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Follicle‑stimulating hormone receptor gene polymorphisms of ovarian reserve markers in Romanian population

  • Authors:
    • Adina-Elena Tănase
    • Dragos Nemescu
    • Roxana Popescu
    • Alexandru  Carauleanu
    • Raluca Anamaria Mogos
    • Alexandru Luca
    • Mircea Onofriescu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Genetics, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
    Copyright: © Tănase et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 203
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    Published online on: October 14, 2020
       https://doi.org/10.3892/etm.2020.9333
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Abstract

Association between phenotype and follicle‑stimulating hormone (FSH) receptor and FSH beta chain genotype was evaluated in women with ovarian dysfunction. FSH receptor gene single nucleotide polymorphisms (SNPs) were analyzed by restricted fragment length polymorphism (RFLP) technique. Three groups were analyzed: two groups formed of poor responders (women with ovarian dysfunctions caused by endometriosis and patients who underwent ovarian stimulation protocols) and a third good responders group (normal‑ovulatory women who gave birth to naturally conceived children). A higher average level of basal FSH values were found in mutants in the A919G/Ala307Thr/rs6165 or A2039G/Asn680Ser/rs6166 tests (7.16±1.09; P=0.659). Anti‑mullerian hormone (AMH) below 1.2 ng/ml was associated with a higher frequency of mutations: 33.3% A919G/Ala307Thr and A2039G/Asn680Ser (P=0.137) and also in 66.6% FSH receptor less frequent polymorphism (c.‑29G>A) rs 1394205 (P=0.522). The age, day 3 FSH, and AMH levels are widely used to investigate female infertility. However, we have not yet found the ideal biomarker to determine the best outcome and treatment plan for our patients. We cconsider that genetic markers will become the future in the personalization of controlled ovarian stimulation treatment in the upcoming period.
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Copy and paste a formatted citation
Spandidos Publications style
Tănase A, Nemescu D, Popescu R, Carauleanu A, Mogos RA, Luca A and Onofriescu M: Follicle‑stimulating hormone receptor gene polymorphisms of ovarian reserve markers in Romanian population. Exp Ther Med 20: 203, 2020.
APA
Tănase, A., Nemescu, D., Popescu, R., Carauleanu, A., Mogos, R.A., Luca, A., & Onofriescu, M. (2020). Follicle‑stimulating hormone receptor gene polymorphisms of ovarian reserve markers in Romanian population. Experimental and Therapeutic Medicine, 20, 203. https://doi.org/10.3892/etm.2020.9333
MLA
Tănase, A., Nemescu, D., Popescu, R., Carauleanu, A., Mogos, R. A., Luca, A., Onofriescu, M."Follicle‑stimulating hormone receptor gene polymorphisms of ovarian reserve markers in Romanian population". Experimental and Therapeutic Medicine 20.6 (2020): 203.
Chicago
Tănase, A., Nemescu, D., Popescu, R., Carauleanu, A., Mogos, R. A., Luca, A., Onofriescu, M."Follicle‑stimulating hormone receptor gene polymorphisms of ovarian reserve markers in Romanian population". Experimental and Therapeutic Medicine 20, no. 6 (2020): 203. https://doi.org/10.3892/etm.2020.9333
Copy and paste a formatted citation
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Spandidos Publications style
Tănase A, Nemescu D, Popescu R, Carauleanu A, Mogos RA, Luca A and Onofriescu M: Follicle‑stimulating hormone receptor gene polymorphisms of ovarian reserve markers in Romanian population. Exp Ther Med 20: 203, 2020.
APA
Tănase, A., Nemescu, D., Popescu, R., Carauleanu, A., Mogos, R.A., Luca, A., & Onofriescu, M. (2020). Follicle‑stimulating hormone receptor gene polymorphisms of ovarian reserve markers in Romanian population. Experimental and Therapeutic Medicine, 20, 203. https://doi.org/10.3892/etm.2020.9333
MLA
Tănase, A., Nemescu, D., Popescu, R., Carauleanu, A., Mogos, R. A., Luca, A., Onofriescu, M."Follicle‑stimulating hormone receptor gene polymorphisms of ovarian reserve markers in Romanian population". Experimental and Therapeutic Medicine 20.6 (2020): 203.
Chicago
Tănase, A., Nemescu, D., Popescu, R., Carauleanu, A., Mogos, R. A., Luca, A., Onofriescu, M."Follicle‑stimulating hormone receptor gene polymorphisms of ovarian reserve markers in Romanian population". Experimental and Therapeutic Medicine 20, no. 6 (2020): 203. https://doi.org/10.3892/etm.2020.9333
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