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Association between α1‑antitrypsin and acute coronary syndrome

  • Authors:
    • Yan Liu
    • Da Huang
    • Beilin Li
    • Wenjing Liu
    • Suren R. Sooranna
    • Xingshou Pan
    • Zhaohe Huang
    • Jun Guo
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China, Department of Cardiology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, UK
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 119
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    Published online on: September 21, 2020
       https://doi.org/10.3892/etm.2020.9247
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Abstract

α1‑antitrypsin (AAT) is a protein released as part of the anti‑inflammatory response. It regulates the activity of serine proteinases and has a crucial role in the pathogenesis of acute coronary syndrome (ACS). The present study aimed to examine its role in patients with ACS. The plasma samples of 117 patients were collected at the Cardiology Department of the Affiliated Hospital of Youjiang Medical University (Baise, China). These included 46 cases of ACS (who met the diagnostic criteria for ACS and had ≥50% luminal stenosis of any coronary vessel), 35 cases of stable angina (SA; with ≥50% luminal stenosis of any coronary vessel but in a stable condition) and 36 normal healthy controls (subjects with no luminal stenosis in their coronary arteries). Plasma AAT protein concentrations were measured by ELISA and clinical data were collected. The plasma levels of AAT protein in patients with ACS were lower than those in controls and cases of SA (P<0.05), and the levels tended to decrease with the number of coronary artery lesions involved. There were no significant associations of the expression of plasma AAT protein and the number of diseased vessels in patients or the degree of stenosis. There was no correlation between the plasma protein levels of AAT and Gensini scores of patients with ACS. In conclusion, the plasma AAT protein levels in patients with ACS may contribute to the occurrence and development of coronary artery disease.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Huang D, Li B, Liu W, Sooranna SR, Pan X, Huang Z and Guo J: Association between &alpha;1‑antitrypsin and acute coronary syndrome. Exp Ther Med 20: 119, 2020.
APA
Liu, Y., Huang, D., Li, B., Liu, W., Sooranna, S.R., Pan, X. ... Guo, J. (2020). Association between &alpha;1‑antitrypsin and acute coronary syndrome. Experimental and Therapeutic Medicine, 20, 119. https://doi.org/10.3892/etm.2020.9247
MLA
Liu, Y., Huang, D., Li, B., Liu, W., Sooranna, S. R., Pan, X., Huang, Z., Guo, J."Association between &alpha;1‑antitrypsin and acute coronary syndrome". Experimental and Therapeutic Medicine 20.5 (2020): 119.
Chicago
Liu, Y., Huang, D., Li, B., Liu, W., Sooranna, S. R., Pan, X., Huang, Z., Guo, J."Association between &alpha;1‑antitrypsin and acute coronary syndrome". Experimental and Therapeutic Medicine 20, no. 5 (2020): 119. https://doi.org/10.3892/etm.2020.9247
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Huang D, Li B, Liu W, Sooranna SR, Pan X, Huang Z and Guo J: Association between &alpha;1‑antitrypsin and acute coronary syndrome. Exp Ther Med 20: 119, 2020.
APA
Liu, Y., Huang, D., Li, B., Liu, W., Sooranna, S.R., Pan, X. ... Guo, J. (2020). Association between &alpha;1‑antitrypsin and acute coronary syndrome. Experimental and Therapeutic Medicine, 20, 119. https://doi.org/10.3892/etm.2020.9247
MLA
Liu, Y., Huang, D., Li, B., Liu, W., Sooranna, S. R., Pan, X., Huang, Z., Guo, J."Association between &alpha;1‑antitrypsin and acute coronary syndrome". Experimental and Therapeutic Medicine 20.5 (2020): 119.
Chicago
Liu, Y., Huang, D., Li, B., Liu, W., Sooranna, S. R., Pan, X., Huang, Z., Guo, J."Association between &alpha;1‑antitrypsin and acute coronary syndrome". Experimental and Therapeutic Medicine 20, no. 5 (2020): 119. https://doi.org/10.3892/etm.2020.9247
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