasion by targeting SMAD2: Potential role in preeclampsia". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2262-2269. https://doi.org/10.3892/etm.2020.8924
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team