Open Access

Correlation between asthmatic infants with rickets and vitamin D, inflammatory factors and immunoglobulin E

  • Authors:
    • Aibibai Aierken
    • Bweimaieryemu Yusufu
    • Peiru Xu
  • View Affiliations

  • Published online on: June 26, 2020     https://doi.org/10.3892/etm.2020.8949
  • Pages: 2122-2126
  • Copyright: © Aierken et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Correlation between asthmatic infants with rickets and vitamin D, inflammatory factors and immunoglobulin was investigated. A total of 60 child patients with asthma who met the inclusion criteria and received treatment from January 2016 to October 2017 were collected. Among them, 17 asthmatic infants with rickets were set as observation group, while 43 child patients with simple asthma were regarded as the control group. Venous blood was drawn from the two groups of subjects after admission. The levels of interleukin‑1 (IL‑1), IL‑6 and IL‑17 in serum were determined by ELISA, vitamin D and immunoglobulin E levels in serum were detected using a fully‑automatic biochemical analyzer, and wheezing duration during asthma attack was recorded. IL‑1, IL‑6, IL‑17 and immunoglobulin E levels in serum of observation group were significantly higher than those of the control group (P<0.05). The vitamin D level in the observation group was remarkably lower than that in the control group (P<0.05). Wheezing duration in observation group was evidently longer than that in control group (P<0.05). Moreover, IL‑1, IL‑6, IL‑17 and immunoglobulin E levels in serum were positively related to wheezing duration, but the vitamin D level was negatively associated with wheezing duration. Infantile asthma with rickets is closely correlated with vitamin D, inflammatory factors and immunoglobulin E, which are major risk factors in infantile asthma with rickets.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Aierken A, Yusufu B and Xu P: Correlation between asthmatic infants with rickets and vitamin D, inflammatory factors and immunoglobulin E. Exp Ther Med 20: 2122-2126, 2020
APA
Aierken, A., Yusufu, B., & Xu, P. (2020). Correlation between asthmatic infants with rickets and vitamin D, inflammatory factors and immunoglobulin E. Experimental and Therapeutic Medicine, 20, 2122-2126. https://doi.org/10.3892/etm.2020.8949
MLA
Aierken, A., Yusufu, B., Xu, P."Correlation between asthmatic infants with rickets and vitamin D, inflammatory factors and immunoglobulin E". Experimental and Therapeutic Medicine 20.3 (2020): 2122-2126.
Chicago
Aierken, A., Yusufu, B., Xu, P."Correlation between asthmatic infants with rickets and vitamin D, inflammatory factors and immunoglobulin E". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2122-2126. https://doi.org/10.3892/etm.2020.8949