Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2020 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2020 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Prediction of NAFLD occurrence in prediabetes patients

  • Authors:
    • Cosmin Mihai Vesa
    • Tapan Behl
    • Sebestian Nemeth
    • Ovidiu G. Bratu
    • Camelia C. Diaconu
    • Radu Dumitru Moleriu
    • Nicoleta Negrut
    • Dana C. Zaha
    • Cristiana Bustea
    • Florentina Ionita Radu
    • Simona Bungau
  • View Affiliations / Copyright

    Affiliations: Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania, Chitkara College of Pharmacy, Chitkara University, 140401 Punjab, India, Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania, Clinical Department 3, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department 5, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Mathematics, Faculty of Mathematics and Computer Science, West University of Timisoara, 300223 Timisoara, Romania, Department of Psycho‑Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania, Department of Gastroenterology, Emergency University Central Military Hospital, 010825 Bucharest, Romania
  • Article Number: 190
    |
    Published online on: October 13, 2020
       https://doi.org/10.3892/etm.2020.9320
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Non‑alcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome that significantly increases the cardiovascular risk of patients with glucose metabolism alterations. This study identified the prevalence of NAFLD, predictors of NAFLD and explored the link between insulin sensitivity, insulin resistance and leptinemia in 143 patients registered with prediabetes. Abdominal ultrasound was performed, and fasting insulin, postprandial insulin, leptin levels, common clinical/biochemical determinations were assessed. Certain variables that can predict NAFLD existence were determined and it was found that there is a high prevalence of NAFLD in patients with prediabetes. In univariate analysis, statistically significant associations (P<0.05) were found between waist circumference, systolic blood pressure, diastolic blood pressure, triglycerides, HDL‑cholesterol, insulin sensitivity, β‑cell function, leptin and NAFLD presence. The coefficients for the variables which obtain statistically significant association (P<0.05) are low, except for leptin which is the biochemical parameter that (in both univariate and multivariate analysis) is a strong predictor of NAFLD presence.
View Figures
View References

1 

Caldwell S and Argo C: The natural history of non-alcoholic fatty liver disease. Dig Dis. 28:162–168. 2010.PubMed/NCBI View Article : Google Scholar

2 

Portillo-Sanchez P, Bril F, Maximos M, Lomonaco R, Bermacki D, Orsak B, Subbarayan S, Webb A, Hecht J and Cusi K: High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels. J Clin Endocrinol Metab. 100:2231–2238. 2015.PubMed/NCBI View Article : Google Scholar

3 

Hazlehurst JM, Woods C, Marjot T, Cobbold JF and Tomlinson JW: Non-alcoholic fatty liver disease and diabetes. Metabolism. 65:1096–1108. 2016.PubMed/NCBI View Article : Google Scholar

4 

Shibata M, Kihara Y, Taguchi M, Tashiro M and Otsuki M: Nonalcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men. Diabetes Care. 30:2940–2944. 2007.PubMed/NCBI View Article : Google Scholar

5 

Chen Z, Yu R, Xiong Y, Du F and Zhu S: A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease. Lipids Health Dis. 16(203)2017.PubMed/NCBI View Article : Google Scholar

6 

Veyrat-Durebex C, Poher AL, Caillon A, Somm E, Vallet P, Charnay Y and Rohner-Jeanrenaud F: Improved leptin sensitivity as a potential candidate responsible for the spontaneous food restriction of the Lou/C rat. PLoS One. 8(e73452)2013.PubMed/NCBI View Article : Google Scholar

7 

Nishi T, Babazono A, Maeda T, Imatoh T and Une H: Evaluation of the fatty liver index as a predictor for the development of diabetes among insurance beneficiaries with prediabetes. J Diabetes Investig. 6:309–316. 2014.PubMed/NCBI View Article : Google Scholar

8 

Schneider AL, Lazo M, Ndumele CE, Pankow JS, Coresh J, Clark JM and Selvin E: Liver enzymes, race, gender and diabetes risk, the atherosclerosis risk in communities (ARIC) study. Diabet Med. 30:926–933. 2013.PubMed/NCBI View Article : Google Scholar

9 

Remus Popa A, Fratila O, Rus M, Anca Corb Aron R, Vesa CM, Pantis C, Diaconu C, Bratu O, Bungau S and Nemeth S: Risk factors for adiposity in the urban population and influence on the prevalence of overweight and obesity. Exp Ther Med. 20:129–133. 2020.PubMed/NCBI View Article : Google Scholar

10 

Vesa CM, Popa L, Popa AR, Rus M, Zaha AA, Bungau S, Tit DM, Corb Aron RA and Zaha DC: Current data regarding the relationship between type 2 diabetes mellitus and cardiovascular risk factors. Diagnostics. 10(314)2020.PubMed/NCBI View Article : Google Scholar

11 

Zhou Y and Rui L: Leptin signalling and leptin resistance. Front Med. 7:207–222. 2013.PubMed/NCBI View Article : Google Scholar

12 

Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, et al: Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity. J Neurosci. 29:11582–11593. 2009.PubMed/NCBI View Article : Google Scholar

13 

American Diabetes Association. 2. Classification and diagnosis of diabetes: Standards of medical care in diabetes-2020. Diabetes Care. 43 (Suppl 1):S14–S31. 2020.PubMed/NCBI View Article : Google Scholar

14 

Abdel-Daim MM, El-Tawil OS, Bungau SG and Atanasov AG: Applications of antioxidants in metabolic disorders and degenerative diseases: Mechanistic approach. Oxid Med Cell Longev. 2019(4179676)2019.PubMed/NCBI View Article : Google Scholar

15 

Pappachan JM, Babu S, Krishnan B and Ravindran NC: Non-alcoholic fatty liver disease: A clinical update. J Clin Transl Hepatol. 5:384–393. 2017.PubMed/NCBI View Article : Google Scholar

16 

Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L and Wymer M: Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 64:73–84. 2016.PubMed/NCBI View Article : Google Scholar

17 

Balkau B, Lange C, Vol S, Fumeron F and Bonnet F: Group Study D.E.S.I.R. Nine-year incident diabetes is predicted by fatty liver indices: The French D.E.S.I.R study. BMC Gastroenterol. 10(56)2010.PubMed/NCBI View Article : Google Scholar

18 

Bedogni G, Bellentani S, Miglioli L, Masutti F, Passalacqua M, Castiglione A and Tiribelli C: The fatty liver index: A simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol. 6(33)2006.PubMed/NCBI View Article : Google Scholar

19 

Cansanção K, Silva Monteiro L, Carvalho Leite N, Dávalos A, Tavares do Carmo MDG and Arantes Ferreira Peres W: Advanced liver fibrosis is independently associated with palmitic acid and insulin levels in patients with non-alcoholic fatty liver disease. Nutrients. 10(1586)2018.PubMed/NCBI View Article : Google Scholar

20 

Denkmayr L, Feldman A, Stechemesser L, Eder SK, Zandanell S, Schranz M, Strasser M, Huber-Schönauer U, Buch S, Hampe J, et al: Lean patients with non-alcoholic fatty liver disease have a severe histological phenotype similar to obese patients. J Clin Med. 7(562)2018.PubMed/NCBI View Article : Google Scholar

21 

Diaconu C, Salmen T, Gaman MA, Bratu OG, Mischianu D, Marcu RD, Suceveanu AI, Costache RS and Pantea Stoian A: SGLT2 inhibition in patients with type 2 diabetes and cardiovascular diseases: Which are the benefits? Rom J Mil Med. 122:16–21. 2019.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Vesa CM, Behl T, Nemeth S, Bratu OG, Diaconu CC, Moleriu RD, Negrut N, Zaha DC, Bustea C, Radu FI, Radu FI, et al: Prediction of NAFLD occurrence in prediabetes patients. Exp Ther Med 20: 190, 2020.
APA
Vesa, C.M., Behl, T., Nemeth, S., Bratu, O.G., Diaconu, C.C., Moleriu, R.D. ... Bungau, S. (2020). Prediction of NAFLD occurrence in prediabetes patients. Experimental and Therapeutic Medicine, 20, 190. https://doi.org/10.3892/etm.2020.9320
MLA
Vesa, C. M., Behl, T., Nemeth, S., Bratu, O. G., Diaconu, C. C., Moleriu, R. D., Negrut, N., Zaha, D. C., Bustea, C., Radu, F. I., Bungau, S."Prediction of NAFLD occurrence in prediabetes patients". Experimental and Therapeutic Medicine 20.6 (2020): 190.
Chicago
Vesa, C. M., Behl, T., Nemeth, S., Bratu, O. G., Diaconu, C. C., Moleriu, R. D., Negrut, N., Zaha, D. C., Bustea, C., Radu, F. I., Bungau, S."Prediction of NAFLD occurrence in prediabetes patients". Experimental and Therapeutic Medicine 20, no. 6 (2020): 190. https://doi.org/10.3892/etm.2020.9320
Copy and paste a formatted citation
x
Spandidos Publications style
Vesa CM, Behl T, Nemeth S, Bratu OG, Diaconu CC, Moleriu RD, Negrut N, Zaha DC, Bustea C, Radu FI, Radu FI, et al: Prediction of NAFLD occurrence in prediabetes patients. Exp Ther Med 20: 190, 2020.
APA
Vesa, C.M., Behl, T., Nemeth, S., Bratu, O.G., Diaconu, C.C., Moleriu, R.D. ... Bungau, S. (2020). Prediction of NAFLD occurrence in prediabetes patients. Experimental and Therapeutic Medicine, 20, 190. https://doi.org/10.3892/etm.2020.9320
MLA
Vesa, C. M., Behl, T., Nemeth, S., Bratu, O. G., Diaconu, C. C., Moleriu, R. D., Negrut, N., Zaha, D. C., Bustea, C., Radu, F. I., Bungau, S."Prediction of NAFLD occurrence in prediabetes patients". Experimental and Therapeutic Medicine 20.6 (2020): 190.
Chicago
Vesa, C. M., Behl, T., Nemeth, S., Bratu, O. G., Diaconu, C. C., Moleriu, R. D., Negrut, N., Zaha, D. C., Bustea, C., Radu, F. I., Bungau, S."Prediction of NAFLD occurrence in prediabetes patients". Experimental and Therapeutic Medicine 20, no. 6 (2020): 190. https://doi.org/10.3892/etm.2020.9320
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team