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Comparison of regulatory networks of E74‑like factor 1 and cold‑shock domain‑containing E1 in breast cancer cell lines using ChIP datasets

  • Authors:
    • Haibo Duan
    • Huafang He
    • Qian Hu
    • Yingxin Lin
    • Shuo Cao
    • Xiaoshan Lan
    • Litao Li
    • Danmei Pang
  • View Affiliations / Copyright

    Affiliations: Department of Breast Cancer Medicine, The First People's Hospital of Foshan, Foshan, Guangdong 528000, P.R. China, Department of Radiotherapy, The First People's Hospital of Foshan, Foshan, Guangdong 528000, P.R. China
    Copyright: © Duan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 245
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    Published online on: October 22, 2020
       https://doi.org/10.3892/etm.2020.9375
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Abstract

In the present study, differences in the expression of target genes between chromatin immunoprecipitation sequencing (ChIP‑seq) datasets of breast cancer MCF‑7 cells treated with antibodies to E74‑like factor 1 (ELF1) and cold‑shock domain‑containing E1 (CSDE1) were analyzed and gene regulatory networks were established. The datasets were downloaded from the Gene Expression Omnibus (GEO) database. ELF1‑associated target genes and CSDE1‑associated target genes were analyzed for functional prediction and protein‑protein interaction (PPI) networks. The ELF1 ChIP‑seq dataset contained 95 ELF1‑associated target genes, while the CSDE1 ChIP‑seq dataset contained 826 CSDE1‑associated target genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated that the ELF1‑ and CSDE1‑associated target genes had different potential functions and signaling pathways. The ELF1‑associated target genes were mainly enriched in the GO terms of molecular transducer activity, catalytic activity, cellular processes and response to sensitivity, and in the KEGG pathways of olfactory transduction, the chemokine signaling pathway, carbohydrate digestion and absorption, and starch and sucrose metabolism. The CSDE1‑associated target genes were mainly enriched in the GO terms of binding, transcription regulator activity, cellular processes and metabolic processes, and in the KEGG pathways of ribosome, metabolic pathways, endocytosis, oxidative phosphorylation and transcriptional misregulation in cancer. PPI network analysis revealed that the ELF1 regulatory network primarily regulated chemokine‑mediated malignant tumor cells, while the CSDE1 regulatory network mainly regulated ribosomes, metabolic pathways and oxidative phosphorylation. Reverse transcription‑quantitative PCR indicated that ELF1 overexpression led to significant downregulation of C‑X‑C motif chemokine‑8 and ‑6 expression levels in MCF‑7 cells, while overexpression of CSDE1 significantly induced the mRNA expression of CSDE1‑associated target genes, which included mitochondrial ribosomal protein L4, NADH: ubiquinone oxidoreductase subunit B7, small nuclear ribonucleoprotein polypeptide E, ribosomal protein S26 (RPS26), RPS11 and RPS6, in the MCF‑7 cells. In breast cancer MCF‑7 cells, the target genes and regulatory pathways of ELF1 and CSDE1 were different. Understanding these regulatory pathways may help to develop strategies for personalized breast cancer treatment.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015.PubMed/NCBI View Article : Google Scholar

2 

Malvezzi M, Carioli G, Bertuccio P, Rosso T, Boffetta P, Levi F, La Vecchia C and Negri E: European cancer mortality predictions for the year 2016 with focus on leukaemias. Ann Oncol. 27:725–731. 2016.PubMed/NCBI View Article : Google Scholar

3 

Gradishar WJ, Anderson BO, Balassanian R, Blair SL, Burstein HJ, Cyr A, Elias AD, Farrar WB, Forero A, Giordano SH, et al: Breast cancer, version 4.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 16:310–320. 2018.PubMed/NCBI View Article : Google Scholar

4 

Chen W, Sun K, Zheng R, Zheng R, Zeng H, Zhang S, Xia C, Yang Z, Li H, Zou X and He J: Cancer incidence and mortality in China, 2014. Chin J Cancer Res. 30:1–12. 2018.PubMed/NCBI View Article : Google Scholar

5 

Brueffer C, Vallon-Christersson J, Grabau D, Ehinger A, Häkkinen J, Hegardt C, Malina J, Chen Y, Bendahl PO, Manjer J, et al: Clinical value of RNA sequencing-based classifiers for prediction of the five conventional breast cancer biomarkers: A report from the population-based multicenter Sweden cancerome analysis network-breast initiative. JCO Precision Oncol. 2:1–18. 2018.PubMed/NCBI View Article : Google Scholar

6 

O'Regan RM and Nahta R: Targeting forkhead box M1 transcription factor in breast cancer. Biochem Pharmacol. 154:407–413. 2018.PubMed/NCBI View Article : Google Scholar

7 

Safe S, Abbruzzese J, Abdelrahim M and Hedrick E: Specificity protein transcription factors and cancer: Opportunities for drug development. Cancer Prev Res (Phila). 11:371–382. 2018.PubMed/NCBI View Article : Google Scholar

8 

Seth A and Watson DK: ETS transcription factors and their emerging roles in human cancer. Eur J Cancer. 41:2462–2478. 2005.PubMed/NCBI View Article : Google Scholar

9 

Andrews PG, Kennedy MW, Popadiuk CM and Kao KR: Oncogenic activation of the human Pygopus2 promoter by E74-like factor-1. Mol Cancer Res. 6:259–266. 2008.PubMed/NCBI View Article : Google Scholar

10 

Lindquist JA and Mertens PR: Cold shock proteins: From cellular mechanisms to pathophysiology and disease. Cell Commun Signal. 16(63)2018.PubMed/NCBI View Article : Google Scholar

11 

Doniger J, Landsman D, Gonda MA and Wistow G: The product of unr, the highly conserved gene upstream of N-ras, contains multiple repeats similar to the cold-shock domain (CSD), a putative DNA-binding motif. New Biol. 4:389–395. 1992.PubMed/NCBI

12 

Wurth L, Papasaikas P, Olmeda D, Bley N, Calvo GT, Guerrero S, Cerezo-Wallis D, Martinez-Useros J, García-Fernández M, Hüttelmaier S, et al: UNR/CSDE1 drives a post-transcriptional program to promote melanoma invasion and metastasis. Cancer Cell. 30:694–707. 2016.PubMed/NCBI View Article : Google Scholar

13 

Arndt S, Unger P, Wacker E, Shimizu T, Heinlin J, Li YF, Thomas HM, Morfill GE, Zimmermann JL, Bosserhoff AK and Karrer S: Cold atmospheric plasma (CAP) changes gene expression of key molecules of the wound healing machinery and improves wound healing in vitro and in vivo. PLoS One. 8(e79325)2013.PubMed/NCBI View Article : Google Scholar

14 

Heidari N, Phanstiel DH, He C, Grubert F, Jahanbani F, Kasowski M, Zhang MQ and Snyder MP: Genome-wide map of regulatory interactions in the human genome. Genome Res. 24:1905–1917. 2014.PubMed/NCBI View Article : Google Scholar

15 

Pan W, Liang J, Tang H, Fang X, Wang F, Ding Y, Huang H and Zhang H: Differentially expressed microRNA profiles in exosomes from vascular smooth muscle cells associated with coronary artery calcification. Int J Biochem Cell Biol. 118(105645)2020.PubMed/NCBI View Article : Google Scholar

16 

Wang J and Knaut H: Chemokine signaling in development and disease. Development. 141:4199–4205. 2014.PubMed/NCBI View Article : Google Scholar

17 

Zlotnik A: Chemokines and cancer. Int J Cancer. 119:2026–2029. 2006.PubMed/NCBI View Article : Google Scholar

18 

Strieter RM, Belperio JA, Phillips RJ and Keane MP: CXC chemokines in angiogenesis of cancer. Semin Cancer Biol. 14:195–200. 2004.PubMed/NCBI View Article : Google Scholar

19 

Atretkhany KN, Drutskaya MS, Nedospasov SA, Grivennikov SI and Kuprash DV: Chemokines, cytokines and exosomes help tumors to shape inflammatory microenvironment. Pharmacol Ther. 168:98–112. 2016.PubMed/NCBI View Article : Google Scholar

20 

Garetto S, Sardi C, Morone D and Kallikourdis M: Chemokines and T cell trafficking into tumors: Strategies to enhance recruitment of T cells into tumors. Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy pp 163-177, 2016.

21 

Moniuszko A, Czupryna P, Pancewicz S, Rutkowski K, Zajkowska O, Swierzbińska R, Grygorczuk S, Kondrusik M, Owłasiuk P and Zajkowska J: Evaluation of CXCL8, CXCL10, CXCL11, CXCL12 and CXCL13 in serum and cerebrospinal fluid of patients with neuroborreliosis. Immunol Lett. 157:45–50. 2014.PubMed/NCBI View Article : Google Scholar

22 

Wang C, Wu K, Yu Q, Zhang S, Gao Z, Liu Y, Ni L, Cheng Y, Guan Z, Shi M, et al: CXCL13, CXCL10 and CXCL8 as potential biomarkers for the diagnosis of neurosyphilis patients. Sci Rep. 6(33569)2016.PubMed/NCBI View Article : Google Scholar

23 

Brysse A, Mestdagt M, Polette M, Luczka E, Hunziker W, Noël A, Birembaut P, Foidart JM and Gilles C: Regulation of CXCL8/IL-8 expression by zonula occludens-1 in human breast cancer cells. Mol Cancer Res. 10:121–132. 2012.PubMed/NCBI View Article : Google Scholar

24 

Azenshtein E, Meshel T, Shina S, Barak N, Keydar I and Ben-Baruch A: The angiogenic factors CXCL8 and VEGF in breast cancer: Regulation by an array of pro-malignancy factors. Cancer Lett. 217:73–86. 2005.PubMed/NCBI View Article : Google Scholar

25 

Li J, Tang Z, Wang H, Wu W, Zhou F, Ke H, Lu W, Zhang S, Zhang Y, Yang S, et al: CXCL6 promotes non-small cell lung cancer cell survival and metastasis via down-regulation of miR-515-5p. Biomed Pharmacother. 97:1182–1188. 2018.PubMed/NCBI View Article : Google Scholar

26 

Tian H, Huang P, Zhao Z, Tang W and Xia J: HIF-1α plays a role in the chemotactic migration of hepatocarcinoma cells through the modulation of CXCL6 expression. Cell Physiol Biochem. 34:1536–1546. 2014.PubMed/NCBI View Article : Google Scholar

27 

Ejaeidi AA, Craft BS, Puneky LV, Lewis RE and Cruse JM: Hormone receptor-independent CXCL10 production is associated with the regulation of cellular factors linked to breast cancer progression and metastasis. Exp Mol Pathol. 99:163–172. 2015.PubMed/NCBI View Article : Google Scholar

28 

Mulligan AM, Raitman I, Feeley L, Pinnaduwage D, Nguyen LT, O'Malley FP, Ohashi PS and Andrulis IL: Tumoral lymphocytic infiltration and expression of the chemokine CXCL10 in breast cancers from the Ontario Familial breast cancer registry. Clin Cancer Res. 19:336–346. 2013.PubMed/NCBI View Article : Google Scholar

29 

Bu H, Shu B, Gao F, Liu C, Guan X, Ke C, Cao F, Hinton AO Jr, Xiang H, Yang H, et al: Spinal IFN-γ-induced protein-10 (CXCL10) mediates metastatic breast cancer-induced bone pain by activation of microglia in rat models. Breast Cancer Res Treat. 143:255–263. 2014.PubMed/NCBI View Article : Google Scholar

30 

Datta D, Flaxenburg JA, Laxmanan S, Geehan C, Grimm M, Waaga-Gasser AM, Briscoe DM and Pal S: Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: Relevance for the development of human breast cancer. Cancer Res. 66:9509–9518. 2006.PubMed/NCBI View Article : Google Scholar

31 

Fernandez-Pol JA: Increased serum level of RPMPS-1/S27 protein in patients with various types of cancer is useful for the early detection, prevention and therapy. Cancer Genomics Proteomics. 9:203–256. 2012.PubMed/NCBI

32 

Zhu Y, Poyurovsky MV, Li Y, Biderman L, Stahl J, Jacq X and Prives C: Ribosomal protein S7 is both a regulator and a substrate of MDM2. Mol Cell. 35:316–326. 2009.PubMed/NCBI View Article : Google Scholar

33 

Wang Z, Cotney J and Shadel GS: Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression. J Biol Chem. 282:12610–12618. 2007.PubMed/NCBI View Article : Google Scholar

34 

Miller C, Saada A, Shaul N, Shabtai N, Ben-Shalom E, Shaag A, Hershkovitz E and Elpeleg O: Defective mitochondrial translation caused by a ribosomal protein (MRPS16) mutation. Ann Neurol. 56:734–738. 2004.PubMed/NCBI View Article : Google Scholar

35 

Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, Palacios OM, Montier L, Bai Y, Tong Q and Koc EC: NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10. J Biol Chem. 285:7417–7429. 2010.PubMed/NCBI View Article : Google Scholar

36 

Yoo YA, Kim MJ, Park JK, Chung YM, Lee JH, Chi SG, Kim JS and Yoo YD: Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1. Mol Cell Biol. 25:6603–6616. 2005.PubMed/NCBI View Article : Google Scholar

37 

Anchi T, Tamura K, Furihata M, Satake H, Sakoda H, Kawada C, Kamei M, Shimamoto T, Fukuhara H, Fukata S, et al: SNRPE is involved in cell proliferation and progression of high-grade prostate cancer through the regulation of androgen receptor expression. Oncol Lett. 3:264–268. 2012.PubMed/NCBI View Article : Google Scholar

38 

Yong WH, Shabihkhani M, Telesca D, Yang S, Tso JL, Menjivar JC, Wei B, Lucey GM, Mareninov S, Chen Z, et al: Ribosomal proteins RPS11 and RPS20, two stress-response markers of glioblastoma stem cells, are novel predictors of poor prognosis in glioblastoma patients. PLoS One. 10(e0141334)2015.PubMed/NCBI View Article : Google Scholar

39 

Calvisi DF, Wang C, Ho C, Ladu S, Lee SA, Mattu S, Destefanis G, Delogu S, Zimmermann A, Ericsson J, et al: Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Gastroenterology. 140:1071–1083. 2011.PubMed/NCBI View Article : Google Scholar

40 

Li G, Shan C, Liu L, Zhou T, Zhou J, Hu X, Chen Y, Cui H and Gao N: Tanshinone IIA inhibits HIF-1α and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway. PLoS One. 10(e0117440)2015.PubMed/NCBI View Article : Google Scholar

41 

Wang C, Cigliano A, Jiang L, Li X, Fan B, Pilo MG, Liu Y, Gui B, Sini M, Smith JW, et al: 4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice. Hepatology. 61:200–213. 2015.PubMed/NCBI View Article : Google Scholar

42 

Smeitink J and van den Heuvel L: Human mitochondrial complex I in health and disease. Am J Hum Genet. 64:1505–1510. 1999.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Duan H, He H, Hu Q, Lin Y, Cao S, Lan X, Li L and Pang D: Comparison of regulatory networks of E74‑like factor 1 and cold‑shock domain‑containing E1 in breast cancer cell lines using ChIP datasets. Exp Ther Med 20: 245, 2020.
APA
Duan, H., He, H., Hu, Q., Lin, Y., Cao, S., Lan, X. ... Pang, D. (2020). Comparison of regulatory networks of E74‑like factor 1 and cold‑shock domain‑containing E1 in breast cancer cell lines using ChIP datasets. Experimental and Therapeutic Medicine, 20, 245. https://doi.org/10.3892/etm.2020.9375
MLA
Duan, H., He, H., Hu, Q., Lin, Y., Cao, S., Lan, X., Li, L., Pang, D."Comparison of regulatory networks of E74‑like factor 1 and cold‑shock domain‑containing E1 in breast cancer cell lines using ChIP datasets". Experimental and Therapeutic Medicine 20.6 (2020): 245.
Chicago
Duan, H., He, H., Hu, Q., Lin, Y., Cao, S., Lan, X., Li, L., Pang, D."Comparison of regulatory networks of E74‑like factor 1 and cold‑shock domain‑containing E1 in breast cancer cell lines using ChIP datasets". Experimental and Therapeutic Medicine 20, no. 6 (2020): 245. https://doi.org/10.3892/etm.2020.9375
Copy and paste a formatted citation
x
Spandidos Publications style
Duan H, He H, Hu Q, Lin Y, Cao S, Lan X, Li L and Pang D: Comparison of regulatory networks of E74‑like factor 1 and cold‑shock domain‑containing E1 in breast cancer cell lines using ChIP datasets. Exp Ther Med 20: 245, 2020.
APA
Duan, H., He, H., Hu, Q., Lin, Y., Cao, S., Lan, X. ... Pang, D. (2020). Comparison of regulatory networks of E74‑like factor 1 and cold‑shock domain‑containing E1 in breast cancer cell lines using ChIP datasets. Experimental and Therapeutic Medicine, 20, 245. https://doi.org/10.3892/etm.2020.9375
MLA
Duan, H., He, H., Hu, Q., Lin, Y., Cao, S., Lan, X., Li, L., Pang, D."Comparison of regulatory networks of E74‑like factor 1 and cold‑shock domain‑containing E1 in breast cancer cell lines using ChIP datasets". Experimental and Therapeutic Medicine 20.6 (2020): 245.
Chicago
Duan, H., He, H., Hu, Q., Lin, Y., Cao, S., Lan, X., Li, L., Pang, D."Comparison of regulatory networks of E74‑like factor 1 and cold‑shock domain‑containing E1 in breast cancer cell lines using ChIP datasets". Experimental and Therapeutic Medicine 20, no. 6 (2020): 245. https://doi.org/10.3892/etm.2020.9375
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