Effect of inulin in the treatment of irritable bowel syndrome with constipation (Review)

Bărboi,Oana-Bogdana; Ciortescu,Irina; Chirilă,Ioan; Anton,Carmen; Drug,Vasile

doi:10.3892/etm.2020.9315

Effect of inulin in the treatment of irritable bowel syndrome with constipation (Review)

Authors:
- Oana-Bogdana Bărboi
- Irina Ciortescu
- Ioan Chirilă
- Carmen Anton
- Vasile Drug
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Affiliations: Department of Gastroenterology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Health Related to Environment Department, National Institute of Public Health, 700506 Iasi, Romania
Published online on: October 13, 2020 https://doi.org/10.3892/etm.2020.9315
Article Number: 185

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Abstract

At present, irritable bowel syndrome (IBS) is a common medical problem all over the world that implies considerable social burden and high costs. Considering the different pathophysiological pathways, unitary management for IBS is not possible. Of the therapeutic approaches that have been proposed so far, only a few have been demonstrated to have beneficial effects in IBS patients. The implication of gut microbiota in IBS is obvious, similarly to the therapeutic effect of pro‑/prebiotics, which is reflected by the latest publications. The intake of inulin seems to regulate the bowel peristalsis and colonic transit, the consistency and frequency of the stools, as it changes the composition of gut microbiota. The beneficial effect of inulin in patients with IBS‑constipation form (IBS‑C) is obvious, but still, more randomized controlled clinical trials involving large samples of patients are needed in order to provide more evidence.

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1	Dahl WJ and Stewart ML: Position of the Academy of Nutrition and Dietetics: Health implications of dietary fiber. J Acad Nutr Diet. 115:1861–1870. 2015.PubMed/NCBI View Article : Google Scholar
2	Schmier JK, Miller PE, Levine JA, Perez V, Maki KC, Rains TM, Devareddy L, Sanders LM and Alexander DD: Cost savings of reduced constipation rates attributed to increased dietary fiber intakes: A decision-analytic model. BMC Public Health. 14(374)2014.PubMed/NCBI View Article : Google Scholar
3	David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, et al: Diet rapidly and reproducibly alters the human gut microbiome. Nature. 505:559–563. 2014.PubMed/NCBI View Article : Google Scholar
4	Slavin J: Fiber and prebiotics: Mechanisms and health benefits. Nutrients. 5:1417–1435. 2013.PubMed/NCBI View Article : Google Scholar
5	Micka A, Siepelmeyer A, Holz A, Theis S and Schön C: Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: A randomized, double-blind, placebo-controlled trial. Int J Food Sci Nutr. 68:82–89. 2017.PubMed/NCBI View Article : Google Scholar
6	Öhman L and Simrén M: Intestinal microbiota and its role in irritable bowel syndrome (IBS). Curr Gastroenterol Rep. 15(323)2013.PubMed/NCBI View Article : Google Scholar
7	Kleessen B, Schwarz S, Boehm A, Fuhrmann H, Richter A, Henle T and Krueger M: Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers. Br J Nutr. 98:540–549. 2007.PubMed/NCBI View Article : Google Scholar
8	Ramnani P, Gaudier E, Bingham M, van Bruggen P, Tuohy KM and Gibson GR: Prebiotic effect of fruit and vegetable shots containing Jerusalem artichoke inulin: A human intervention study. Br J Nutr. 104:233–240. 2010.PubMed/NCBI View Article : Google Scholar
9	Morales-Filho JP and Quigley EM: The intestinal microbiota and the role of probiotics in irritable bowel syndrome: A review. Arq Gastroenterol. 52:331–338. 2015.PubMed/NCBI View Article : Google Scholar
10	Collado Yurrita L, San Mauro Martín I, Ciudad-Cabañas MJ, Calle-Purón ME and Hernández Cabria M: Effectiveness of inulin intake on indicators of chronic constipation; a meta-analysis of controlled randomized clinical trials. Nutr Hosp. 30:244–252. 2014.PubMed/NCBI View Article : Google Scholar
11	Gruenwald J, Busch R and Bentley C: Efficacy and tolerability of Laxatan Granulat in patients with chronic constipation. Clin Exp Gastroenterol. 2:95–100. 2009.PubMed/NCBI View Article : Google Scholar
12	Hond ED, Geypens B and Ghoos Y: Effect of high performance chicory inulin on constipation. Nutr Res. 20:731–736. 2000.
13	Isakov VA, Pilipenko VI, Shakhovskaya A and Tutelyan V: Efficacy of inulin enriched yogurt on bowel habits in patients with irritable bowel syndrome with constipation: A pilot study. FASEB J. 27(lb426)2013.
14	Gråsten S, Liukkonen KH, Chrevatidis A, El-Nezami H, Poutanen K and Mykkänen H: Effects of wheat pentosan and inulin on the metabolic activity of fecal microbiota and on bowel function in healthy humans. Nutrit Res. 23:1503–1514. 2003.
15	EFSA Panel on Dietetic Products, Nutrition and Allergies. Scientific opinion on the substantiation of a health claim related to ‘native chicory inulin’ and maintenance of normal defecation by increasing stool frequency pursuant to Article 13.5 of Regulation (EC) No 1924/20061. EFSA J. 13(3951)2015.
16	Vandeputte D, Falony G, Vieira-Silva S, Wang J, Sailer M, Theis S, Verbeke K and Raes J: Prebiotic inulin-type fructans induce specific changes in the human gut microbiota. Gut. 66:1968–1974. 2017.PubMed/NCBI View Article : Google Scholar
17	Dewulf EM, Cani PD, Claus SP, Fuentes S, Puylaert PG, Neyrinck AM, Bindels LB, de Vos WM, Gibson GR, Thissen JP and Delzenne NM: Insight into the prebiotic concept: Lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women. Gut. 62:1112–1121. 2013.PubMed/NCBI View Article : Google Scholar
18	Linetzky Waitzberg D, Alves Pereira CC, Logullo L, Manzoni Jacintho T, Almeida D, Teixeira da Silva ML and Matos de Miranda Torrinhas RS: Microbiota benefits after inulin and partially hydrolized guar gum supplementation: A randomized clinical trial in constipated women. Nutr Hosp. 27:123–129. 2012.PubMed/NCBI View Article : Google Scholar
19	Watson AW, Houghton D, Avery PJ, Stewart C, Vaughan EE, Meyer PD, de Bos Kuil MJJ, Weijs PJM and Brandt K: Changes in stool frequency following chicory inulin consumption, and effects on stool consistency, quality of life and composition of gut microbiota. Food Hydrocoll. 96:688–698. 2019.PubMed/NCBI View Article : Google Scholar