Open Access

Effect of arsenic trioxide on cervical cancer and its mechanisms

  • Authors:
    • Liping Zhang
    • Yanan Zhou
    • Jing Kong
    • Li Zhang
    • Mengqin Yuan
    • Shu Xian
    • Yanqing Wang
    • Yanxiang Cheng
    • Xiaofeng Yang
  • View Affiliations

  • Published online on: October 9, 2020     https://doi.org/10.3892/etm.2020.9299
  • Article Number: 169
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical cancer is one of the most common types of gynecological tumor, and thus identifying complementary or substitute treatment methods to treat cervical cancer is important. The present study aimed to evaluate the effect of arsenic trioxide (ATO), a traditional Chinese medicine, on cervical cancer cells and its underlying mechanism. MTT, colony formation and Transwell assays were performed to investigate the effects of different concentrations of ATO on cell proliferation and invasion, respectively. Western blotting and reverse transcription‑quantitative PCR were applied to measure hypoxia‑inducible factor‑1α expression (HIF‑1α) expression following ATO treatment. Finally, the effects of HIF‑1α knockdown on cervical cancer cell proliferation, apoptosis and invasion were evaluated. The results demonstrated that ATO could inhibit cell proliferation and invasion. Moreover, ATO could induce reactive oxygen species production in a time‑ and dose‑dependent manner. ATO could also promote the apoptosis of cervical cancer cells via HIF‑1α. Therefore, the present study may provide a theoretical basis for identifying effective molecular targets for the prevention and treatment of cervical cancer.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang L, Zhou Y, Kong J, Zhang L, Yuan M, Xian S, Wang Y, Cheng Y and Yang X: Effect of arsenic trioxide on cervical cancer and its mechanisms. Exp Ther Med 20: 169, 2020
APA
Zhang, L., Zhou, Y., Kong, J., Zhang, L., Yuan, M., Xian, S. ... Yang, X. (2020). Effect of arsenic trioxide on cervical cancer and its mechanisms. Experimental and Therapeutic Medicine, 20, 169. https://doi.org/10.3892/etm.2020.9299
MLA
Zhang, L., Zhou, Y., Kong, J., Zhang, L., Yuan, M., Xian, S., Wang, Y., Cheng, Y., Yang, X."Effect of arsenic trioxide on cervical cancer and its mechanisms". Experimental and Therapeutic Medicine 20.6 (2020): 169.
Chicago
Zhang, L., Zhou, Y., Kong, J., Zhang, L., Yuan, M., Xian, S., Wang, Y., Cheng, Y., Yang, X."Effect of arsenic trioxide on cervical cancer and its mechanisms". Experimental and Therapeutic Medicine 20, no. 6 (2020): 169. https://doi.org/10.3892/etm.2020.9299