|
1
|
Renda G, Yalçın FN, Nemutlu E, Akkol EK,
Süntar İ, Keleş H, Ina H, Çalış İ and Ersöz T: Comparative
assessment of dermal wound healing potentials of various Trifolium
L. Extracts and determination of their isoflavone contents as
potential active ingredients. J Ethnopharmacol. 148:423–432.
2013.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Srinivas NR: Biochanin A: Understanding
the complexities in the paradoxical drug-drug interaction
potential. Eur J Drug Metab Pharmacokinet. 40:119–125.
2015.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Puthli A, Tiwari R and Mishra KP:
Biochanin a enhances the radiotoxicity in colon tumor cells in
vitro. J Environ Pathol Toxicol Oncol. 32:189–203. 2013.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Su SJ, Yeh YT and Shyu HW: The preventive
effect of biochanin a on bone loss in ovariectomized rats:
Involvement in regulation of growth and activity of osteoblasts and
osteoclasts. Evid Based Complement Alternat Med.
2013(594857)2013.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Chen HQ, Jin ZY and Li GH: Biochanin A
protects dopaminergic neurons against lipopolysaccharide-induced
damage through inhibition of microglia activation and
proinflammatory factors generation. Neurosci Lett. 417:112–117.
2007.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Kole L, Giri B, Manna SK, Pal B and Ghosh
S: Biochanin-A, an isoflavon, showed anti-proliferative and
anti-inflammatory activities through the inhibition of iNOS
expression, p38-MAPK and ATF-2 phosphorylation and blocking NFκB
nuclear translocation. Eur J Pharmacol. 653:8–15. 2011.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Ming X, Ding M, Zhai B, Xiao L, Piao T and
Liu M: Biochanin A inhibits lipopolysaccharide-induced inflammation
in human umbilical vein endothelial cells. Life Sci. 136:36–41.
2015.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Lee KH and Choi EM: Biochanin A stimulates
osteoblastic differentiation and inhibits hydrogen peroxide-induced
production of inflammatory mediators in MC3T3-E1 cells. Biol Pharm
Bull. 28:1948–1953. 2005.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Oh JS, Cho IA, Kang KR, You JS, Yu SJ, Lee
GJ, Seo YS, Kim CS, Kim DK, Kim G, et al: Biochanin-A antagonizes
the interleukin-1β-induced catabolic inflammation through the
modulation of NFκB cellular signaling in primary rat chondrocytes.
Biochem Biophys Res Commun. 477:723–730. 2016.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Vanden Berghe W, Dijsselbloem N, Vermeulen
L, Ndlovu MN, Boone E and Haegeman G: Attenuation of mitogen- and
stress-activated protein kinase-1-driven nuclear factor-kappaB gene
expression by soy isoflavones does not require estrogenic activity.
Cancer Res. 66:4852–4862. 2006.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Wu LY, Ye ZN, Zhuang Z, Gao Y, Tang C,
Zhou CH, Wang CX, Zhang XS, Xie GB, Liu JP, et al: Biochanin A
Reduces inflammatory injury and neuronal apoptosis following
subarachnoid hemorrhage via suppression of the
TLRs/TIRAP/MyD88/NF-κB pathway. Behavioural Neurology. 2018:1–10.
2018.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Xue Z, Zhang Q, Yu W, Wen H, Hou X, Li D
and Kou X: Potential lipid-lowering mechanisms of biochanin A. J
Agric Food Chem. 65:3842–3850. 2017.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Ko WC, Lin LH, Shen HY, Lai CY, Chen CM
and Shih CH: Biochanin a, a phytoestrogenic isoflavone with
selective inhibition of phosphodiesterase 4, suppresses
ovalbumin-induced airway hyperresponsiveness. Evid Based Complement
Alternat Med. 2011(635058)2011.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Beck V, Rohr U and Jungbauer A:
Phytoestrogens derived from red clover: An alternative to estrogen
replacement therapy? J Steroid Biochem Mol Biol. 94:499–518.
2005.PubMed/NCBI View Article : Google Scholar
|
|
15
|
GBD 2016 Disease and Injury Incidence and
Prevalence Collaborators: Global, regional, and national incidence,
prevalence, and years lived with disability for 328 diseases and
injuries for 195 countries, 1990-2016: A systematic analysis for
the Global Burden of Disease Study 2016. Lancet 390: 1211-1259,
2017.
|
|
16
|
Darveau RP: Periodontitis: A polymicrobial
disruption of host homeostasis. Nat Rev Microbiol. 8:481–490.
2010.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Liu C, Mo L, Niu Y, Li X, Zhou X and Xu X:
The role of reactive oxygen species and autophagy in periodontitis
and their potential linkage. Front Physiol. 8(439)2017.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Hanazawa S, Nakada K, Ohmori Y, Miyoshi T,
Amano S and Kitano S: Functional role of interleukin 1 in
periodontal disease: Induction of interleukin 1 production by
Bacteroides gingivalis lipopolysaccharide in peritoneal macrophages
from C3H/HeN and C3H/HeJ mice. Infect Immun. 50:262–270.
1985.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Nibali L and Donos N: Periodontitis and
redox status: A review. Curr Pharm Des. 19:2687–2697.
2013.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Chapple IL and Matthews JB: The role of
reactive oxygen and antioxidant species in periodontal tissue
destruction. Periodontol. 43:160–232. 2010.
|
|
21
|
Dursun E, Akalin FA, Genc T, Cinar N, Erel
O and Yildiz BO: Oxidative stress and periodontal disease in
obesity. Medicine (Baltimore). 95(e3136)2016.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Soares ASLS, Scelza MZ, Spoladore J,
Gallito MA, Oliveira F, Moraes RCM and Alves GG: Comparison of
primary human gingival fibroblasts from an older and a young donor
on the evaluation of cytotoxicity of denture adhesives. J Appl Oral
Sci. 26(e20160594)2018.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Chen H, Shi Q, Qing Y, Yao YC and Cao YG:
Cytotoxicity of modified nonequilibrium plasma with chlorhexidine
digluconate on primary cultured human gingival fibroblasts. J
Huazhong Univ Sci Technolog Med Sci. 36:137–141. 2016.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Wu DQ, Zhong HM, Ding QH and Ba L:
Protective effects of biochanin A on articular cartilage: In vitro
and in vivo studies. BMC Complement Altern Med.
14(444)2014.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Abe T and Hajishengallis G: Optimization
of the ligature-induced periodontitis model in mice. J Immunol
Methods. 394:49–54. 2013.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Bhattarai G, Kook SH, Kim JH, Poudel SB,
Lim SS, Seo YK and Lee JC: COMP-Ang1 prevents periodontitic damages
and enhances mandible bone growth in an experimental animal model.
Bone. 92:168–179. 2016.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Papathanasiou E, Kantarci A,
Konstantinidis A, Gao H and Van Dyke TE: SOCS-3 regulates alveolar
bone loss in experimental periodontitis. J Dent Res. 95:1018–1025.
2016.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Li CH and Amar S: Morphometric,
histomorphometric, and microcomputed tomographic analysis of
periodontal inflammatory lesions in a murine model. J Periodontol.
78:1120–1128. 2007.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Dumitrescu AL, Abd-El-Aleem S, Morales-Aza
B and Donaldson LF: A model of periodontitis in the rat: Effect of
lipopolysaccharide on bone resorption, osteoclast activity, and
local peptidergic innervation. J Clin Periodontol. 31:596–603.
2004.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Lawrence CB, Brough D and Knight EM: Obese
mice exhibit an altered behavioural and inflammatory response to
lipopolysaccharide. Dis Model Mech. 5:649–659. 2012.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Rettori E, De Laurentiis A, Zorrilla
Zubilete M, Rettori V and Elverdin JC: Anti-inflammatory effect of
the endocannabinoid anandamide in experimental periodontitis and
stress in the rat. Neuroimmunomodulation. 19:293–303.
2012.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Wang J, He C, Wu WY, Chen F, Wu YY, Li WZ,
Chen HQ and Yin YY: Biochanin A protects dopaminergic neurons
against lipopolysaccharide-induced damage and oxidative stress in a
rat model of Parkinson's disease. Pharmacol Biochem Behav.
138:96–103. 2015.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Luo Q, Shi X, Ding J, Ma Z, Chen X, Leng
Y, Zhang X and Liu Y: Network pharmacology integrated molecular
docking reveals the antiosteosarcoma mechanism of biochanin A. Evid
Based Complement Alternat Med. 2019(1410495)2019.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Nestel P, Cehun M, Chronopoulos A, DaSilva
L, Teede H and McGrath B: A biochanin-enriched isoflavone from red
clover lowers LDL cholesterol in men. Eur J Clin Nutr. 58:403–408.
2004.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Tanaka Y, Nakayamada S and Okada Y:
Osteoblasts and osteoclasts in bone remodeling and inflammation.
Curr Drug Targets Inflamm Allergy. 4:325–328. 2005.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Brock GR, Butterworth CJ, Matthews JB and
Chapple IL: Local and systemic total antioxidant capacity in
periodontitis and health. J Clin Periodontol. 31:515–521. 2010.
|
|
38
|
Liu Q, Hu Y, Cao Y, Song G, Liu Z and Liu
X: Chicoric acid ameliorates lipopolysaccharide-induced oxidative
stress via promoting the Keap1/Nrf2 transcriptional signaling
pathway in BV-2 microglial cells and mouse brain. J Agric Food
Chem. 65:338–347. 2017.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Liang F, Cao W, Huang Y, Fang Y, Cheng Y,
Pan S and Xu X: Isoflavone biochanin A, a novel nuclear factor
erythroid 2-related factor 2 (Nrf2)-antioxidant response element
activator, protects against oxidative damage in HepG2 cells.
Biofactors. 45:563–574. 2019.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Wang J, Wu WY, Huang H, Li WZ, Chen HQ and
Yin YY: Biochanin a protects against lipopolysaccharide-induced
damage of dopaminergic neurons both in vivo and in vitro via
inhibition of microglial activation. Neurotox Res. 30:486–498.
2016.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Liu X, Wang T, Liu X, Cai L, Qi J, Zhang P
and Li Y: Biochanin A protects
lipopolysaccharide/D-galactosamine-induced acute liver injury in
mice by activating the Nrf2 pathway and inhibiting NLRP3
inflammasome activation. Int Immunopharmacol. 38:324–331.
2016.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Kim J, Cha YN and Surh YJ: A protective
role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in
inflammatory disorders. Mutat Res. 690:12–23. 2010.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Bostanci N, Abe T, Belibasakis GN and
Hajishengallis G: TREM-1 Is upregulated in experimental
periodontitis, and its blockade inhibits IL-17A and RANKL
expression and suppresses bone loss. J Clin Med.
8(1579)2019.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Hienz SA, Sweta P and Saso I: Mechanisms
of bone resorption in periodontitis. J Immunol Res.
2015(615486)2015.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Teitelbaum SL: Bone resorption by
osteoclasts. Science. 289:1504–1508. 2000.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Feng W, Guo J and Li M: RANKL-independent
modulation of osteoclastogenesis. J Oral Biosci. 61:16–21.
2019.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Sağlam M, Köseoğlu S, Hatipoğlu M, Esen HH
and Köksal E: Effect of sumac extract on serum oxidative status,
RANKL/OPG system and alveolar bone loss in experimental
periodontitis in rats. J Appl Oral Sci. 23:33–41. 2015.PubMed/NCBI View Article : Google Scholar
|
