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Review Open Access

Genetics of schizophrenia (Review)

  • Authors:
    • Simona Corina Trifu
    • Bianca Kohn
    • Andrei Vlasie
    • Bogdan-Eduard Patrichi
  • View Affiliations / Copyright

    Affiliations: Department of Neurosciences, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Psychiatry, ‘Prof. Dr. Alexandru Obregia’ Clinical Hospital of Psychiatry, 041914 Bucharest, Romania, Department of Psychiatry and Psychology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
    Copyright: © Trifu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3462-3468
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    Published online on: July 7, 2020
       https://doi.org/10.3892/etm.2020.8973
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Abstract

A comprehensive review of the body of genetic studies on schizophrenia seems even more daunting than the battle a psychiatrist wages daily in the office with her archenemy of a thousand faces. The following article reunites some genetic, epigenetic and environmental factors of schizophrenia from revered and vast studies in a chronological and progressive fashion. Twin studies set the basics of heritability and a particular study by Davis and Phelps considers the widely ignored influence of prenatal environment in the development of schizophrenia. Mostly ignited by linkage studies, candidate gene studies explore further by fine‑mapping the hypothesized variants [mostly in the forms single nucleotide polymorphisms (SNPs) and less but with greater impact copy number variations (CNVs)] associated with the disease. Genome‑wide association studies (GWAS) increase considerably the sample sizes and thus the validity of the results, while the next‑generation sequencing (NGS) attain the highest yet unreplicated level of validity results.
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Copy and paste a formatted citation
Spandidos Publications style
Trifu SC, Kohn B, Vlasie A and Patrichi B: Genetics of schizophrenia (Review). Exp Ther Med 20: 3462-3468, 2020.
APA
Trifu, S.C., Kohn, B., Vlasie, A., & Patrichi, B. (2020). Genetics of schizophrenia (Review). Experimental and Therapeutic Medicine, 20, 3462-3468. https://doi.org/10.3892/etm.2020.8973
MLA
Trifu, S. C., Kohn, B., Vlasie, A., Patrichi, B."Genetics of schizophrenia (Review)". Experimental and Therapeutic Medicine 20.4 (2020): 3462-3468.
Chicago
Trifu, S. C., Kohn, B., Vlasie, A., Patrichi, B."Genetics of schizophrenia (Review)". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3462-3468. https://doi.org/10.3892/etm.2020.8973
Copy and paste a formatted citation
x
Spandidos Publications style
Trifu SC, Kohn B, Vlasie A and Patrichi B: Genetics of schizophrenia (Review). Exp Ther Med 20: 3462-3468, 2020.
APA
Trifu, S.C., Kohn, B., Vlasie, A., & Patrichi, B. (2020). Genetics of schizophrenia (Review). Experimental and Therapeutic Medicine, 20, 3462-3468. https://doi.org/10.3892/etm.2020.8973
MLA
Trifu, S. C., Kohn, B., Vlasie, A., Patrichi, B."Genetics of schizophrenia (Review)". Experimental and Therapeutic Medicine 20.4 (2020): 3462-3468.
Chicago
Trifu, S. C., Kohn, B., Vlasie, A., Patrichi, B."Genetics of schizophrenia (Review)". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3462-3468. https://doi.org/10.3892/etm.2020.8973
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