Open Access

Relationship between chemokines and T lymphocytes in the context of respiratory allergies (Review)

  • Authors:
    • Nicolae Ovidiu Berghi
    • Mihai Dumitru
    • Daniela Vrinceanu
    • Radu Constantin Ciuluvica
    • Anca Simioniuc-Petrescu
    • Ramona Caragheorgheopol
    • Catalin Tucureanu
    • Roxana Sfrent Cornateanu
    • Calin Giurcaneanu
  • View Affiliations

  • Published online on: June 29, 2020     https://doi.org/10.3892/etm.2020.8961
  • Pages: 2352-2360
  • Copyright: © Berghi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Allergic diseases have been classified in the last decades using various theories. The main classes of the newest classification in allergic respiratory diseases focus on the characterization of the endotype (which takes into account biomarkers related to determinant pathophysiological mechanisms) and of the phenotype (based on the description of the disease). Th2, Th1 and Th17 lymphocytes and the type of inflammatory response mediated by them represent the basis for Th2 and non‑Th2 endotype classification. In addition, new lymphocytes were also used to characterize allergic diseases: Th9 lymphocytes, Th22 lymphocytes, T follicular helper cells (TFh) lymphocytes and invariant natural killer T (iNKT) lymphocytes. In the last decade, a growing body of evidence focused on chemokines, chemoattractant cytokines, which seems to have an important contribution to the pathogenesis of this pathology. This review presents the interactions between chemokines and Th lymphocytes in the context of Th2/non‑Th2 endotype classification of respiratory allergies.
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September-2020
Volume 20 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Berghi NO, Dumitru M, Vrinceanu D, Ciuluvica RC, Simioniuc-Petrescu A, Caragheorgheopol R, Tucureanu C, Cornateanu RS and Giurcaneanu C: Relationship between chemokines and T lymphocytes in the context of respiratory allergies (Review). Exp Ther Med 20: 2352-2360, 2020
APA
Berghi, N.O., Dumitru, M., Vrinceanu, D., Ciuluvica, R.C., Simioniuc-Petrescu, A., Caragheorgheopol, R. ... Giurcaneanu, C. (2020). Relationship between chemokines and T lymphocytes in the context of respiratory allergies (Review). Experimental and Therapeutic Medicine, 20, 2352-2360. https://doi.org/10.3892/etm.2020.8961
MLA
Berghi, N. O., Dumitru, M., Vrinceanu, D., Ciuluvica, R. C., Simioniuc-Petrescu, A., Caragheorgheopol, R., Tucureanu, C., Cornateanu, R. S., Giurcaneanu, C."Relationship between chemokines and T lymphocytes in the context of respiratory allergies (Review)". Experimental and Therapeutic Medicine 20.3 (2020): 2352-2360.
Chicago
Berghi, N. O., Dumitru, M., Vrinceanu, D., Ciuluvica, R. C., Simioniuc-Petrescu, A., Caragheorgheopol, R., Tucureanu, C., Cornateanu, R. S., Giurcaneanu, C."Relationship between chemokines and T lymphocytes in the context of respiratory allergies (Review)". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2352-2360. https://doi.org/10.3892/etm.2020.8961