Correlation of TNF‑&alpha; and IL‑10 gene polymorphisms with primary nephrotic syndrome

Xiao,Min; Bai,Shoujun; Chen,Jing; Xie,Lijun; Li,Yaxi; Li,Yongning; Zhang,Shu; Wu,Yifan; Tan,Gongjun; Wang,Wenlian; Wang,Yu; Quan,Li; Hu,Zhao

doi:10.3892/etm.2020.9215

November-2020 Volume 20 Issue 5

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November-2020 Volume 20 Issue 5

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Article

Correlation of TNF‑α and IL‑10 gene polymorphisms with primary nephrotic syndrome

Authors:
- Min Xiao
- Shoujun Bai
- Jing Chen
- Lijun Xie
- Yaxi Li
- Yongning Li
- Shu Zhang
- Yifan Wu
- Gongjun Tan
- Wenlian Wang
- Yu Wang
- Li Quan
- Zhao Hu
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Affiliations: Department of Nephrology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Nephrology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai 201700, P.R. China, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China, Fujian Provincial Key Laboratory of Screening for Novel Microbial Products, Fujian Institute of Microbiology, Fuzhou, Fujian 350007, P.R. China, Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA, Department of Pharmacy, Fujian Health College, Fuzhou, Fujian 352121, P.R. China, Center for Infectious and Inflammatory Diseases, Texas A&M Health Science Center, Houston, TX 77030, USA, Department of Clinical Laboratory, Zhuhai People's Hospital, Zhuhai, Guangdong 519000, P.R. China, Key Laboratory of Instrument Science and Dynamic Measurement, Ministry of Education, North University of China, Taiyuan, Shanxi 038507, P.R. China, Department of Mechanical and Material Engineering, Huaiyin Institute of Technology, Huai'an, Jiangsu 223003, P.R. China
Article Number: 87
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Published online on: September 11, 2020

https://doi.org/10.3892/etm.2020.9215
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Abstract

The study explored the correlations of tumor necrosis factor‑α (TNF‑α) and interleukin‑1β (IL‑1β) gene polymorphisms with susceptibility and the condition of primary nephrotic syndrome. A total of 200 patients with primary nephrotic syndrome in Qilu hospital were collected as disease group, and 200 healthy people were selected as control group. Genomic deoxyribonucleic acids (DNAs) of nucleated cells in the peripheral blood were extracted to detect the gene polymorphisms of TNF‑α (rs1799724 and rs1800629) and IL‑10 (rs1800872 and rs141219090). Allele distributions at rs1799724 (P=0.003) and rs1800629 (P=0.011) of TNF‑α gene and at rs1800872 (P=0.033) of IL‑10 gene in disease group were different from those in control group. In the disease group, allele C frequency at rs1799724 and allele A frequency at rs1800629 of TNF‑α gene and allele T frequency at rs1800872 of IL‑10 gene were higher. There were differences between rs1799724 (P=0.007) and rs1800629 (P=0.002) of TNF‑α gene. In addition, there was a difference in the frequency of the dominant model of TNF‑α gene rs1800629 between disease group and control group (P=0.035), and the frequency of dominant model GG+GA was remarkably lower in the disease group. Additionally, TT genotype at rs1799724 of TNF‑α gene was obviously related to the plasma TNF‑α level (P<0.05), and the plasma TNF‑α level was significantly increased in disease group. AA genotype at rs141219090 of IL‑10 gene had a notable correlation with the plasma IL‑10 level (P<0.05), and the plasma IL‑10 level in disease group was markedly raised. Additionally, CT genotype at rs1799724 of TNF‑α gene was related to the 24‑h urine protein level (P=0.035), GG genotype at rs1800872 of IL‑10 gene was associated with the plasma albumin level (P=0.031), and GG genotype at rs141219090 was related to the serum creatinine level (P=0.047). TNF‑α and IL‑10 gene polymorphisms are predominantly correlated with the susceptibility and the condition of primary nephrotic syndrome.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Correlation of TNF‑α and IL‑10 gene polymorphisms with primary nephrotic syndrome

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