Prediction of NAFLD occurrence in prediabetes patients

  • Authors:
    • Cosmin Mihai Vesa
    • Tapan Behl
    • Sebestian Nemeth
    • Ovidiu G. Bratu
    • Camelia C. Diaconu
    • Radu Dumitru Moleriu
    • Nicoleta Negrut
    • Dana C. Zaha
    • Cristiana Bustea
    • Florentina Ionita Radu
    • Simona Bungau
  • View Affiliations

  • Published online on: October 13, 2020     https://doi.org/10.3892/etm.2020.9320
  • Article Number: 190
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Abstract

Non‑alcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome that significantly increases the cardiovascular risk of patients with glucose metabolism alterations. This study identified the prevalence of NAFLD, predictors of NAFLD and explored the link between insulin sensitivity, insulin resistance and leptinemia in 143 patients registered with prediabetes. Abdominal ultrasound was performed, and fasting insulin, postprandial insulin, leptin levels, common clinical/biochemical determinations were assessed. Certain variables that can predict NAFLD existence were determined and it was found that there is a high prevalence of NAFLD in patients with prediabetes. In univariate analysis, statistically significant associations (P<0.05) were found between waist circumference, systolic blood pressure, diastolic blood pressure, triglycerides, HDL‑cholesterol, insulin sensitivity, β‑cell function, leptin and NAFLD presence. The coefficients for the variables which obtain statistically significant association (P<0.05) are low, except for leptin which is the biochemical parameter that (in both univariate and multivariate analysis) is a strong predictor of NAFLD presence.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Vesa CM, Behl T, Nemeth S, Bratu OG, Diaconu CC, Moleriu RD, Negrut N, Zaha DC, Bustea C, Radu FI, Radu FI, et al: Prediction of NAFLD occurrence in prediabetes patients. Exp Ther Med 20: 190, 2020
APA
Vesa, C.M., Behl, T., Nemeth, S., Bratu, O.G., Diaconu, C.C., Moleriu, R.D. ... Bungau, S. (2020). Prediction of NAFLD occurrence in prediabetes patients. Experimental and Therapeutic Medicine, 20, 190. https://doi.org/10.3892/etm.2020.9320
MLA
Vesa, C. M., Behl, T., Nemeth, S., Bratu, O. G., Diaconu, C. C., Moleriu, R. D., Negrut, N., Zaha, D. C., Bustea, C., Radu, F. I., Bungau, S."Prediction of NAFLD occurrence in prediabetes patients". Experimental and Therapeutic Medicine 20.6 (2020): 190.
Chicago
Vesa, C. M., Behl, T., Nemeth, S., Bratu, O. G., Diaconu, C. C., Moleriu, R. D., Negrut, N., Zaha, D. C., Bustea, C., Radu, F. I., Bungau, S."Prediction of NAFLD occurrence in prediabetes patients". Experimental and Therapeutic Medicine 20, no. 6 (2020): 190. https://doi.org/10.3892/etm.2020.9320