Dormant cardiac stem cells: A promising tool in cardiac regeneration

Ceausu,Zenaida; Socea,Bogdan; Dimitriu,Mihai   C.T.; Predescu,Dragoş; Constantin,Vlad   D.; Bacalbaşa,Nicolae; Cîrstoveanu,Cătălin; Costache,Mariana; Ceausu,Mihai

doi:10.3892/etm.2020.9015

Dormant cardiac stem cells: A promising tool in cardiac regeneration

Authors:
- Zenaida Ceausu
- Bogdan Socea
- Mihai C.T. Dimitriu
- Dragoş Predescu
- Vlad D. Constantin
- Nicolae Bacalbaşa
- Cătălin Cîrstoveanu
- Mariana Costache
- Mihai Ceausu
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Affiliations: Pathology Department, ‘Sf. Pantelimon’ Emergency Clinical Hospital, 021659 Bucharest, Romania, Department of Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Pediatrics Department, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Pathology Department, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
Published online on: July 15, 2020 https://doi.org/10.3892/etm.2020.9015
Pages: 3452-3457
Copyright: © Ceausu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Stem cells represent an old niche with various new potential therapeutics. Besides drug treatment, reperfusion procedures and surgical revascularization, stem cell therapy could be a good option in ischemic cardiac diseases. A study was performed on a small group of cases who died of cardiac arrhythmia secondary to scarring myocardial infarctions. Tissue cardiac samples were taken from these cases (from the anterior and lateral wall of the left ventricle), for microscopy examination, in order to investigate the presence of cardiac stem cells (CSC). Multiple series of histological sections were also performed and examined, along with immunohistochemical analysis (IHC). The cells were identified in close contact with the residual ischemic cardiomyocytes, in the proximity of the myocardial collagenous scar, in old myocardial infarctions. They were activated by hypoxic ischemia and were influenced by the capillary microvascular density and the interstitial micro‑environment conditions. In chronic intermittent ischemia they seem to turn themselves from dormant quiescent cells into activated progenitor committed cells.

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