Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2020 Volume 20 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2020 Volume 20 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Dormant cardiac stem cells: A promising tool in cardiac regeneration

  • Authors:
    • Zenaida Ceausu
    • Bogdan Socea
    • Mihai C.T. Dimitriu
    • Dragoş Predescu
    • Vlad D. Constantin
    • Nicolae Bacalbaşa
    • Cătălin Cîrstoveanu
    • Mariana Costache
    • Mihai Ceausu
  • View Affiliations / Copyright

    Affiliations: Pathology Department, ‘Sf. Pantelimon’ Emergency Clinical Hospital, 021659 Bucharest, Romania, Department of Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Pediatrics Department, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Pathology Department, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
    Copyright: © Ceausu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3452-3457
    |
    Published online on: July 15, 2020
       https://doi.org/10.3892/etm.2020.9015
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Stem cells represent an old niche with various new potential therapeutics. Besides drug treatment, reperfusion procedures and surgical revascularization, stem cell therapy could be a good option in ischemic cardiac diseases. A study was performed on a small group of cases who died of cardiac arrhythmia secondary to scarring myocardial infarctions. Tissue cardiac samples were taken from these cases (from the anterior and lateral wall of the left ventricle), for microscopy examination, in order to investigate the presence of cardiac stem cells (CSC). Multiple series of histological sections were also performed and examined, along with immunohistochemical analysis (IHC). The cells were identified in close contact with the residual ischemic cardiomyocytes, in the proximity of the myocardial collagenous scar, in old myocardial infarctions. They were activated by hypoxic ischemia and were influenced by the capillary microvascular density and the interstitial micro‑environment conditions. In chronic intermittent ischemia they seem to turn themselves from dormant quiescent cells into activated progenitor committed cells.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Manea M, Marcu D, Pantea Stoian A, Gaman MA, Gaman AM, Socea B, Neagu TP, Stanescu AMA, Bratu OG and Diaconu CC: Heart failure with preserved ejection fraction and atrial fibrillation: A review. Rev Chim. 69:4180–4184. 2018.

2 

Abela GS, Kalavakunta JK, Janoudi A, Leffler D, Dhar G, Salehi N, Cohn J, Shah I, Karve M, Kotaru VPK, et al: Frequency of cholesterol crystals in culprit coronary artery aspirate during acute myocardial infarction and their relation to inflammation and myocardial injury. Am J Cardiol. 120:1699–1707. 2017.PubMed/NCBI View Article : Google Scholar

3 

Diaconu C: Midaortic syndrome in a young man: Case presentation. Cor Vasa. 59:e171–e173. 2017.

4 

Tica OA, Tica O, Antal L, Hatos A, Popescu MI, Pantea Stoian A, Bratu OG, Gaman MA, Pituru SM and Diaconu CC: Modern oral anticoagulant treatment in patients with atrial fibrillation and heart failure: Insights from the clinical practice. Farmacia. 66:972–976. 2018.

5 

Laslo C, Pantea Stoian A, Socea B, Paduraru D, Bodean O, Socea L, Neagu TP, Stanescu AMA, Marcu D and Diaconu C: New oral anticoagulants and their reversal agents. J Mind Med Sci. 5:195–201. 2018.

6 

Rebouças JS, Santos-Magalhães NS and Formiga FR: Cardiac regeneration using growth factors: Advances and challenges. Arq Bras Cardiol. 107:271–275. 2016.PubMed/NCBI View Article : Google Scholar

7 

Prasad M, Corban MT, Henry TD, Dietz AB, Lerman LO and Lerman A: Promise of autologous CD34+ stem/progenitor cell therapy for treatment of cardiovascular disease. Cardiovasc Res: Feb 5, 2020 (Epub ahead of print). doi: 10.1093/cvr/cvaa027.

8 

Nadal-Ginard B, Kajstura J, Leri A and Anversa P: Myocyte death, growth, and regeneration in cardiac hypertrophy and failure. Circ Res. 92:139–150. 2003.PubMed/NCBI View Article : Google Scholar

9 

Dixit P and Katare R: Challenges in identifying the best source of stem cells for cardiac regeneration therapy. Stem Cell Res Ther. 6(26)2015.PubMed/NCBI View Article : Google Scholar

10 

Tateishi K, Ashihara E, Honsho S, Takehara N, Nomura T, Takahashi T, Ueyama T, Yamagishi M, Yaku H, Matsubara H, et al: Human cardiac stem cells exhibit mesenchymal features and are maintained through Akt/GSK-3beta signaling. Biochem Biophys Res Commun. 352:635–641. 2007.PubMed/NCBI View Article : Google Scholar

11 

Chong JJ, Reinecke H, Iwata M, Torok-Storb B, Stempien-Otero A and Murry CE: Progenitor cells identified by PDGFR-alpha expression in the developing and diseased human heart. Stem Cells Dev. 22:1932–1943. 2013.PubMed/NCBI View Article : Google Scholar

12 

Lee H, Douglas-Jones AG, Morgan JM and Jasani B: The effect of fixation and processing on the sensitivity of oestrogen receptor assay by immunohistochemistry in breast carcinoma. J Clin Pathol. 55:236–238. 2002.PubMed/NCBI View Article : Google Scholar

13 

Tan DW and Barker N: Intestinal stem cells and their defining niche. Curr Top Dev Biol. 107:77–107. 2014.PubMed/NCBI View Article : Google Scholar

14 

Latil M, Rocheteau P, Châtre L, Sanulli S, Mémet S, Ricchetti M, Tajbakhsh S and Chrétien F: Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity. Nat Commun. 3(903)2012.PubMed/NCBI View Article : Google Scholar

15 

Ceausu M, Hostiuc S and Dermengiu D: Skeletal muscle satellite stem cells at different postmortem intervals. Rev Med Leg. 24:23–27. 2016.

16 

Popescu LM, Curici A, Wang E, Zhang H, Hu S and Gherghiceanu M: Telocytes and putative stem cells in ageing human heart. J Cell Mol Med. 19:31–45. 2015.PubMed/NCBI View Article : Google Scholar

17 

Bettencourt-Dias M, Mittnacht S and Brockes JP: Heterogeneous proliferative potential in regenerative adult newt cardiomyocytes. J Cell Sci. 116:4001–4009. 2003.PubMed/NCBI View Article : Google Scholar

18 

Jopling C, Sleep E, Raya M, Marti M, Raya A and Belmonte JC: Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature. 464:606–609. 2010.PubMed/NCBI View Article : Google Scholar

19 

Rasmussen TL, Raveendran G, Zhang J and Garry DJ: Getting to the heart of myocardial stem cells and cell therapy. Circulation. 123:1771–1779. 2011.PubMed/NCBI View Article : Google Scholar

20 

Anversa P, Kajstura J, Leri A and Bolli R: Life and death of cardiac stem cells: A paradigm shift in cardiac biology. Circulation. 113:1451–1463. 2006.PubMed/NCBI View Article : Google Scholar

21 

Messina E, De Angelis L, Frati G, Morrone S, Chimenti S, Fiordaliso F, Salio M, Battaglia M, Latronico MV, Coletta M, et al: Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res. 95:911–921. 2004.PubMed/NCBI View Article : Google Scholar

22 

Smith RR, Barile L, Cho HC, Leppo MK, Hare JM, Messina E, Giacomello A, Abraham MR and Marbán E: Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation. 115:896–908. 2007.PubMed/NCBI View Article : Google Scholar

23 

Urbanek K, Rota M, Cascapera S, Bearzi C, Nascimbene A, De Angelis A, Hosoda T, Chimenti S, Baker M, Limana F, et al: Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ Res. 97:663–673. 2005.PubMed/NCBI View Article : Google Scholar

24 

Docshin PM, Karpov AA, Eyvazova SD, Puzanov MV, Kostareva AA, Galagudza MM and Malashicheva AB: Activation of cardiac stem cells in myocardial infarction. Cell Tissue Biol. 12:175–182. 2018.

25 

Constantin VD, Socea B, Popa F, Carâp AC, Popescu G, Vlădescu T, Ceauşu Z, Berteşteanu ŞV and Ceauşu MC: A histopathological and immunohistochemical approach of surgical emergencies of GIST. An interdisciplinary study. Rom J Morphol Embryol. 55 (Suppl):619–627. 2014.PubMed/NCBI

26 

Zeng B, Ren XF, Cao F, Zhou XY and Zhang J: Developmental patterns and characteristics of epicardial cell markers Tbx18 and Wt1 in murine embryonic heart. J Biomed Sci. 18(67)2011.PubMed/NCBI View Article : Google Scholar

27 

Sussman MA: Cardiac nonmyocyte subpopulations: A secular congregation. Regen Med. 14:489–494. 2019.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ceausu Z, Socea B, Dimitriu MC, Predescu D, Constantin VD, Bacalbaşa N, Cîrstoveanu C, Costache M and Ceausu M: Dormant cardiac stem cells: A promising tool in cardiac regeneration. Exp Ther Med 20: 3452-3457, 2020.
APA
Ceausu, Z., Socea, B., Dimitriu, M.C., Predescu, D., Constantin, V.D., Bacalbaşa, N. ... Ceausu, M. (2020). Dormant cardiac stem cells: A promising tool in cardiac regeneration. Experimental and Therapeutic Medicine, 20, 3452-3457. https://doi.org/10.3892/etm.2020.9015
MLA
Ceausu, Z., Socea, B., Dimitriu, M. C., Predescu, D., Constantin, V. D., Bacalbaşa, N., Cîrstoveanu, C., Costache, M., Ceausu, M."Dormant cardiac stem cells: A promising tool in cardiac regeneration". Experimental and Therapeutic Medicine 20.4 (2020): 3452-3457.
Chicago
Ceausu, Z., Socea, B., Dimitriu, M. C., Predescu, D., Constantin, V. D., Bacalbaşa, N., Cîrstoveanu, C., Costache, M., Ceausu, M."Dormant cardiac stem cells: A promising tool in cardiac regeneration". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3452-3457. https://doi.org/10.3892/etm.2020.9015
Copy and paste a formatted citation
x
Spandidos Publications style
Ceausu Z, Socea B, Dimitriu MC, Predescu D, Constantin VD, Bacalbaşa N, Cîrstoveanu C, Costache M and Ceausu M: Dormant cardiac stem cells: A promising tool in cardiac regeneration. Exp Ther Med 20: 3452-3457, 2020.
APA
Ceausu, Z., Socea, B., Dimitriu, M.C., Predescu, D., Constantin, V.D., Bacalbaşa, N. ... Ceausu, M. (2020). Dormant cardiac stem cells: A promising tool in cardiac regeneration. Experimental and Therapeutic Medicine, 20, 3452-3457. https://doi.org/10.3892/etm.2020.9015
MLA
Ceausu, Z., Socea, B., Dimitriu, M. C., Predescu, D., Constantin, V. D., Bacalbaşa, N., Cîrstoveanu, C., Costache, M., Ceausu, M."Dormant cardiac stem cells: A promising tool in cardiac regeneration". Experimental and Therapeutic Medicine 20.4 (2020): 3452-3457.
Chicago
Ceausu, Z., Socea, B., Dimitriu, M. C., Predescu, D., Constantin, V. D., Bacalbaşa, N., Cîrstoveanu, C., Costache, M., Ceausu, M."Dormant cardiac stem cells: A promising tool in cardiac regeneration". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3452-3457. https://doi.org/10.3892/etm.2020.9015
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team