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SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway

  • Authors:
    • Quan Du
    • Juan Chen
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    Affiliations: Department of Urology, Xianyang Central Hospital, Xianyang, Shaanxi 712000, P.R. China, Department of Urology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China
    Copyright: © Du et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 110
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    Published online on: September 18, 2020
       https://doi.org/10.3892/etm.2020.9238
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Abstract

Long non‑coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) has been previously reported to mediate a number of functions during the progression of cancer. However, its involvement in bladder cancer remain unclear. The aim of the present study was to investigate the expression of SNHG1 in bladder cancer and to identify its potential mechanisms. SNHG1 expression was firstly detected in cancer tissues and cells. The effects of SNHG1 on the malignant phenotypes were then investigated. Furthermore, the influence of SNHG1 on the PI3K/AKT signaling pathway was examined. It was demonstrated that SNHG1 expression was significantly upregulated in bladder cancer tissues and cells. Moreover, the loss‑of‑function experimental results suggested that knockdown of SNHG1 inhibited bladder cancer cell proliferation, migration and invasion, but increased apoptosis; however, SNHG1 overexpression promoted these processes. Mechanistically, rescue assays identified that SNHG1 activated the PI3K/AKT signaling pathway. Therefore, it was speculated that SNHG1 functioned as a carcinogenic lncRNA in bladder cancer via activation of PI3K/AKT.
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Copy and paste a formatted citation
Spandidos Publications style
Du Q and Chen J: SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway. Exp Ther Med 20: 110, 2020.
APA
Du, Q., & Chen, J. (2020). SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway. Experimental and Therapeutic Medicine, 20, 110. https://doi.org/10.3892/etm.2020.9238
MLA
Du, Q., Chen, J."SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway". Experimental and Therapeutic Medicine 20.5 (2020): 110.
Chicago
Du, Q., Chen, J."SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway". Experimental and Therapeutic Medicine 20, no. 5 (2020): 110. https://doi.org/10.3892/etm.2020.9238
Copy and paste a formatted citation
x
Spandidos Publications style
Du Q and Chen J: SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway. Exp Ther Med 20: 110, 2020.
APA
Du, Q., & Chen, J. (2020). SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway. Experimental and Therapeutic Medicine, 20, 110. https://doi.org/10.3892/etm.2020.9238
MLA
Du, Q., Chen, J."SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway". Experimental and Therapeutic Medicine 20.5 (2020): 110.
Chicago
Du, Q., Chen, J."SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway". Experimental and Therapeutic Medicine 20, no. 5 (2020): 110. https://doi.org/10.3892/etm.2020.9238
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