Open Access

Cardiac CT scanning in coronary artery disease: Epicardial fat volume and its correlation with coronary artery lesions and left ventricular function

  • Authors:
    • Ruohan Yin
    • Xiaoqiang Tang
    • Tao Wang
    • Haifeng Shi
    • Xiang Wang
    • Xiaoqin Wang
    • Changjie Pan
  • View Affiliations

  • Published online on: July 28, 2020     https://doi.org/10.3892/etm.2020.9064
  • Pages: 2961-2968
  • Copyright: © Yin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Coronary artery disease (CAD) is a major and common disease that poses a threat to human health. Recent studies suggested that epicardial fat may have an important role in the pathogenesis of CAD. Therefore, the association between epicardial fat volume (EFV) and left ventricular function with CAD was investigated in the present study. A total of 61 patients with suspected CAD who underwent CT scanning were enrolled. Baseline data, parameters of left heart function and EFV of the subjects were collected and analyzed. The degree of coronary artery lesions was assessed using the Gensini score. Pearson's correlation analysis and a logistic regression model were applied to assess the association between EFV and risk factors for CAD, the Gensini score and left ventricular function index. A total of 29 female and 32 male subjects with a median age of 63 years were enrolled. The median body mass index (BMI) of the subjects was 23.37 kg/m2 and the median EFV was 86.41 cm3. It was revealed that risk factors of CAD, specially hypertension, diabetes mellitus, dyslipidemia, history of myocardial infarction and smoking, had no significant association with the EFV (P>0.05); however, the EFV was significantly positively correlated with the BMI (r=0.479, P<0.0001), interventricular septal thickness (r=0.436, P=0.004), left ventricular posterior wall thickness (r=0.350, P=0.0058), left ventricular end diastolic diameter (r=0.265, P=0.0388), left ventricular mass (r=0.445, P=0.0003) and left ventricular mass index (r=0.371, P=0.0035). However, no correlation was identified between the EFV and the Gensini score (r=0.131, P=0.3137). In conclusion, the EFV measured by cardiac CT scanning was positively correlated with the BMI and left ventricular function, but was not associated with the presence of CAD according to the Gensini scores.
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October-2020
Volume 20 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yin R, Tang X, Wang T, Shi H, Wang X, Wang X and Pan C: Cardiac CT scanning in coronary artery disease: Epicardial fat volume and its correlation with coronary artery lesions and left ventricular function. Exp Ther Med 20: 2961-2968, 2020
APA
Yin, R., Tang, X., Wang, T., Shi, H., Wang, X., Wang, X., & Pan, C. (2020). Cardiac CT scanning in coronary artery disease: Epicardial fat volume and its correlation with coronary artery lesions and left ventricular function. Experimental and Therapeutic Medicine, 20, 2961-2968. https://doi.org/10.3892/etm.2020.9064
MLA
Yin, R., Tang, X., Wang, T., Shi, H., Wang, X., Wang, X., Pan, C."Cardiac CT scanning in coronary artery disease: Epicardial fat volume and its correlation with coronary artery lesions and left ventricular function". Experimental and Therapeutic Medicine 20.4 (2020): 2961-2968.
Chicago
Yin, R., Tang, X., Wang, T., Shi, H., Wang, X., Wang, X., Pan, C."Cardiac CT scanning in coronary artery disease: Epicardial fat volume and its correlation with coronary artery lesions and left ventricular function". Experimental and Therapeutic Medicine 20, no. 4 (2020): 2961-2968. https://doi.org/10.3892/etm.2020.9064