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Article

Direct oral anticoagulant treatment of deep vein thrombosis reduces IL‑6 expression in peripheral mono‑nuclear blood cells

  • Authors:
    • Saverio Candido
    • Giovanni Lumera
    • Giuliana Barcellona
    • Davide Vetri
    • Elda Tumino
    • Ingrid Platania
    • Evelise Frazzetto
    • Graziella Privitera
    • Carmela Incognito
    • Agostino Gaudio
    • Salvatore Santo Signorelli
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical and Biotechnological Sciences, Oncologic, Clinic and General Pathology Section, University of Catania, I‑95123 Catania, Italy, Department of Clinical and Experimental Medicine, University of Catania, I‑95123 Catania, Italy, Internal Medicine Division, University Hospital ‘G. Rodolico’, I‑95123 Catania, Italy
  • Article Number: 237
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    Published online on: October 21, 2020
       https://doi.org/10.3892/etm.2020.9367
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Abstract

Multiple factors play a pathophysiologic role for the venous thromboembolism (VTE) as a multi‑factorial disease. Inflammation might play a peculiar role in shifting towards a pro‑thrombotic state. Anticoagulant drugs are the first cure line for VTE. The low‑molecular‑weight heparins (LMWH) show anti‑coagulant capability as well as reducing levels of inflammatory factors, including interleukin (IL)‑6. The direct oral anticoagulants (DOACs) have shown efficacy in threating VTE, additionally to the anti‑activated factor X these drugs seem able to reduce the abnormal release of pro‑inflammatory agents. The present study evaluated the capability of DOACs in reducing plasma level of IL‑6 in patients suffered from deep vein thrombosis (DVT) of the lower limbs. Our results showed reduced IL‑6 expression levels in the peripheral lymphocytes of DVT compared to controls (fold‑change, 2.8; P<0.05). We postulate that lowered IL‑6 expression in the lymphocytes of DVT patients may mediate the anti‑inflammatory action of DOACs. The present study is the first evidence concerning the anti‑inflammatory properties of DOACs in specific setting of VTE patients such as DVT.
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Copy and paste a formatted citation
Spandidos Publications style
Candido S, Lumera G, Barcellona G, Vetri D, Tumino E, Platania I, Frazzetto E, Privitera G, Incognito C, Gaudio A, Gaudio A, et al: Direct oral anticoagulant treatment of deep vein thrombosis reduces IL‑6 expression in peripheral mono‑nuclear blood cells. Exp Ther Med 20: 237, 2020.
APA
Candido, S., Lumera, G., Barcellona, G., Vetri, D., Tumino, E., Platania, I. ... Signorelli, S.S. (2020). Direct oral anticoagulant treatment of deep vein thrombosis reduces IL‑6 expression in peripheral mono‑nuclear blood cells. Experimental and Therapeutic Medicine, 20, 237. https://doi.org/10.3892/etm.2020.9367
MLA
Candido, S., Lumera, G., Barcellona, G., Vetri, D., Tumino, E., Platania, I., Frazzetto, E., Privitera, G., Incognito, C., Gaudio, A., Signorelli, S. S."Direct oral anticoagulant treatment of deep vein thrombosis reduces IL‑6 expression in peripheral mono‑nuclear blood cells". Experimental and Therapeutic Medicine 20.6 (2020): 237.
Chicago
Candido, S., Lumera, G., Barcellona, G., Vetri, D., Tumino, E., Platania, I., Frazzetto, E., Privitera, G., Incognito, C., Gaudio, A., Signorelli, S. S."Direct oral anticoagulant treatment of deep vein thrombosis reduces IL‑6 expression in peripheral mono‑nuclear blood cells". Experimental and Therapeutic Medicine 20, no. 6 (2020): 237. https://doi.org/10.3892/etm.2020.9367
Copy and paste a formatted citation
x
Spandidos Publications style
Candido S, Lumera G, Barcellona G, Vetri D, Tumino E, Platania I, Frazzetto E, Privitera G, Incognito C, Gaudio A, Gaudio A, et al: Direct oral anticoagulant treatment of deep vein thrombosis reduces IL‑6 expression in peripheral mono‑nuclear blood cells. Exp Ther Med 20: 237, 2020.
APA
Candido, S., Lumera, G., Barcellona, G., Vetri, D., Tumino, E., Platania, I. ... Signorelli, S.S. (2020). Direct oral anticoagulant treatment of deep vein thrombosis reduces IL‑6 expression in peripheral mono‑nuclear blood cells. Experimental and Therapeutic Medicine, 20, 237. https://doi.org/10.3892/etm.2020.9367
MLA
Candido, S., Lumera, G., Barcellona, G., Vetri, D., Tumino, E., Platania, I., Frazzetto, E., Privitera, G., Incognito, C., Gaudio, A., Signorelli, S. S."Direct oral anticoagulant treatment of deep vein thrombosis reduces IL‑6 expression in peripheral mono‑nuclear blood cells". Experimental and Therapeutic Medicine 20.6 (2020): 237.
Chicago
Candido, S., Lumera, G., Barcellona, G., Vetri, D., Tumino, E., Platania, I., Frazzetto, E., Privitera, G., Incognito, C., Gaudio, A., Signorelli, S. S."Direct oral anticoagulant treatment of deep vein thrombosis reduces IL‑6 expression in peripheral mono‑nuclear blood cells". Experimental and Therapeutic Medicine 20, no. 6 (2020): 237. https://doi.org/10.3892/etm.2020.9367
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