Interactions between leptin and insulin resistance in patients with prediabetes, with and without NAFLD

  • Authors:
    • Simona Bungau
    • Tapan Behl
    • Delia Mirela Tit
    • Florin Banica
    • Ovidiu G. Bratu
    • Camelia C. Diaconu
    • Carmen D. Nistor‑Cseppento
    • Cristiana Bustea
    • Raluca A. Corb Aron
    • Cosmin Mihai Vesa
  • View Affiliations

  • Published online on: October 14, 2020     https://doi.org/10.3892/etm.2020.9327
  • Article Number: 197
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Abstract

This study explored the link between insulin sensitivity, insulin resistance and leptinaemia in people with prediabetes with and without non‑alcoholic fatty liver disease (NAFLD). A total of 143 prediabetes patients were evaluated in the study. Ultrasonography was used for diagnosis of NAFLD, and fasting insulin, postprandial insulin, leptin levels, common clinical/biochemical determinations were determined. In total, 69 (48.25%) of the patients were diagnosed with NAFLD and 74 (51.75%) without NAFLD. Leptin values correlated statistically with fasting insulin in prediabetes patients, while in the patients that were also diagnosed with NAFLD the correlation was stronger. Values of log‑leptin <1 ng/ml were found in 64% of patients with prediabetes without NAFLD, and in 2% of patients with prediabetes and NAFLD. In the context of the association between serum leptin levels and a worse biochemical profile in prediabetes patients on one hand, and fatty liver disease and a worse biochemical profile in prediabetes patients on the other, leptin can be considered a possible candidate molecule that mediates the biochemical alterations identified in these patients.
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December-2020
Volume 20 Issue 6

Print ISSN: 1792-0981
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Spandidos Publications style
Bungau S, Behl T, Tit DM, Banica F, Bratu OG, Diaconu CC, Nistor‑Cseppento CD, Bustea C, Aron RA, Vesa CM, Vesa CM, et al: Interactions between leptin and insulin resistance in patients with prediabetes, with and without NAFLD. Exp Ther Med 20: 197, 2020.
APA
Bungau, S., Behl, T., Tit, D.M., Banica, F., Bratu, O.G., Diaconu, C.C. ... Vesa, C.M. (2020). Interactions between leptin and insulin resistance in patients with prediabetes, with and without NAFLD. Experimental and Therapeutic Medicine, 20, 197. https://doi.org/10.3892/etm.2020.9327
MLA
Bungau, S., Behl, T., Tit, D. M., Banica, F., Bratu, O. G., Diaconu, C. C., Nistor‑Cseppento, C. D., Bustea, C., Aron, R. A., Vesa, C. M."Interactions between leptin and insulin resistance in patients with prediabetes, with and without NAFLD". Experimental and Therapeutic Medicine 20.6 (2020): 197.
Chicago
Bungau, S., Behl, T., Tit, D. M., Banica, F., Bratu, O. G., Diaconu, C. C., Nistor‑Cseppento, C. D., Bustea, C., Aron, R. A., Vesa, C. M."Interactions between leptin and insulin resistance in patients with prediabetes, with and without NAFLD". Experimental and Therapeutic Medicine 20, no. 6 (2020): 197. https://doi.org/10.3892/etm.2020.9327