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Astilbin-induced inhibition of the PI3K/AKT signaling pathway decelerates the progression of osteoarthritis

  • Authors:
    • Chunlin Chen
    • Mao Yang
    • Yujiang Chen
    • Yaoyao Wang
    • Kun Wang
    • Tengxian Li
    • Qing Hu
    • Wenjing Zhang
    • Jingfu Xia
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550001, P.R. China, Miao Medicine Department, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550001, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3078-3083
    |
    Published online on: July 27, 2020
       https://doi.org/10.3892/etm.2020.9048
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Abstract

Degeneration and destruction of articular cartilage are the key characteristics of osteoarthritis (OA). In recent studies, the use of astilbin (AST), the primary active ingredient of Astilbe chinensis, has been shown to correlate with a reduction in inflammatory disease symptoms. The present study aimed to investigate the effects and mechanisms of AST on OA. A rat model of OA was constructed and in vivo experiments were performed using the AST, PBS, OA and control groups. The cartilage tissues of each group were assessed by hematoxylin and eosin and toluidine blue staining. The gene expression levels of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-6, AKT, PI3K and other related proteins were analyzed by reverse transcription-quantitative PCR and western blot analysis. AST was found to significantly inhibit IL-1β and TNF-α protein expression; this further confirmed that IL-1β, TNF-α and PI3K mRNA expression was downregulated, indicating that the protective mechanism of AST is associated with the PI3K/AKT pathway. Overall, the results of the present study demonstrate that AST can improve OA symptoms by downregulating the PI3K/AKT signaling pathway, and may therefore be a potential therapeutic option for patients with OA.
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1 

Thielen NGM, van der Kraan PM and van Caam APM: TGFβ/BMP signaling pathway in cartilage homeostasis. Cells. 8(E969)2019.PubMed/NCBI View Article : Google Scholar

2 

Neogi T: Structural correlates of pain in osteoarthritis. Clin Exp Rheumatol. 35 (Suppl 107):75–78. 2017.PubMed/NCBI

3 

Zhao Y, Li Z, Wang W, Zhang H, Chen J, Su P, Liu L and Li W: Naringin protects against cartilage destruction in osteoarthritis through repression of NF-κB signaling pathway. Inflammation. 39:385–392. 2016.PubMed/NCBI View Article : Google Scholar

4 

Ahn H, La JH, Chung JM, Miao H, Zhong C, Kim M, An K, Lyon D, Choi E and Fillingim RB: The relationship between β-endorphin and experimental pain sensitivity in older adults with knee osteoarthritis. Biol Res Nurs. 21:400–406. 2019.PubMed/NCBI View Article : Google Scholar

5 

Mehana EE, Khafaga AF and El-Blehi SS: The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review. Life Sci. 234(116786)2019.PubMed/NCBI View Article : Google Scholar

6 

Fei J, Liang B, Jiang C, Ni H and Wang L: Luteolin inhibits IL-1β-induced inflammation in rat chondrocytes and attenuates osteoarthritis progression in a rat model. Biomed Pharmacother. 109:1586–1592. 2019.PubMed/NCBI View Article : Google Scholar

7 

He X, Yi T, Tang Y, Xu J, Zhang J, Zhang Y, Dong L and Chen H: Assessing the quality of Smilacis Glabrae Rhizoma (Tufuling) by colormetrics and UPLC-Q-TOF-MS. Chin Med. 11(33)2016.PubMed/NCBI View Article : Google Scholar

8 

Hao G, Zheng J, Huo R, Li J, Wen K, Zhang Y and Liang G: Smilax glabra Roxb targets Aktp-Thr308 and inhibits Akt-mediated signaling pathways in SGC7901 cells. J Drug Target. 24:557–565. 2016.PubMed/NCBI View Article : Google Scholar

9 

Dong L, Zhu J, Du H, Nong H, He X and Chen X: Astilbin from Smilax glabra Roxb. Attenuates inflammatory responses in complete Freund's adjuvant-induced arthritis rats. Evid Based Complement Alternat Med. 2017(8246420)2017.PubMed/NCBI View Article : Google Scholar

10 

Huang X, Xi Y, Mao Z, Chu X, Zhang R, Ma X, Ni B, Cheng H and You H: Vanillic acid attenuates cartilage degeneration by regulating the MAPK and PI3K/AKT/NF-κB pathways. Eur J Pharmacol. 859(172481)2019.PubMed/NCBI View Article : Google Scholar

11 

Lu CL, Zhu W, Wang M, Xu XJ and Lu CJ: Antioxidant and anti-inflammatory activities of phenolic-enriched extracts of Smilax glabra. Evid Based Complement Alternat Med. 2014(910438)2014.PubMed/NCBI View Article : Google Scholar

12 

Bijlsma JW, Berenbaum F and Lafeber FP: Osteoarthritis: An update with relevance for clinical practice. Lancet. 377:2115–2126. 2011.PubMed/NCBI View Article : Google Scholar

13 

Nguyen PT and Marquis RE: Antimicrobial actions of α-mangostin against oral streptococci. Can J Microbiol. 57:217–225. 2011.PubMed/NCBI View Article : Google Scholar

14 

Wang M, Yang XB, Zhao JW, Lu CJ and Zhu W: Structural characterization and macrophage immunomodulatory activity of a novel polysaccharide from Smilax glabra Roxb. Carbohydr Polym. 156:390–402. 2017.PubMed/NCBI View Article : Google Scholar

15 

Lu CL, Zhu YF, Hu MM, Wang DM, Xu XJ, Lu CJ and Zhu W: Optimization of astilbin extraction from the rhizome of Smilax glabra, and evaluation of its anti-inflammatory effect and probable underlying mechanism in lipopolysaccharide-induced RAW264.7 macrophages. Molecules. 20:625–644. 2015.PubMed/NCBI View Article : Google Scholar

16 

Yan R and Xu Q: Astilbin selectively facilitates the apoptosis of interleukin-2-dependent phytohemagglutinin-activated Jurkat cells. Pharmacol Res. 44:135–139. 2001.PubMed/NCBI View Article : Google Scholar

17 

Cai Y, Chen T and Xu Q: Astilbin suppresses collagen-induced arthritis via the dysfunction of lymphocytes. Inflamm Res. 52:334–340. 2003.PubMed/NCBI View Article : Google Scholar

18 

Fei M, Wu X and Xu Q: Astilbin inhibits contact hypersensitivity through negative cytokine regulation distinct from cyclosporin A. J Allergy Clin Immunol. 116:1350–1356. 2005.PubMed/NCBI View Article : Google Scholar

19 

Guo L, Liu W, Lu T, Guo W, Gao J, Luo Q, Wu X, Sun Y, Wu X, Shen Y, et al: Decrease of functional activated T and B cells and treatment of glomerulonephitis in lupus-prone mice using a natural flavonoid astilbin. PLoS One. 10(e0124002)2015.PubMed/NCBI View Article : Google Scholar

20 

Kaneko S, Satoh T, Chiba J, Ju C, Inoue K and Kagawa J: Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis. Cytokines Cell Mol Ther. 6:71–79. 2000.PubMed/NCBI View Article : Google Scholar

21 

Szekanecz Z and Koch AE: Successes and failures of chemokine-pathway targeting in rheumatoid arthritis. Nat Rev Rheumatol. 12:5–13. 2016.PubMed/NCBI View Article : Google Scholar

22 

Guha M and Mackman N: LPS induction of gene expression in human monocytes. Cell Signal. 13:85–94. 2001.PubMed/NCBI View Article : Google Scholar

23 

Mateen S, Zafar A, Moin S, Khan AQ and Zubair S: Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis. Clin Chim Acta. 455:161–171. 2016.PubMed/NCBI View Article : Google Scholar

24 

Chen J, Crawford R and Xiao Y: Vertical inhibition of the PI3K/Akt/mTOR pathway for the treatment of osteoarthritis. J Cell Biochem. 114:245–249. 2013.PubMed/NCBI View Article : Google Scholar

25 

Yuan FL, Xu RS, Jiang DL, He XL, Su Q, Jin C and Li X: Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-κB and PI3K/Akt signaling pathways. Bone. 75:128–137. 2015.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Chen C, Yang M, Chen Y, Wang Y, Wang K, Li T, Hu Q, Zhang W and Xia J: Astilbin-induced inhibition of the PI3K/AKT signaling pathway decelerates the progression of osteoarthritis. Exp Ther Med 20: 3078-3083, 2020.
APA
Chen, C., Yang, M., Chen, Y., Wang, Y., Wang, K., Li, T. ... Xia, J. (2020). Astilbin-induced inhibition of the PI3K/AKT signaling pathway decelerates the progression of osteoarthritis. Experimental and Therapeutic Medicine, 20, 3078-3083. https://doi.org/10.3892/etm.2020.9048
MLA
Chen, C., Yang, M., Chen, Y., Wang, Y., Wang, K., Li, T., Hu, Q., Zhang, W., Xia, J."Astilbin-induced inhibition of the PI3K/AKT signaling pathway decelerates the progression of osteoarthritis". Experimental and Therapeutic Medicine 20.4 (2020): 3078-3083.
Chicago
Chen, C., Yang, M., Chen, Y., Wang, Y., Wang, K., Li, T., Hu, Q., Zhang, W., Xia, J."Astilbin-induced inhibition of the PI3K/AKT signaling pathway decelerates the progression of osteoarthritis". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3078-3083. https://doi.org/10.3892/etm.2020.9048
Copy and paste a formatted citation
x
Spandidos Publications style
Chen C, Yang M, Chen Y, Wang Y, Wang K, Li T, Hu Q, Zhang W and Xia J: Astilbin-induced inhibition of the PI3K/AKT signaling pathway decelerates the progression of osteoarthritis. Exp Ther Med 20: 3078-3083, 2020.
APA
Chen, C., Yang, M., Chen, Y., Wang, Y., Wang, K., Li, T. ... Xia, J. (2020). Astilbin-induced inhibition of the PI3K/AKT signaling pathway decelerates the progression of osteoarthritis. Experimental and Therapeutic Medicine, 20, 3078-3083. https://doi.org/10.3892/etm.2020.9048
MLA
Chen, C., Yang, M., Chen, Y., Wang, Y., Wang, K., Li, T., Hu, Q., Zhang, W., Xia, J."Astilbin-induced inhibition of the PI3K/AKT signaling pathway decelerates the progression of osteoarthritis". Experimental and Therapeutic Medicine 20.4 (2020): 3078-3083.
Chicago
Chen, C., Yang, M., Chen, Y., Wang, Y., Wang, K., Li, T., Hu, Q., Zhang, W., Xia, J."Astilbin-induced inhibition of the PI3K/AKT signaling pathway decelerates the progression of osteoarthritis". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3078-3083. https://doi.org/10.3892/etm.2020.9048
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