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Article

Measurement of skin viscoelasticity: A non‑invasive approach in allergic contact dermatitis

  • Authors:
    • Maria-Magdalena Constantin
    • Stefana Bucur
    • Elena-Daniela Serban
    • Rodica Olteanu
    • Ovidiu Gabriel Bratu
    • Traian Constantin
  • View Affiliations / Copyright

    Affiliations: The Second Department of Dermatology, Colentina Clinical Hospital, 020125 Bucharest, Romania, 3rd Department, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
  • Article Number: 184
    |
    Published online on: October 13, 2020
       https://doi.org/10.3892/etm.2020.9314
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Abstract

Non‑invasive bioengineering technologies are constantly being developed, as they can provide useful insights and contribute to the improvement of medical care and scientific education. The purpose of this study was to assess skin viscoelasticity using the suction chamber method in patients with allergic contact dermatitis vs. healthy subjects, before and after applying a moisturizer safety testing cream. This was a prospective controlled study over a 3‑year period (March 2016‑March 2019), with 81 subjects being divided in two balanced groups: Patients with allergic contact dermatitis and healthy subjects, respectively. The skin viscoelasticity was determined for all subjects with Cutometer®, using the suction method, by performing a dynamic assessment of parameters before and after applying a moisturizing cream. The results indicate a decrease in the elasticity parameters in both groups, indicating an improvement of the elastic properties under the treatment. Skin capacity to return to its previous form after the deformation, i.e., pure elasticity and biological elasticity, showed overall elevated values in the group with contact dermatitis, demonstrating the efficacy of the emollient cream after applying it for 28 days (increase by 11.7 and 4.9% respectively, compared with baseline, when patients had dry, untreated skin). However, in healthy subjects, these parameters do not achieve important values, but they remain rather stable over time with a very slight improvement (6.6% after 28 days). The Cutometer is an easy to use, efficient and widely used instrument for measurements in studies that perform a quantitative assessment of the effectiveness of different formulations intended for application on the skin.
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1 

Piérard GE: A critical approach to in vivo mechanical testing of the skin. In: Lévèque JL (ed) Cutaneous investigation in health and disease, noninvasive methods and instrumentation. Informa healthcare, New York, 1989.

2 

Larrabee WF Jr: A finite element model of skin deformation. I. Biomechanics of skin and soft tissue: A review. Laryngoscope. 96:399–405. 1986.PubMed/NCBI

3 

Constantin MM: Value and impact of patch testing in patients with allergic contact dermatitis. Rev Română de Medicină de Lab. 20:287–292. 2012.

4 

Olteanu R, Constantin MM, Zota A, Dorobantu DM, Constantin T, Serban ED, Bălănescu P, Mihele D and Gheucă Solovăstru L: Original clinical experience and approach to treatment study with interleukine 12/23 inhibitor in moderate-to-severe psoriasis patients. Farmacia. 64(6)2016.

5 

Olteanu R, Zota A and Constantin M: Biosimilars: An update on clinical trials (Review of Published and Ongoing Studies). Acta Dermatovenerol Croat. 25:57–66. 2017.PubMed/NCBI

6 

Solovăstru LG, Vâţă D, Stătescu L, Constantin MM and Andrese E: Skin cancer between myth and reality, yet ethically constrained. Rev Română de Bioetică. 12:47–52. 2014.

7 

Iorga RA, Bratu OG, Marcu RD, Constantin T, Mischianu DLD, Socea B, Gaman MA and Diaconu CC: Venous thromboembolism in cancer patients: Still looking for answers (Review). Exp Ther Med. 18:5026–5032. 2019.PubMed/NCBI View Article : Google Scholar

8 

Constantin MM, Poenaru E, Poenaru C and Constantin T: Skin hydration assessment through modern non-invasive bioengineering technologies. Maedica (Buchar). 9:33–38. 2014.PubMed/NCBI

9 

Serup J: Mechanical properties of human skin: Elasticity parameters and their relevance. In: Elsner P, Berardesca E, Wilhelm KP and Maibach HI (eds). Bioengineering and the skin. Skin biomechanics. CRC Press, Boca Raton, pp41-47, 2002.

10 

Agache PG, Monneur C, Leveque JL and De Rigal J: Mechanical properties and Young's modulus of human skin in vivo. Arch Dematol Res. 269:221–232. 1980.PubMed/NCBI View Article : Google Scholar

11 

Dobrev HP: A study of human skin mechanical properties by mean of cutometer. Folia Med (Plovdiv). 44:5–10. 2002.PubMed/NCBI

12 

Ryu JS, Joo YH, Kim SO, Park KC and Youn SW: Influence of age and regional differences on skin elasticity as measured by the cutometer. Skin Res Technol. 14:354–358. 2008.PubMed/NCBI View Article : Google Scholar

13 

Smalls LK, Randall Wickett R and Visscher MO: Effect of dermal thickness, tissue composition, and body site on skin biomechanical properties. Skin Res Technol. 12:43–49. 2006.PubMed/NCBI View Article : Google Scholar

14 

Beiu C, Popescu MN, Dumitrascu MC, Petca A, Mehedințu C, Farcasanu PD, Petca RC, Chibelean C and Șandru F: The evaluation of Estrogen Receptor β as a potential prognostic factor in melanoma. Rev Chim (Bucharest). 70:4212–4216. 2019.

15 

Qu D and Seehra GP: Improving the accuracy of skin elasticity measurement by using Q-parameters in cutometer. J Cosmet Sci. 67:37–44. 2016.PubMed/NCBI

16 

Dobrev H: Use of cutometer to assess epidermal hydration. Skin Res Technol. 6:239–244. 2000.PubMed/NCBI View Article : Google Scholar

17 

Dobrev H: Use of cutometer to assess dermal oedema in erysipelas of the lower legs. Skin Res Technol. 4:155–159. 1998.PubMed/NCBI View Article : Google Scholar

18 

Held M, Rothenberger J, Tolzmann D, Petersen W, Schaller HE and Rahmanian-Schwarz A: Alteration of biomechanical properties of skin during the course of healing of partial-thickness wounds. Wounds. 27:123–128. 2015.PubMed/NCBI

19 

Podgórna K, Kołodziejczak A and Rotsztejn H: Cutometric assessment of elasticity of skin with striae distensae following carboxytherapy. J Cosmet Dermatol. 17:1170–1174. 2018.PubMed/NCBI View Article : Google Scholar

20 

Ilie MA, Caruntu C, Lixandru D, Tampa M, Georgescu SR, Constantin MM, Constantin C, Neagu M, Zurac SA and Boda D: In vivo confocal laser scanning microscopy imaging of skin inflammation: Clinical applications and research directions. Exp Ther Med. 17:1004–1011. 2019.PubMed/NCBI View Article : Google Scholar

21 

Căruntu C and Boda D: Evaluation through in vivo reflectance confocal microscopy of the cutaneous neurogenic inflammatory reaction induced by capsaicin in human subjects. J Biomed Opt. 17(085003)2012.PubMed/NCBI View Article : Google Scholar

22 

Vajaitu C, Draghici CC, Solomon I, Lisievici CV, Popa AV, Lupu M, Caruntu C, Constantin MM and Voiculescu VM: The central role of inflammation associated with checkpoint inhibitor treatments. J Immunol Res. 2018(4625472)2018.PubMed/NCBI View Article : Google Scholar

23 

Yilmaz E and Borchert HH: Effect of lipid-containing, positively charged nanoemulsions on skin hydration, elasticity and erythema - an in vivo study. Int J Pharm. 307:232–238. 2006.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Constantin M, Bucur S, Serban E, Olteanu R, Bratu OG and Constantin T: Measurement of skin viscoelasticity: A non‑invasive approach in allergic contact dermatitis. Exp Ther Med 20: 184, 2020.
APA
Constantin, M., Bucur, S., Serban, E., Olteanu, R., Bratu, O.G., & Constantin, T. (2020). Measurement of skin viscoelasticity: A non‑invasive approach in allergic contact dermatitis. Experimental and Therapeutic Medicine, 20, 184. https://doi.org/10.3892/etm.2020.9314
MLA
Constantin, M., Bucur, S., Serban, E., Olteanu, R., Bratu, O. G., Constantin, T."Measurement of skin viscoelasticity: A non‑invasive approach in allergic contact dermatitis". Experimental and Therapeutic Medicine 20.6 (2020): 184.
Chicago
Constantin, M., Bucur, S., Serban, E., Olteanu, R., Bratu, O. G., Constantin, T."Measurement of skin viscoelasticity: A non‑invasive approach in allergic contact dermatitis". Experimental and Therapeutic Medicine 20, no. 6 (2020): 184. https://doi.org/10.3892/etm.2020.9314
Copy and paste a formatted citation
x
Spandidos Publications style
Constantin M, Bucur S, Serban E, Olteanu R, Bratu OG and Constantin T: Measurement of skin viscoelasticity: A non‑invasive approach in allergic contact dermatitis. Exp Ther Med 20: 184, 2020.
APA
Constantin, M., Bucur, S., Serban, E., Olteanu, R., Bratu, O.G., & Constantin, T. (2020). Measurement of skin viscoelasticity: A non‑invasive approach in allergic contact dermatitis. Experimental and Therapeutic Medicine, 20, 184. https://doi.org/10.3892/etm.2020.9314
MLA
Constantin, M., Bucur, S., Serban, E., Olteanu, R., Bratu, O. G., Constantin, T."Measurement of skin viscoelasticity: A non‑invasive approach in allergic contact dermatitis". Experimental and Therapeutic Medicine 20.6 (2020): 184.
Chicago
Constantin, M., Bucur, S., Serban, E., Olteanu, R., Bratu, O. G., Constantin, T."Measurement of skin viscoelasticity: A non‑invasive approach in allergic contact dermatitis". Experimental and Therapeutic Medicine 20, no. 6 (2020): 184. https://doi.org/10.3892/etm.2020.9314
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