Influence of phytochemicals in induced psoriasis (Review)

  • Authors:
    • Elena Niculet
    • Diana Sabina Radaschin
    • Florentina Nastase
    • Miruna Draganescu
    • Liliana Baroiu
    • Magdalena Miulescu
    • Manuela Arbune
    • Alin Laurentiu Tatu
  • View Affiliations

  • Published online on: July 14, 2020     https://doi.org/10.3892/etm.2020.9013
  • Pages: 3421-3424
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Abstract

Cytokines involved in pathogenesis of psoriasis such as interleukins (IL‑1β, IL‑6, IL‑17, IL‑22, IL‑23), interferon‑α, tumor necrosis factor‑α and interferon‑γ can also become therapeutic targets. Research currently uses murine models of imiquimod‑induced psoriatic‑type dermatitis in order to analyze potentially helpful phytotherapeutics for psoriasis treatment: Curcuma longa, Aloe vera, Nigella sativa, Rubia cordifolia, Smilax china, Thespesia populnea, Wrightia tinctoria, Scutellaria baicalensis, Cassia tora, Pongamia pinnata and various Chinese herbal formulas. Psoriasis is a chronic inflammatory disease with complex pathogenic mechanisms that yield abnormal immune responses with clinical and morphological echoes (erythematous, scaly plaques with a histopathological basis made up of alterations i.e. keratinocyte aberrant proliferation, parakeratosis or chronic inflammation). The current therapeutic approach has only been able to manage the disease, without ensuring a certified treatment, thus giving rise to the need for better medications. This novel therapeutic approach has shown promising results in preclinical studies, giving hope for future phytochemical animal‑based studies.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Niculet E, Radaschin DS, Nastase F, Draganescu M, Baroiu L, Miulescu M, Arbune M and Tatu AL: Influence of phytochemicals in induced psoriasis (Review). Exp Ther Med 20: 3421-3424, 2020
APA
Niculet, E., Radaschin, D.S., Nastase, F., Draganescu, M., Baroiu, L., Miulescu, M. ... Tatu, A.L. (2020). Influence of phytochemicals in induced psoriasis (Review). Experimental and Therapeutic Medicine, 20, 3421-3424. https://doi.org/10.3892/etm.2020.9013
MLA
Niculet, E., Radaschin, D. S., Nastase, F., Draganescu, M., Baroiu, L., Miulescu, M., Arbune, M., Tatu, A. L."Influence of phytochemicals in induced psoriasis (Review)". Experimental and Therapeutic Medicine 20.4 (2020): 3421-3424.
Chicago
Niculet, E., Radaschin, D. S., Nastase, F., Draganescu, M., Baroiu, L., Miulescu, M., Arbune, M., Tatu, A. L."Influence of phytochemicals in induced psoriasis (Review)". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3421-3424. https://doi.org/10.3892/etm.2020.9013