Expression of miR‑409‑5p in gestational diabetes mellitus and its relationship with insulin resistance

  • Authors:
    • Chuanfa Tu
    • Lijun Wang
    • Haiying Tao
    • Lingjia Gu
    • Shuang Zhu
    • Xiaolu Chen
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  • Published online on: July 27, 2020     https://doi.org/10.3892/etm.2020.9049
  • Pages: 3324-3329
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Abstract

Expression of miR-409-5p in gestational diabetes mellitus (GDM) and its relationship with insulin resistance were explore. One hundred and forty‑nine pregnant women who underwent antenatal examination in Taizhou First People's Hospital were divided into a GDM group and a control group according to whether they had GDM or not. Serum miR‑409‑5p expression of the two groups was detected, and the levels of glycosylated hemoglobin (HbAlc) and other GDM‑related biochemical indicators were measured. Fasting plasma glucose (FPG) was determined by glucose oxidase method, fasting insulin (FINS) was detected by radioimmunoassay, and homeostasis model assessment of insulin resistance (HOMA‑IR) was calculated. The relationship between miR‑409‑5p and other biochemical indicators and insulin resistance was analyzed, and logistic multivariate regression was employed to analyze the risk factors of GDM. miR‑409‑5p was highly expressed in the serum of GDM patients. HbAlc, FPG, FINS, and HOMA‑IR in pregnant women in the GDM group were markedly higher than those in the control group. The serum miR‑409‑5p in GDM pregnant women showed a positive correlation with HbAlc, FPG, FINS, and HOMA‑IR (P<0.05). The insulin resistance group presented remarkably higher serum miR‑409‑5p level than the non‑insulin resistance group. Moreover, it was found that elevated miR‑409‑5p, FINS, and HOMA‑IR were all independent risk factors for the onset of GDM. miR‑409‑5p is highly expressed in the serum of patients with GDM, and it is positively correlated with insulin resistance index of GDM patients, which may be a potential target for clinical diagnosis and treatment of GDM.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Tu C, Wang L, Tao H, Gu L, Zhu S and Chen X: Expression of miR‑409‑5p in gestational diabetes mellitus and its relationship with insulin resistance. Exp Ther Med 20: 3324-3329, 2020
APA
Tu, C., Wang, L., Tao, H., Gu, L., Zhu, S., & Chen, X. (2020). Expression of miR‑409‑5p in gestational diabetes mellitus and its relationship with insulin resistance. Experimental and Therapeutic Medicine, 20, 3324-3329. https://doi.org/10.3892/etm.2020.9049
MLA
Tu, C., Wang, L., Tao, H., Gu, L., Zhu, S., Chen, X."Expression of miR‑409‑5p in gestational diabetes mellitus and its relationship with insulin resistance". Experimental and Therapeutic Medicine 20.4 (2020): 3324-3329.
Chicago
Tu, C., Wang, L., Tao, H., Gu, L., Zhu, S., Chen, X."Expression of miR‑409‑5p in gestational diabetes mellitus and its relationship with insulin resistance". Experimental and Therapeutic Medicine 20, no. 4 (2020): 3324-3329. https://doi.org/10.3892/etm.2020.9049