Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2020 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2020 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

miR‑132 improves the cognitive function of rats with Alzheimer's disease by inhibiting the MAPK1 signal pathway

  • Authors:
    • Yiming Deng
    • Jingyu Zhang
    • Xuan Sun
    • Gaoting Ma
    • Gang Luo
    • Zhongrong Miao
    • Ligang Song
  • View Affiliations / Copyright

    Affiliations: Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, P.R. China
    Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 159
    |
    Published online on: October 7, 2020
       https://doi.org/10.3892/etm.2020.9288
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Alzheimer's disease (AD) is a common worldwide progressive neurodegenerative disease. The dysregulation of miRNA is crucial in neurodegenerative diseases and neuron apoptosis during AD and is closely associated with the MAPK pathway. By bioinformatic website, we found that there was target inhibiting relationship between microRNA (miR)‑132 and MAPK1. Therefore, the current study speculated that miR‑132 could improve the cognitive function of rats with AD by inhibiting MAPK1 expression. To verify our hypothesis, 10 normal rats and 60 rats with AD were selected and divided into model, Ad‑miR‑132 negative control (NC), Ad‑miR‑132, Ad‑small interfering (si)MAPK1 NC, Ad‑siMAPK1 and Ad‑miR‑132 + Ad‑MAPK1 groups. Rats were evaluated for learning by performing morris water maze tests and pathological changes of the hippocampus were assessed via HE staining. Additionally, hippocampus cell apoptosis was determined using a TUNEL assay and levels of acetylcholinesterase (AChE), reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH‑Px) were evaluated in sera via ELISA. The mRNA and protein expression of miR‑132, iNOS, MAPK1 and phosphorylated (p)‑MAPK1 was determined in hippocampus tissues via reverse transcription‑quantitative PCR and western blotting, respectively. Compared with normal mice, rats with AD had significantly decreased learning abilities, increased cell apoptosis rates, increased levels of AChE, iNOS, ROS, MDA, MAPK1 and p‑MAPK1 and decreased levels of SOD, GSH‑Px and miR‑132. Upregulation of miR‑132 group improved the above indictors and silencing MAKP1 worsened the condition of rats. miR‑132 upregulation therefore reversed the negative effects caused by MAPK1 silencing in rats with AD. In conclusion, miR‑132 inhibited hippocampal iNOS expression and oxidative stress by inhibiting MAPK1expression to improve the cognitive function of rats with AD.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Herrera-Espejo S, Santos-Zorrozua B, Álvarez-González P, Lopez-Lopez E and Garcia-Orad Á: A systematic review of microRNA expression as biomarker of late-onset Alzheimer's disease. Mol Neurobiol. 56:8376–8391. 2019.PubMed/NCBI View Article : Google Scholar

2 

Pan Y, Liu R, Terpstra E, Wang Y, Qiao F, Wang J, Tong Y and Pan B: Dysregulation and diagnostic potential of microRNA in Alzheimer's disease. J Alzheimers Dis. 49:1–12. 2016.PubMed/NCBI View Article : Google Scholar

3 

Ossenkoppele R, Mattsson N, Teunissen CE, Barkhof F, Pijnenburg Y, Scheltens P, van der Flier WM and Rabinovici GD: Cerebrospinal fluid biomarkers and cerebral atrophy in distinct clinical variants of probable Alzheimer's disease. Neurobiol Aging. 36:2340–2347. 2015.PubMed/NCBI View Article : Google Scholar

4 

Wu X, Cai H, Pan L, Cui G, Qin F, Li Y and Cai Z: Small molecule natural products and Alzheimer's disease. Curr Top Med Chem. 19:187–204. 2019.PubMed/NCBI View Article : Google Scholar

5 

Panza GA, Taylor BA, MacDonald HV, Johnson BT, Zaleski AL, Livingston J, Thompson PD and Pescatello LS: Can exercise improve cognitive symptoms of Alzheimer's disease? J Am Geriatr Soc. 66:487–495. 2018.PubMed/NCBI View Article : Google Scholar

6 

Torvinen-Kiiskinen S, Tolppanen AM, Koponen M, Tanskanen A, Tiihonen J, Hartikainen S and Taipale H: Proton pump inhibitor use and risk of hip fractures among community-dwelling persons with Alzheimer's disease-a nested case-control study. Aliment Pharmacol Ther. 47:1135–1142. 2018.PubMed/NCBI View Article : Google Scholar

7 

Nikolova G and Mancheva V: Analysis of the parameters of oxidative stress in patients with Parkinson's disease. Com Clin Pathol. 22:151–155. 2012.

8 

Bouchez C and Devin A: mitochondrial biogenesis and mitochondrial reactive oxygen species (ROS): A complex relationship regulated by the cAMP/PKA signaling pathway. Cells. 8(287)2019.PubMed/NCBI View Article : Google Scholar

9 

Gökçe Çokal B, Yurtdaş M, Keskin Güler S, Güneş HN, Ataç Uçar C, Aytaç B, Durak ZE, Yoldaş TK, Durak İ and Çubukçu HC: Serum glutathione peroxidase, xanthine oxidase, and superoxide dismutase activities and malondialdehyde levels in patients with Parkinson's disease. Neurol Sci. 38:425–431. 2017.PubMed/NCBI View Article : Google Scholar

10 

Jiang P, Li C, Xiang Z and Jiao B: Tanshinone IIA reduces the risk of Alzheimer's disease by inhibiting iNOS, MMP-2 and NF-κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer's disease. Mol Med Rep. 10:689–694. 2014.PubMed/NCBI View Article : Google Scholar

11 

Kumar S, Reddy AP, Yin X and Reddy PH: Novel MicroRNA-455-3p and its protective effects against abnormal APP processing and amyloid beta toxicity in Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis. 1865:2428–2440. 2019.PubMed/NCBI View Article : Google Scholar

12 

Davidson YS, Raby S, Foulds PG, Robinson A, Thompson JC, Sikkink S, Yusuf I, Amin H, DuPlessis D, Troakes C, et al: TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: Association with age, hippocampal sclerosis and clinical phenotype. Acta Neuropathol. 122:703–713. 2011.PubMed/NCBI View Article : Google Scholar

13 

Cruchaga C, Del-Aguila JL, Saef B, Black K, Fernandez MV, Budde J, Ibanez L, Deming Y, Kapoor M, Tosto G, et al: Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimers Dement. 14:205–214. 2018.PubMed/NCBI View Article : Google Scholar

14 

Jin SC, Pastor P, Cooper B, Cervantes S, Benitez BA, Razquin C and Goate A: Ibero-American Alzheimer Disease Genetics Group Researchers and Cruchaga C. Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort. Alzheimers Res Ther. 4(34)2012.PubMed/NCBI View Article : Google Scholar

15 

Duan Q and Si E: MicroRNA-25 aggravates Aβ1-42-induced hippocampal neuron injury in Alzheimer's disease by downregulating KLF2 via the Nrf2 signaling pathway in a mouse model. J Cell Biochem. 120:15891–15905. 2019.PubMed/NCBI View Article : Google Scholar

16 

Yang K, Feng S, Ren J and Zhou W: Upregulation of microRNA-196a improves cognitive impairment and alleviates neuronal damage in hippocampus tissues of Alzheimer's disease through downregulating LRIG3 expression. J Cell Biochem. 120:17811–17821. 2019.PubMed/NCBI View Article : Google Scholar

17 

Siedlecki-Wullich D, Català-Solsona J, Fábregas C, Hernández I, Clarimon J, Lleó A, Boada M, Saura CA, Rodríguez-Álvarez J and Miñano-Molina AJ: Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer's disease. Alzheimers Res Ther. 11(46)2019.PubMed/NCBI View Article : Google Scholar

18 

Luikart BW, Bensen AL, Washburn EK, Perederiy JV, Su KG, Li Y, Kernie SG, Parada LF and Westbrook GL: miR-132 mediates the integration of newborn neurons into the adult dentate gyrus. PLoS One. 6(e19077)2011.PubMed/NCBI View Article : Google Scholar

19 

Wang WX, Rajeev BW, Stromberg AJ, Ren N, Tang G, Huang Q, Rigoutsos I and Nelson PT: The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci. 28:1213–1223. 2008.PubMed/NCBI View Article : Google Scholar

20 

Jovicic A, Zaldivar Jolissaint JF, Moser R, Silva Santos Mde F and Luthi-Carter R: MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms. PLoS One. 8(e54222)2013.PubMed/NCBI View Article : Google Scholar

21 

Smith PY, Hernandez-Rapp J, Jolivette F, Lecours C, Bisht K, Goupil C, Dorval V, Parsi S, Morin F, Planel E, et al: miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo. Hum Mol Genet. 24:6721–6735. 2015.PubMed/NCBI View Article : Google Scholar

22 

Hansen KF, Sakamoto K, Aten S, Snider KH, Loeser J, Hesse AM, Page CE, Pelz C, Arthur JS, Impey S and Obrietan K: Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome. Learn Mem. 23:61–71. 2016.PubMed/NCBI View Article : Google Scholar

23 

Weinberg RB, Mufson EJ and Counts SE: Evidence for a neuroprotective microRNA pathway in amnestic mild cognitive impairment. Front Neurosci. 9(430)2015.PubMed/NCBI View Article : Google Scholar

24 

Li Y, Ba M, Du Y, Xia C, Tan S, Ng KP and Ma G: Aβ1-42 increases the expression of neural KATP subunits Kir6.2/SUR1 via the NF-κB, p38 MAPK and PKC signal pathways in rat primary cholinergic neurons. Hum Exp Toxicol. 38:665–674. 2019.PubMed/NCBI View Article : Google Scholar

25 

Jiang S, Zhao Y, Zhang T, Lan J, Yang J, Yuan L, Zhang Q, Pan K and Zhang K: Galantamine inhibits β-amyloid-induced cytostatic autophagy in PC12 cells through decreasing ROS production. Cell Prolif. 51(e12427)2018.PubMed/NCBI View Article : Google Scholar

26 

Meng M, Ai D, Sun L, Xu X and Cao X: EGb 761 inhibits Aβ1-42-induced neuroinflammatory response by suppressing P38 MAPK signaling pathway in BV-2 microglial cells. Neuroreport. 30:434–440. 2019.PubMed/NCBI View Article : Google Scholar

27 

Galoyan AA, Sarkissian JS, Chavushyan VA, Meliksetyan IB, Avagyan ZE, Poghosyan MV, Vahradyan HG, Mkrtchian HH and Abrahamyan DO: Neuroprotection by hypothalamic peptide proline-rich peptide-1 in Abeta25-35 model of Alzheimer's disease. Alzheimers Dement. 4:332–344. 2008.PubMed/NCBI View Article : Google Scholar

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

29 

Brennan S, Keon M, Liu B, Su Z and Saksena NK: Panoramic visualization of circulating microRNAs across neurodegenerative diseases in humans. Mol Neurobiol. 56:7380–7407. 2019.PubMed/NCBI View Article : Google Scholar

30 

Lin Y, Liang X, Yao Y, Xiao H, Shi Y and Yang J: Osthole attenuates APP-induced Alzheimer's disease through up-regulating miRNA-101a-3p. Life Sci. 225:117–131. 2019.PubMed/NCBI View Article : Google Scholar

31 

Gao S, Lin J, Wang T, Shen Y, Li Y, Yang W, Zhou K and Hu H: Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway. Drug Des Devel Ther. 13:459–475. 2019.PubMed/NCBI View Article : Google Scholar

32 

Sadlon A, Takousis P, Alexopoulos P, Evangelou E, Prokopenko I and Perneczky R: miRNAs identify shared pathways in Alzheimer's and Parkinson's diseases. Trends Mol Med. 25:662–672. 2019.PubMed/NCBI View Article : Google Scholar

33 

Prakash D and Sudhandiran G: Dietary flavonoid fisetin regulates aluminium chloride-induced neuronal apoptosis in cortex and hippocampus of mice brain. J Nutr Biochem. 26:1527–1539. 2015.PubMed/NCBI View Article : Google Scholar

34 

Che F, Du H, Zhang W, Cheng Z and Tong Y: MicroRNA-132 modifies angiogenesis in patients with ischemic cerebrovascular disease by suppressing the NF-κB and VEGF pathway. Mol Med Rep. 17:2724–2730. 2018.PubMed/NCBI View Article : Google Scholar

35 

Hwang S, Jeong H, Hong EH, Joo HM, Cho KS and Nam SY: Low-dose ionizing radiation alleviates Aβ42-induced cell death via regulating AKT and p38 pathways in Drosophila Alzheimer's disease models. Biol Open. 8(bio036657)2019.PubMed/NCBI View Article : Google Scholar

36 

Kim SJ, Hwang SG, Shin DY, Kang SS and Chun JS: p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation. J Biol Chem. 277:33501–33508. 2002.PubMed/NCBI View Article : Google Scholar

37 

Muraleva NA, Kolosova NG and Stefanova NA: p38 MAPK-dependent alphaB-crystallin phosphorylation in Alzheimer's disease-like pathology in OXYS rats. Exp Gerontol. 119:45–52. 2019.PubMed/NCBI View Article : Google Scholar

38 

Chen Y, Liang Z, Blanchard J, Dai CL, Sun S, Lee MH, Grundke-Iqbal I, Iqbal K, Liu F and Gong CX: A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: Similarities to and differences from the transgenic model (3xTg-AD mouse). Mol Neurobiol. 47:711–725. 2013.PubMed/NCBI View Article : Google Scholar

39 

Hu Z, Jiao R, Wang J, Wang P, Zhu Y, Zhao J, De Jager P, Bennett DA, Jin L and Xiong M: Shared causal paths underlying Alzheimer's dementia and type 2 diabetes. Sci Rep. 10(4107)2020.PubMed/NCBI View Article : Google Scholar

40 

Ishimoto T, Sugihara H, Watanabe M, Sawayama H, Iwatsuki M, Baba Y, Okabe H, Hidaka K, Yokoyama N, Miyake K, et al: Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation. Carcinogenesis. 35:1003–1011. 2014.PubMed/NCBI View Article : Google Scholar

41 

Ebi H, Sato T, Sugito N, Hosono Y, Yatabe Y, Matsuyama Y, Yamaguchi T, Osada H, Suzuki M and Takahashi T: Counterbalance between RB inactivation and miR-17-92 overexpression in reactive oxygen species and DNA damage induction in lung cancers. Oncogene. 28:3371–3379. 2009.PubMed/NCBI View Article : Google Scholar

42 

Taupin P: A dual activity of ROS and oxidative stress on adult neurogenesis and Alzheimer's disease. Cent Nerv Syst Agents Med Chem. 10:16–21. 2010.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Deng Y, Zhang J, Sun X, Ma G, Luo G, Miao Z and Song L: miR‑132 improves the cognitive function of rats with Alzheimer's disease by inhibiting the MAPK1 signal pathway. Exp Ther Med 20: 159, 2020.
APA
Deng, Y., Zhang, J., Sun, X., Ma, G., Luo, G., Miao, Z., & Song, L. (2020). miR‑132 improves the cognitive function of rats with Alzheimer's disease by inhibiting the MAPK1 signal pathway. Experimental and Therapeutic Medicine, 20, 159. https://doi.org/10.3892/etm.2020.9288
MLA
Deng, Y., Zhang, J., Sun, X., Ma, G., Luo, G., Miao, Z., Song, L."miR‑132 improves the cognitive function of rats with Alzheimer's disease by inhibiting the MAPK1 signal pathway". Experimental and Therapeutic Medicine 20.6 (2020): 159.
Chicago
Deng, Y., Zhang, J., Sun, X., Ma, G., Luo, G., Miao, Z., Song, L."miR‑132 improves the cognitive function of rats with Alzheimer's disease by inhibiting the MAPK1 signal pathway". Experimental and Therapeutic Medicine 20, no. 6 (2020): 159. https://doi.org/10.3892/etm.2020.9288
Copy and paste a formatted citation
x
Spandidos Publications style
Deng Y, Zhang J, Sun X, Ma G, Luo G, Miao Z and Song L: miR‑132 improves the cognitive function of rats with Alzheimer's disease by inhibiting the MAPK1 signal pathway. Exp Ther Med 20: 159, 2020.
APA
Deng, Y., Zhang, J., Sun, X., Ma, G., Luo, G., Miao, Z., & Song, L. (2020). miR‑132 improves the cognitive function of rats with Alzheimer's disease by inhibiting the MAPK1 signal pathway. Experimental and Therapeutic Medicine, 20, 159. https://doi.org/10.3892/etm.2020.9288
MLA
Deng, Y., Zhang, J., Sun, X., Ma, G., Luo, G., Miao, Z., Song, L."miR‑132 improves the cognitive function of rats with Alzheimer's disease by inhibiting the MAPK1 signal pathway". Experimental and Therapeutic Medicine 20.6 (2020): 159.
Chicago
Deng, Y., Zhang, J., Sun, X., Ma, G., Luo, G., Miao, Z., Song, L."miR‑132 improves the cognitive function of rats with Alzheimer's disease by inhibiting the MAPK1 signal pathway". Experimental and Therapeutic Medicine 20, no. 6 (2020): 159. https://doi.org/10.3892/etm.2020.9288
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team