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Incidence, laboratory diagnosis and predictors of tracheobronchial tuberculosis in patients with pulmonary tuberculosis in Chongqing, China

  • Authors:
    • An-Zhou Peng
    • Ao Yang
    • Si-Ju Li
    • Qian Qiu
    • Song Yang
    • Yong Chen
  • View Affiliations / Copyright

    Affiliations: Department of Tuberculosis Laboratory, Public Health Medical Center, Chongqing 400036, P.R. China, Department of Traffic Injury Prevention Research Office, Daping Hospital, Army Medical Center of The PLA, Chongqing 400042, P.R. China
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 174
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    Published online on: October 9, 2020
       https://doi.org/10.3892/etm.2020.9304
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Abstract

Tracheobronchial tuberculosis (TBTB) is reported in 10‑40% of patients with pulmonary tuberculosis (PTB). Due to its non‑specific presentation, the diagnosis and management are frequently delayed. The aim of the present study was to investigate the incidence, predictors and laboratory diagnosis of concomitant TBTB and PTB in Chongqing, China. Bronchoscopy was performed in all patients with newly diagnosed or relapsed PTB in order to detect TBTB between January 2018 and April 2019 in a sub‑tertiary hospital in Chongqing, China. The clinical characteristics and laboratory data were analyzed to identify predictors and determine the diagnostic yield of TBTB. A total of 341 (31.4%) of the 1,085 patients with PTB who underwent the bronchoscopic examination presented with concomitant TBTB. The parameters of female sex [odds ratio (OR)=2.57], clinical symptoms (OR=6.26) and atelectasis (OR=4.3) were independent predictors of TBTB. Cough (OR=32.48) and atelectasis (OR=3.14) were independent predictors of TBTB‑associated tracheobronchial stenosis. The diagnostic yields of sputum smear, bronchial brush smear, sputum culture, GeneXpert Mycobacterium tuberculosis/rifampicin resistance (GX) using sputum, GX using brushings and in bronchial brush culture used for the diagnosis of TBTB were 44.2, 44.2, 63.5, 57.7, 71.2 and 75%, respectively. GX brushings had higher diagnostic yields compared with sputum or brush smears; however, there was no significant difference between sputum/brushings cultures and GX with sputum. The incidence of TBTB in PTB was 31.4% in Chongqing, China. The parameters of female sex, atelectasis and cough were the major predictors of concomitant TBTB and associated tracheobronchial stenosis. Although GX is an accurate and rapid test to detect TBTB, additional laboratory techniques should also be adopted to improve diagnostic yields in the detection of TBTB in patients with PTB.
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Copy and paste a formatted citation
Spandidos Publications style
Peng A, Yang A, Li S, Qiu Q, Yang S and Chen Y: Incidence, laboratory diagnosis and predictors of tracheobronchial tuberculosis in patients with pulmonary tuberculosis in Chongqing, China. Exp Ther Med 20: 174, 2020.
APA
Peng, A., Yang, A., Li, S., Qiu, Q., Yang, S., & Chen, Y. (2020). Incidence, laboratory diagnosis and predictors of tracheobronchial tuberculosis in patients with pulmonary tuberculosis in Chongqing, China. Experimental and Therapeutic Medicine, 20, 174. https://doi.org/10.3892/etm.2020.9304
MLA
Peng, A., Yang, A., Li, S., Qiu, Q., Yang, S., Chen, Y."Incidence, laboratory diagnosis and predictors of tracheobronchial tuberculosis in patients with pulmonary tuberculosis in Chongqing, China". Experimental and Therapeutic Medicine 20.6 (2020): 174.
Chicago
Peng, A., Yang, A., Li, S., Qiu, Q., Yang, S., Chen, Y."Incidence, laboratory diagnosis and predictors of tracheobronchial tuberculosis in patients with pulmonary tuberculosis in Chongqing, China". Experimental and Therapeutic Medicine 20, no. 6 (2020): 174. https://doi.org/10.3892/etm.2020.9304
Copy and paste a formatted citation
x
Spandidos Publications style
Peng A, Yang A, Li S, Qiu Q, Yang S and Chen Y: Incidence, laboratory diagnosis and predictors of tracheobronchial tuberculosis in patients with pulmonary tuberculosis in Chongqing, China. Exp Ther Med 20: 174, 2020.
APA
Peng, A., Yang, A., Li, S., Qiu, Q., Yang, S., & Chen, Y. (2020). Incidence, laboratory diagnosis and predictors of tracheobronchial tuberculosis in patients with pulmonary tuberculosis in Chongqing, China. Experimental and Therapeutic Medicine, 20, 174. https://doi.org/10.3892/etm.2020.9304
MLA
Peng, A., Yang, A., Li, S., Qiu, Q., Yang, S., Chen, Y."Incidence, laboratory diagnosis and predictors of tracheobronchial tuberculosis in patients with pulmonary tuberculosis in Chongqing, China". Experimental and Therapeutic Medicine 20.6 (2020): 174.
Chicago
Peng, A., Yang, A., Li, S., Qiu, Q., Yang, S., Chen, Y."Incidence, laboratory diagnosis and predictors of tracheobronchial tuberculosis in patients with pulmonary tuberculosis in Chongqing, China". Experimental and Therapeutic Medicine 20, no. 6 (2020): 174. https://doi.org/10.3892/etm.2020.9304
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