Experimental induction of blunt chest trauma in mice: A modified approach with evaluation in dummies and cadavers

Höfer,Denis; Körbel,Christina; Laschke,Matthias W.; Veith,Nils T.; Pohlemann,Tim; Kappl,Reinhard; Tschernig,Thomas

doi:10.3892/etm.2020.9156

November-2020 Volume 20 Issue 5

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November-2020 Volume 20 Issue 5

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Experimental induction of blunt chest trauma in mice: A modified approach with evaluation in dummies and cadavers

Authors:
- Denis Höfer
- Christina Körbel
- Matthias W. Laschke
- Nils T. Veith
- Tim Pohlemann
- Reinhard Kappl
- Thomas Tschernig
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Affiliations: Department of Anatomy and Cell Biology, Saarland University, D‑66421 Homburg/Saar, Germany, Department of Clinical and Experimental Surgery, Saarland University, D‑66421 Homburg/Saar, Germany, Department of Trauma, Hand and Reconstructive Surgery, Saarland University, D‑66421 Homburg/Saar, Germany, Department of Biophysics, Saarland University, D‑66421 Homburg/Saar, Germany

Copyright: © Höfer et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 28
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Published online on: August 31, 2020

https://doi.org/10.3892/etm.2020.9156
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Abstract

Experimental chest trauma or blunt thoracic trauma using a blast wave mechanism is well established in animal models. The aim of the present study was to establish a complementary, murine experimental chest trauma model precisely defined by physical data and calculations. For this purpose, a device was developed using a dropped weight and physical properties, including velocity, energy and impact, were calculated. The device allowed for the maximum depth of impression to be measured. The device was first tested using blocks of modelling clay and was then applied to mouse cadavers. X‑ray and dissection were performed to check for bone fractures and organ injuries following blunt chest traumas of increasing impact. Lesions and hemorrhages were observed in mouse cadavers which sustained a force equivalent to the energy of ~1 J.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Experimental induction of blunt chest trauma in mice: A modified approach with evaluation in dummies and cadavers

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