Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2020 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2020 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Expression and predictive value of HIF‑1α and VEGF in patients with burns following treatment

  • Authors:
    • Zhufeng Liu
    • Ling Liu
    • Xuejuan Cheng
    • Liming Gao
  • View Affiliations / Copyright

    Affiliations: Department of Burn Dermatology, Jinan City People's Hospital, Jinan, Shandong 271100, P.R. China, Department of Nursing, The People's Hospital of Zouping City, Binzhou, Shandong 256200, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 141
    |
    Published online on: October 5, 2020
       https://doi.org/10.3892/etm.2020.9270
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to investigate the expression and predictive value of serum hypoxia‑inducible factor‑1α (HIF‑1α) and vascular endothelial growth factor (VEGF) in patients with burns following treatment. A total of 84 patients with burns treated in Jinan City People's Hospital (Jinan, China) between June 2015 and August 2017 were selected and their clinical information was collected. The expression levels of HIF‑1α and VEGF before and after treatment were detected via ELISA, and HIF‑1α and VEGF levels in patients with effective and ineffective treatment were compared. The predictive values of HIF‑1α and VEGF in clinical efficacy were determined using receiver operating characteristic (ROC) curves, and independent risk factors affecting treatment inefficacy were analyzed via multivariate logistic regression. It was revealed that HIF‑1α decreased significantly (P<0.05) while VEGF significantly increased in patients after treatment. Patients with effective treatment presented significantly lower HIF‑1α levels and higher VEGF levels compared with those with ineffective treatment. The ROC curve indicated that the area under the curve (AUC) of HIF‑1α for treatment efficacy was 0.795, the 95% CI was 0.666‑0.924, the specificity and sensitivity were 68.75 and 80.88%, respectively, and the Youden index was 49.63%. For VEGF, the AUC, 95% CI, specificity, sensitivity and Youden index were 0.826, 0.725‑0.928, 68.75, 82.35 and 51.10% respectively. Moreover, under the joint detection of HIF‑1α and VEGF, the AUC was 0.847, 95% CI was 0.746‑0.947, specificity and sensitivity were 87.50 and 66.18%, respectively, with a Youden index of 53.68%. Multivariate analysis demonstrated that higher HIF‑1α level, lower VEGF level and higher burn degree before treatment were independent risk factors for treatment inefficacy. HIF‑1α levels decreased and VEGF levels increased in burn patients after treatment. HIF‑1α and VEGF before treatment may therefore serve as predictors for treatment efficacy.
View Figures

Figure 1

Figure 2

View References

1 

Rowan MP, Cancio LC, Elster EA, Burmeister DM, Rose LF, Natesan S, Chan RK, Christy RJ and Chung KK: Burn wound healing and treatment: Review and advancements. Crit Care. 19(243)2015.PubMed/NCBI View Article : Google Scholar

2 

Kraft R, Herndon DN, Finnerty CC, Cox RA, Song J and Jeschke MG: Predictive value of IL-8 for sepsis and severe infections after burn injury - A clinical. study. Shock. 43:222–227. 2015.PubMed/NCBI View Article : Google Scholar

3 

Clark A, Imran J, Madni T and Wolf SE: Nutrition and metabolism in burn patients. Burns Trauma. 5(11)2017.PubMed/NCBI View Article : Google Scholar

4 

Oryan A, Alemzadeh E and Moshiri A: Burn wound healing: Present concepts, treatment strategies and future. directions. J Wound Care. 26:5–19. 2017.PubMed/NCBI View Article : Google Scholar

5 

Hidalgo F, Mas D, Rubio M and Garcia-Hierro P: Infections in critically ill burn patients. Med Intensiva. 40:179–185. 2016.PubMed/NCBI View Article : Google Scholar

6 

Saaiq M, Ahmad S and Zaib MS: Burn wound infections and antibiotic susceptibility patterns at Pakistan institute of medical sciences, Islamabad, Pakistan. World J Plast Surg. 4:9–15. 2015.PubMed/NCBI

7 

Park SY, Lee SW, Kim HY, Lee WS, Hong KW and Kim CD: HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1α activation. Eur J Immunol. 45:1216–1227. 2015.PubMed/NCBI View Article : Google Scholar

8 

Kim Y, Nam HJ, Lee J, Park DY, Kim C, Yu YS, Kim D, Park SW, Bhin J, Hwang D, et al: Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis. Nat Commun. 7(10347)2016.PubMed/NCBI View Article : Google Scholar

9 

MacLauchlan SC, Calabro NE, Huang Y, Krishna M, Bancroft T, Sharma T, Yu J, Sessa WC, Giordano F and Kyriakides TR: HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2. Matrix Biol. 65:45–58. 2018.PubMed/NCBI View Article : Google Scholar

10 

Zhang X, Liu L, Wei X, Tan YS Tong L, Chang R, Ghanamah MS, Reinblatt M, Marti GP, Harmon JW and Semenza GL: Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF-1alpha heterozygous-null mice after burn wounding. Wound Repair Regen. 18:193–201. 2010.PubMed/NCBI View Article : Google Scholar

11 

Banyard DA, Adnani BO, Melkumyan S, Araniego CA and Widgerow AD: Endothelial progenitor cells and burn injury-exploring the relationship. Burns Trauma. 4(4)2016.PubMed/NCBI View Article : Google Scholar

12 

Rumney RMH, Tozzi G, Kao A, Lanham SA, Kanczler JM, Kao AP, Thiagarajan L, Dixon JE, Tozzi G and Oreffo ROC: In vivo delivery of VEGF RNA and protein to increase osteogenesis and intraosseous angiogenesis. Sci Rep. 9(17745)2019.PubMed/NCBI View Article : Google Scholar

13 

Feng Q, Zhang C, Lum D, Druso JE, Blank B, Wilson KF, Welm A, Antonyak MA and Cerione RA: A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis. Nat Commun. 8(14450)2017.PubMed/NCBI View Article : Google Scholar

14 

Morland C, Andersson KA, Haugen ØP, Hadzic A, Kleppa L, Gille A, Rinholm JE, Palibrk V, Diget EH, Kennedy LH, et al: Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. Nat Commun. 8(15557)2017.PubMed/NCBI View Article : Google Scholar

15 

Basagiannis D, Zografou S, Murphy C, Fotsis T, Morbidelli L, Ziche M, Bleck C, Mercer J and Christoforidis S: VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation through macropinocytosis. J Cell Sci. 129:4091–4104. 2016.PubMed/NCBI View Article : Google Scholar

16 

Grad S, Ertel W, Keel M, Infanger M, Vonderschmitt DJ and Maly FE: Strongly enhanced serum levels of vascular endothelial growth factor (VEGF) after poly-trauma and burn. Clin Chem Lab Med. 36:379–383. 1998.PubMed/NCBI View Article : Google Scholar

17 

Hwang C, Ucer S, Sorkin M, Loder S, Chung MT, Pagani C, Li J, Priest C, Breuler C, Vasquez K, et al: Identifying the role of and treatment targeting bone progenitor cell VEGF secretion on the niche supporting traumatic heterotopic ossification. Plast Reconstr Surg Glob Open. 6:21–22. 2018.

18 

Church D, Elsayed S, Reid O, Winston B and Lindsay R: Burn wound infections. Clin Microbiol Rev. 19:403–434. 2006.PubMed/NCBI View Article : Google Scholar

19 

Pagani A, Aitzetmüller MM, Brett EA, König V, Wenny R, Thor D, Radtke C, Huemer GM, Machens HG and Duscher D: Skin rejuvenation through HIF-1α modulation. Plast Reconstr Surg. 141:600e–607e. 2018.PubMed/NCBI View Article : Google Scholar

20 

Chen L, Zhong J, Li S, Li W, Wang B, Deng Y and Yuan J: The long-term effect of tacrolimus on alkali burn-induced corneal neovascularization and inflammation surpasses that of anti-vascular endothelial growth factor. Drug Des Devel Ther. 12:2959–2969. 2018.PubMed/NCBI View Article : Google Scholar

21 

Ciarlillo D, Celeste C, Carmeliet P, Boerboom D and Theoret C: A hypoxia response element in the Vegfa promoter is required for basal Vegfa expression in skin and for optimal granulation tissue formation during wound healing in mice. PLoS One. 12(e0180586)2017.PubMed/NCBI View Article : Google Scholar

22 

Lei R, Li J, Liu F, Li W, Zhang S, Wang Y, Chu X and Xu J: HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways. Cell Cycle. 18:3239–3250. 2019.PubMed/NCBI View Article : Google Scholar

23 

Qi H, Wang P, Liu C, Li M, Wang S, Huang Y and Wang F: Involvement of HIF-1α in MLCK-dependent endothelial barrier dysfunction in hypoxia. Cell Physiol Biochem. 27:251–262. 2011.PubMed/NCBI View Article : Google Scholar

24 

Tian KY, Liu XJ, Xu JD, Deng LJ and Wang G: Propofol inhibits burn injury-induced hyperpermeability through an apoptotic signal pathway in microvascular endothelial cells. Braz J Med Biol Res. 48:401–407. 2015.PubMed/NCBI View Article : Google Scholar

25 

Wu X, Li J, Yang X, Bai X, Shi J, Gao J, Li Y, Han S, Zhang Y, Han F, et al: miR-155 inhibits the formation of hypertrophic scar fibroblasts by targeting HIF-1α via PI3K/AKT pathway. J Mol Histol. 49:377–387. 2018.PubMed/NCBI View Article : Google Scholar

26 

Albina JE and Reichner JS: Oxygen and the regulation of gene expression in wounds. Wound Repair Regen. 11:445–451. 2003.PubMed/NCBI View Article : Google Scholar

27 

Haroon ZA, Raleigh JA, Greenberg CS and Dewhirst MW: Early wound healing exhibits cytokine surge without evidence of hypoxia. Ann Surg. 231:137–147. 2000.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Liu L, Cheng X and Gao L: Expression and predictive value of HIF‑1&alpha; and VEGF in patients with burns following treatment. Exp Ther Med 20: 141, 2020.
APA
Liu, Z., Liu, L., Cheng, X., & Gao, L. (2020). Expression and predictive value of HIF‑1&alpha; and VEGF in patients with burns following treatment. Experimental and Therapeutic Medicine, 20, 141. https://doi.org/10.3892/etm.2020.9270
MLA
Liu, Z., Liu, L., Cheng, X., Gao, L."Expression and predictive value of HIF‑1&alpha; and VEGF in patients with burns following treatment". Experimental and Therapeutic Medicine 20.6 (2020): 141.
Chicago
Liu, Z., Liu, L., Cheng, X., Gao, L."Expression and predictive value of HIF‑1&alpha; and VEGF in patients with burns following treatment". Experimental and Therapeutic Medicine 20, no. 6 (2020): 141. https://doi.org/10.3892/etm.2020.9270
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Liu L, Cheng X and Gao L: Expression and predictive value of HIF‑1&alpha; and VEGF in patients with burns following treatment. Exp Ther Med 20: 141, 2020.
APA
Liu, Z., Liu, L., Cheng, X., & Gao, L. (2020). Expression and predictive value of HIF‑1&alpha; and VEGF in patients with burns following treatment. Experimental and Therapeutic Medicine, 20, 141. https://doi.org/10.3892/etm.2020.9270
MLA
Liu, Z., Liu, L., Cheng, X., Gao, L."Expression and predictive value of HIF‑1&alpha; and VEGF in patients with burns following treatment". Experimental and Therapeutic Medicine 20.6 (2020): 141.
Chicago
Liu, Z., Liu, L., Cheng, X., Gao, L."Expression and predictive value of HIF‑1&alpha; and VEGF in patients with burns following treatment". Experimental and Therapeutic Medicine 20, no. 6 (2020): 141. https://doi.org/10.3892/etm.2020.9270
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team