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Expression of Rab1A in bladder cancer and its clinical implications

  • Authors:
    • Hongwei Su
    • Ting Li
    • Chen Li
    • Xin Liu
    • Haibin Ling
    • Xiangdong Li
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075061, P.R. China, Department of Drug and Equipment, The Second Hospital of Zhangjiakou City, Zhangjiakou, Hebei 075061, P.R. China
    Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 44
    |
    Published online on: September 3, 2020
       https://doi.org/10.3892/etm.2020.9174
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Abstract

Rab1A protein has been identified to be highly expressed in a number of malignant tumor tissues and to participate in the regulation of tumor development, but no data concerning bladder cancer have been described at present. The present study measured the expression of Rab1A in bladder cancer tissues and cell lines, and analyzed its clinical significance for patients with bladder cancer. A total of 153 pairs of bladder cancer tumor tissues and adjacent cancer healthy tissues were included in the present study. Western blot analysis and immunohistochemistry were used to measure the expression of Rab1A protein in normal bladder and bladder cancer cell line, and bladder cancer and normal adjacent tissues. SPSS 20.0 software was used for statistical analysis and mapping of survival curves in patients with bladder cancer. The expression levels of Rab1A protein in normal bladder cells and tissues was significantly decreased compared with that in bladder cancer cells and tissues, and it was significantly associated with tumor size, histological grade, tumor‑node‑metastasis (TNM) stage, lymph node metastasis and remote metastasis in 153 patients with bladder cancer. Cox regression analysis demonstrated that the expression of Rab1A protein in bladder cancer tissues was an independent risk factor for prognosis (overall risk=0.549; 95% confidence interval=0.139‑0.916). The 5‑year survival rate of patients with bladder cancer with high expression levels of Rab1A protein was 48.613%, which was significantly decreased compared with the rate of patients with low expression 75.31% (P<0.05). The expression of Rab1A in bladder cancer tissues and cell lines was upregulated, and its expression increased with increasing TNM stages. It was also associated with the metastasis of tumor cells and negatively affected the survival time of patients with bladder cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Su H, Li T, Li C, Liu X, Ling H and Li X: Expression of Rab1A in bladder cancer and its clinical implications. Exp Ther Med 20: 44, 2020.
APA
Su, H., Li, T., Li, C., Liu, X., Ling, H., & Li, X. (2020). Expression of Rab1A in bladder cancer and its clinical implications. Experimental and Therapeutic Medicine, 20, 44. https://doi.org/10.3892/etm.2020.9174
MLA
Su, H., Li, T., Li, C., Liu, X., Ling, H., Li, X."Expression of Rab1A in bladder cancer and its clinical implications". Experimental and Therapeutic Medicine 20.5 (2020): 44.
Chicago
Su, H., Li, T., Li, C., Liu, X., Ling, H., Li, X."Expression of Rab1A in bladder cancer and its clinical implications". Experimental and Therapeutic Medicine 20, no. 5 (2020): 44. https://doi.org/10.3892/etm.2020.9174
Copy and paste a formatted citation
x
Spandidos Publications style
Su H, Li T, Li C, Liu X, Ling H and Li X: Expression of Rab1A in bladder cancer and its clinical implications. Exp Ther Med 20: 44, 2020.
APA
Su, H., Li, T., Li, C., Liu, X., Ling, H., & Li, X. (2020). Expression of Rab1A in bladder cancer and its clinical implications. Experimental and Therapeutic Medicine, 20, 44. https://doi.org/10.3892/etm.2020.9174
MLA
Su, H., Li, T., Li, C., Liu, X., Ling, H., Li, X."Expression of Rab1A in bladder cancer and its clinical implications". Experimental and Therapeutic Medicine 20.5 (2020): 44.
Chicago
Su, H., Li, T., Li, C., Liu, X., Ling, H., Li, X."Expression of Rab1A in bladder cancer and its clinical implications". Experimental and Therapeutic Medicine 20, no. 5 (2020): 44. https://doi.org/10.3892/etm.2020.9174
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