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Associated risk factors of lower limb lymphedema after treatment of cervical and endometrial cancer

  • Authors:
    • Laura Florentina Rebegea
    • Gabriela Stoleriu
    • Nicuta Manolache
    • Cristina Serban
    • Mihaela Craescu
    • Mary-Nicoleta Lupu
    • Doina Carina Voinescu
    • Dorel Firescu
    • Oana Roxana Ciobotaru
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy and Oncology, ‘St. Apostle Andrew’ County Emergency Clinical Hospital, 800179 Galați, Romania, Clinical Department, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800008 Galati, Romania, Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800008 Galati, Romania, Second Surgery Clinic, ‘St. Apostle Andrew’ County Emergency Clinical Hospital, 800179 Galati, Romania, Department of Surgery, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800008 Galati, Romania
    Copyright: © Rebegea et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 181
    |
    Published online on: October 13, 2020
       https://doi.org/10.3892/etm.2020.9311
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Abstract

The scope of the study was to identify the associated risk factors of lower limb lymphedema development in cervical and endometrial cancer patients. We retrospectively analysed 326 patients: 186 cases (57.06%) with cervical cancer and 140 cases (42.94%) with endometrial cancer were treated in Surgery, Radiotherapy, Oncology and Gynaecology Clinics of ‘St. Apostle Andrew’ Emergency Clinical Hospital Galati over 9 years. Adjuvant radiotherapy was performed in 83.57% of endometrial cancer cases. Adjuvant chemotherapy was performed in 45.16% of cervical cancer cases. Over 10 lymph nodes were removed in 74.73% of cervical cancer patients. Incidence of lymphedema was 15.05% in cervical cancer patients and 10% in endometrial cancer patients, P=0.06. Analysed risk factors for lower limb lymphedema occurrence were: Age, disease stage, radiotherapy, number of invaded lymph nodes (for cervical cancer patients), number of removed lymph nodes (for cervical cancer patients) and obesity. Multivariate analysis for associated risk factors of lower limb lymphedema development in cervical cancer showed that number of removed lymph nodes, OR=2.109 (0.907‑4.903), P<0.0001, number of lymph nodes with metastasis, OR=1.903 (0.253‑4.332), P=0.004 and obesity, OR=1.713 (0.226‑2.967), P=0.006 were found as statistically significant risk factors for lower limb lymphedema onset. For endometrial cancer patients, obesity, OR=1.518 (0.721‑2.75), P=0.0003, was the only associated risk factor with statistical significance for the lower limb lymphedema development. Lower limb lymphedema represents one of the adverse reactions of multimodal treatment in gynaecological cancers which affects patient's quality of life. Lower limb lymphedema occurrence is related with number of risk factors, the most important being removed lymph nodes, obesity and radiotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Rebegea LF, Stoleriu G, Manolache N, Serban C, Craescu M, Lupu M, Voinescu DC, Firescu D and Ciobotaru OR: Associated risk factors of lower limb lymphedema after treatment of cervical and endometrial cancer. Exp Ther Med 20: 181, 2020.
APA
Rebegea, L.F., Stoleriu, G., Manolache, N., Serban, C., Craescu, M., Lupu, M. ... Ciobotaru, O.R. (2020). Associated risk factors of lower limb lymphedema after treatment of cervical and endometrial cancer. Experimental and Therapeutic Medicine, 20, 181. https://doi.org/10.3892/etm.2020.9311
MLA
Rebegea, L. F., Stoleriu, G., Manolache, N., Serban, C., Craescu, M., Lupu, M., Voinescu, D. C., Firescu, D., Ciobotaru, O. R."Associated risk factors of lower limb lymphedema after treatment of cervical and endometrial cancer". Experimental and Therapeutic Medicine 20.6 (2020): 181.
Chicago
Rebegea, L. F., Stoleriu, G., Manolache, N., Serban, C., Craescu, M., Lupu, M., Voinescu, D. C., Firescu, D., Ciobotaru, O. R."Associated risk factors of lower limb lymphedema after treatment of cervical and endometrial cancer". Experimental and Therapeutic Medicine 20, no. 6 (2020): 181. https://doi.org/10.3892/etm.2020.9311
Copy and paste a formatted citation
x
Spandidos Publications style
Rebegea LF, Stoleriu G, Manolache N, Serban C, Craescu M, Lupu M, Voinescu DC, Firescu D and Ciobotaru OR: Associated risk factors of lower limb lymphedema after treatment of cervical and endometrial cancer. Exp Ther Med 20: 181, 2020.
APA
Rebegea, L.F., Stoleriu, G., Manolache, N., Serban, C., Craescu, M., Lupu, M. ... Ciobotaru, O.R. (2020). Associated risk factors of lower limb lymphedema after treatment of cervical and endometrial cancer. Experimental and Therapeutic Medicine, 20, 181. https://doi.org/10.3892/etm.2020.9311
MLA
Rebegea, L. F., Stoleriu, G., Manolache, N., Serban, C., Craescu, M., Lupu, M., Voinescu, D. C., Firescu, D., Ciobotaru, O. R."Associated risk factors of lower limb lymphedema after treatment of cervical and endometrial cancer". Experimental and Therapeutic Medicine 20.6 (2020): 181.
Chicago
Rebegea, L. F., Stoleriu, G., Manolache, N., Serban, C., Craescu, M., Lupu, M., Voinescu, D. C., Firescu, D., Ciobotaru, O. R."Associated risk factors of lower limb lymphedema after treatment of cervical and endometrial cancer". Experimental and Therapeutic Medicine 20, no. 6 (2020): 181. https://doi.org/10.3892/etm.2020.9311
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