lncRNA‑MALAT1 expression in patients with coronary atherosclerosis and its predictive value for in‑stent restenosis

Qiu,Shi; Sun,Jinhui

doi:10.3892/etm.2020.9258

lncRNA‑MALAT1 expression in patients with coronary atherosclerosis and its predictive value for in‑stent restenosis

Authors:
- Shi Qiu
- Jinhui Sun
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Affiliations: Department of Cardiovascular Surgery, The Second Hospital of Shandong University, Jinan, Shandong 250000, P.R. China
Published online on: October 1, 2020 https://doi.org/10.3892/etm.2020.9258
Article Number: 129

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Abstract

This study was designed to investigate the long non‑coding RNA (lncRNA)‑metastasis associated lung adenocarcinoma transcript 1 (MALAT1) expression in patients with coronary atherosclerosis and its predictive value for in‑stent restenosis. Ninety‑five patients with coronary heart disease who came to our hospital for treatment and underwent stent implantation were selected as a research group (RG), and 95 volunteers undergoing physical examination who did not suffer from coronary heart disease during the same period were selected as a control group (CG). MALAT1 of subjects in both groups before and after treatment were detected by RT‑qPCR, and N‑terminal pro‑brain natriuretic peptide (NT‑proBNP), high sensitivity C‑reactive protein (hs‑CRP), lactate dehydrogenase (LDH), and creatine kinase isoenzyme (CK‑MB) of them in the RG before treatment were detected. The level was evaluated and detected, and its correlation with MALAT1 was analyzed. Then, the predictive value of MALAT1 for in‑stent restenosis in patients with coronary heart disease was analyzed. MALAT1 expression in patients with coronary heart disease was higher than that of normal subjects (P<0.05); after treatment, the expression levels of MALAT1, NT‑proBNP, hs‑CRP, LDH, and CK‑MB in the serum of patients were significantly lower than those before treatment (P<0.05); MALAT1 expression was positively correlated with the expression levels of NT‑proBNP, hs‑CRP, LDH, and CK‑MB (P<0.05). Receiver operating characteristic of MALAT1 for predicting in‑stent restenosis in patients with coronary heart disease was over 0.8; the number of lesions, MALAT1, diabetes, NT‑proBNP and hs‑CRP were independent risk factors for in‑stent restenosis. MALAT1 is highly expressed in the serum of patients with coronary heart disease, and it has high value in its diagnosis and the prediction of in‑stent restenosis. It is also an independent risk factor for in‑stent restenosis in patients with coronary heart disease.

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