Effect of perioperative amplitude‑integrated electroencephalography on neurodevelopmental outcomes following infant heart surgery

  • Authors:
    • Juan Gui
    • Suixin Liang
    • Yunxia Sun
    • Yumei Liu
    • Chen Chen
    • Bi Wang
    • Jing Zhong
    • Yuhui Yu
    • Shaoru He
  • View Affiliations

  • Published online on: July 13, 2020     https://doi.org/10.3892/etm.2020.9004
  • Pages: 2879-2887
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Abstract

The purpose of the current study was to determine the effect of perioperative amplitude‑integrated electroencephalography (aEEG) on neurodevelopmental outcomes in infants with congenital heart disease (CHD). A total of 93 children with CHD were included in the current study. All patients enrolled in the present study had undergone cardiac surgery prior to 3 months of age and pre‑ or postoperative aEEG was monitored. Participants were assessed after 1 year using the Bayley Scales of Infant Test. A total of 82.2% of infants exhibited continuous normal voltage preoperatively (CNV) and 93.7% exhibited CNV postoperatively. Seizures were indicated in 2 infants preoperatively and 3 infants postoperatively. Compared with infants with PDI, infants with cyanotic CHD (β=17.218) exhibited a significantly lower MDI, an increased length of intensive care stay, and lower PDI scores (β=‑0.577). Infants that underwent surgery with CPB exhibited higher PDI scores (β=11.956). Infants that exhibited behavioral problems also had lower PDI scores (β=‑10.605). An abnormal preoperative background pattern and an absent postoperative SWC independently predicted poorer motor (P=0.014) and cognitive (P=0.049) outcomes at 1 year. The current study demonstrated that infants with CHD who underwent cardiac surgery prior to 3 months of age exhibited delayed neurodevelopmental outcomes, and that an aEEG assessment can aid in predicting these outcomes following surgery.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Gui J, Liang S, Sun Y, Liu Y, Chen C, Wang B, Zhong J, Yu Y and He S: Effect of perioperative amplitude‑integrated electroencephalography on neurodevelopmental outcomes following infant heart surgery. Exp Ther Med 20: 2879-2887, 2020
APA
Gui, J., Liang, S., Sun, Y., Liu, Y., Chen, C., Wang, B. ... He, S. (2020). Effect of perioperative amplitude‑integrated electroencephalography on neurodevelopmental outcomes following infant heart surgery. Experimental and Therapeutic Medicine, 20, 2879-2887. https://doi.org/10.3892/etm.2020.9004
MLA
Gui, J., Liang, S., Sun, Y., Liu, Y., Chen, C., Wang, B., Zhong, J., Yu, Y., He, S."Effect of perioperative amplitude‑integrated electroencephalography on neurodevelopmental outcomes following infant heart surgery". Experimental and Therapeutic Medicine 20.3 (2020): 2879-2887.
Chicago
Gui, J., Liang, S., Sun, Y., Liu, Y., Chen, C., Wang, B., Zhong, J., Yu, Y., He, S."Effect of perioperative amplitude‑integrated electroencephalography on neurodevelopmental outcomes following infant heart surgery". Experimental and Therapeutic Medicine 20, no. 3 (2020): 2879-2887. https://doi.org/10.3892/etm.2020.9004