Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2020 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2020 Volume 20 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.xlsx
Article Open Access

Tear proteomics of orbital decompression for disfiguring exophthalmos in inactive thyroid‑associated ophthalmopathy

  • Authors:
    • Lihong Jiang
    • Ao Rong
    • Ruili Wei
    • Jiale Diao
    • Hui Ding
    • Wei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, P.R. China, Department of Ophthalmology, Changzheng Hospital, Naval Medicine University, Shanghai 200003, P.R. China, Department of Ophthalmology, Zhabei Central Hospital, Jingan District, Shanghai 200070, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 253
    |
    Published online on: October 23, 2020
       https://doi.org/10.3892/etm.2020.9383
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The progress and achievements that have been made in tear proteomics in thyroid‑associated ophthalmopathy (TAO) are critical for exploring the pathogenesis of TAO and investigating potential therapeutic targets. However, the tear proteomics of orbital decompression for disfiguring exophthalmos in inactive TAO have yet to be properly investigated. In the present study, orbital decompression was performed to repair disfiguring exophthalmos in patients with inactive TAO. Tears were collected before and after orbital decompression in patients with inactive TAO. Liquid chromatography with tandem mass spectrometry (LC‑MS/MS) was performed to explore the changes in tear proteomics. Bioinformatics analyses were then employed to analyze the functions of the differentially expressed proteins (DEPs) identified by LC‑MS/MS. The palpebral fissure height and exophthalmia area were significantly restored after 1 month of orbital decompression such that they approached the normal levels identified in healthy eyeballs. Among the 669 proteins identified by LC‑MS/MS, 83 proteins were changed significantly between the preoperative and postoperative stages in inactive TAO patients and healthy control individuals. The DEPs were predicted to be involved in numerous signaling pathways. Bioinformatics analyses revealed that pathways associated with the immune system, metabolism, programmed cell death, vesicle‑mediated transport, neuronal system and extracellular matrix organization may fulfill significant roles in orbital decompression in patients with inactive TAO. Taken together, these results provided a preliminary understanding of the mechanism of orbital decompression for disfiguring exophthalmos in inactive TAO patients.
View Figures
View References

1 

Nishida Y, Tian S, Isberg B, Hayashi O, Tallstedt L and Lennerstrand G: Significance of orbital fatty tissue for exophthalmos in thyroid-associated ophthalmopathy. Graefes Arch Clin Exp Ophthalmol. 240:515–520. 2002.PubMed/NCBI View Article : Google Scholar

2 

Higashiyama T, Nishida Y and Ohji M: Changes of orbital tissue volumes and proptosis in patients with thyroid extraocular muscle swelling after methylprednisolone pulse therapy. Jpn J Ophthalmol. 59:430–435. 2015.PubMed/NCBI View Article : Google Scholar

3 

Ohtsuka K, Sato A, Kawaguchi S, Hashimoto M and Suzuki Y: Effect of high-dose intravenous steroid pulse therapy followed by 3-month oral steroid therapy for Graves' ophthalmopathy. Jpn J Ophthalmol. 46:563–567. 2002.PubMed/NCBI View Article : Google Scholar

4 

Prat MC, Braunstein AL, Dagi Glass LR and Kazim M: Orbital fat decompression for thyroid eye disease: Retrospective case review and criteria for optimal case selection. Ophthalmic Plast Reconstr Surg. 31:215–218. 2015.PubMed/NCBI View Article : Google Scholar

5 

Krönlein RU: Zur Pathologie und operativen behandlung der dermoidcysten der Orbita. Beitr Klin Chir. 4:149–163. 1889.

6 

Zhang-Nunes SX, Dang S, Garneau HC, Garneau HC, Hwang C, Isaacs D, Chang SH and Goldberg R: Characterization and outcomes of repeat orbital decompression for thyroid-associated orbitopathy. Orbit. 34:57–65. 2015.PubMed/NCBI View Article : Google Scholar

7 

Bahn RS: Is orbital decompression a safe and effective treatment for Graves' orbitopathy? Nat Clin Pract Endocrinol Metab. 3:796–797. 2007.PubMed/NCBI View Article : Google Scholar

8 

Boboridis KG, Uddin J, Mikropoulos DG, Bunce C, Mangouritsas G, Voudouragkaki IC and Konstas AG: Critical appraisal on orbital decompression for thyroid eye disease: A systematic review and literature search. Adv Ther. 32:595–611. 2015.PubMed/NCBI View Article : Google Scholar

9 

Bahn RS and Heufelder AE: Pathogenesis of Graves' ophthalmopathy. N Engl J Med. 329:1468–1475. 1993.

10 

Lim SL, Lim AK, Mumtaz M, Hussein E, Wan Bebakar WM and Khir AS: Prevalence, risk factors, and clinical features of thyroid-associated ophthalmopathy in multiethnic Malaysian patients with Graves' disease. Thyroid. 18:1297–1301. 2008.PubMed/NCBI View Article : Google Scholar

11 

Herbaut A, Liang H, Denoyer A, Baudouin C and Labbé A: Tear film analysis and evaluation of optical quality: A review of the literature (French translation of the article). J Fr Ophtalmol. 42:226–243. 2019.(In French). PubMed/NCBI View Article : Google Scholar

12 

Zhou L and Beuerman RW: The power of tears: How tear proteomics research could revolutionize the clinic. Expert Rev Proteomics. 14:189–191. 2017.PubMed/NCBI View Article : Google Scholar

13 

Janssen PT and van Bijsterveld OP: Origin and biosynthesis of human tear fluid proteins. Invest Ophthalmol Vis. 24:623–630. 1983.PubMed/NCBI

14 

Tsai PS, Evans JE, Green KM, Sullivan RM, Schaumberg DA, Richards SM, Dana MR and Sullivan DA: Proteomic analysis of human meibomian gland secretions. Br J Ophthalmol. 90:372–377. 2006.PubMed/NCBI View Article : Google Scholar

15 

Ji YW, Lee JL, Kang HG, Gu N, Byun H, Yeo A, Noh H, Kim S, Choi EY, Song JS and Lee HK: Corneal lymphangiogenesis facilitates ocular surface inflammation and cell trafficking in dry eye disease. Ocul Surf. 16:306–313. 2018.PubMed/NCBI View Article : Google Scholar

16 

Kishazi E, Dor M, Eperon S, Oberic A, Hamedani M and Turck N: Thyroid-associated orbitopathy and tears: A proteomics study. J Proteomics. 170:110–116. 2018.PubMed/NCBI View Article : Google Scholar

17 

Aass C, Norheim I, Eriksen EF, Børnick EC, Thorsby PM and Pepaj M: Comparative proteomic analysis of tear fluid in Graves' disease with and without orbitopathy. Clin Endocrinol (Oxf). 85:805–812. 2016.PubMed/NCBI View Article : Google Scholar

18 

Choi W, Li Y, Ji YS and Yoon KC: Oxidative stress markers in tears of patients with Graves' orbitopathy and their correlation with clinical activity score. BMC Ophthalmol. 18(303)2018.PubMed/NCBI View Article : Google Scholar

19 

Edina K, Marianne D, Simone E, Oberic A, Turck N and Hamedani M: Differential profiling of lacrimal cytokines in patients suffering from thyroid-associated orbitopathy. Sci Rep. 8(10792)2018.PubMed/NCBI View Article : Google Scholar

20 

Matheis N, Grus FH, Breitenfeld M, Knych I, Funke S, Pitz S, Ponto KA, Pfeiffer N and Kahaly GJ: Proteomics differentiate between thyroid-associated orbitopathy and dry eye syndrome. Invest Opth Vis Sci. 56:2649–2656. 2015.PubMed/NCBI View Article : Google Scholar

21 

Chng CL, Seah LL, Yang M, Shen SY, Koh SK, Gao Y, Deng L, Tong L, Beuerman RW and Zhou L: Proteins calcium binding protein A4 (S100A4) and prolactin induced protein (PIP) are potential biomarkers for thyroid eye disease. Sci Rep. 8(16936)2018.PubMed/NCBI View Article : Google Scholar

22 

Yang M, Chung Y, Lang S, Yawata N, Seah LL and Looi A: The tear cytokine profile in patients with active Graves' orbitopathy. Endocrine. 59:402–409. 2018.PubMed/NCBI View Article : Google Scholar

23 

Ji Y, Qian Z, Dong Y, Zhou H and Fan X: Quantitative morphometry of the orbit in Chinese adults based on a three-dimensional reconstruction method. J Anat. 217:501–506. 2010.PubMed/NCBI View Article : Google Scholar

24 

Schiffman RM, Christianson MD, Jacobsen G, Hirsch JD and Reis BL: Reliability and validity of the ocular surface disease index. Arch Ophthalmol. 118:615–621. 2000.PubMed/NCBI View Article : Google Scholar

25 

Jiang L and Wei R: Analysis of Graves' ophthalmopathy patients' tear protein spectrum. Chin Med J (Engl). 126:4493–4498. 2013.PubMed/NCBI

26 

Breuer K, Foroushani AK, Laird MR, Chen C, Sribnaia A, Lo R, Winsor GL, Hancock RE, Brinkman FS and Lynn DJ: InnateDB: Systems biology of innate immunity and beyond-recent updates and continuing curation. Nucleic Acids Res. 41 (Database Issue):D1228–D1233. 2013.PubMed/NCBI View Article : Google Scholar

27 

Jassal B, Matthews L, Viteri G, Gong C, Lorente P, Fabregat A, Sidiropoulos K, Cook J, Gillespie M, Haw R, et al: The reactome pathway knowledgebase. Nucleic Acids Res. 48 (D1):D498–D503. 2020.PubMed/NCBI View Article : Google Scholar

28 

Haynes W: Benjamini-Hochberg Method. In: Dubitzky W, Wolkenhauer O, Cho KH and Yokota H (eds). Encyclopedia of Systems Biology. Springer, New York, NY, 2013.

29 

Bautista EL: Inflammation, endothelial dysfunction, and the risk of high blood pressure: Epidemiologic and biological evidence. J Hum Hypertens. 17:223–230. 2003.PubMed/NCBI View Article : Google Scholar

30 

Haefliger IO, Von Arx G and Pimentel AR: Pathophysiology of intraocular pressure increase and glaucoma prevalence in thyroid eye disease: A mini-review. Klin Monbl Augenheilkd. 227:292–293. 2010.PubMed/NCBI View Article : Google Scholar

31 

Klein R, Klein BE, Knudtson MD, Wong TY and Tsai MY: Are inflammatory factors related to retinal vessel caliber? The beaver dam eye study. Arch Ophthalmol. 124:87–94. 2006.PubMed/NCBI View Article : Google Scholar

32 

Wall JR, Bernard N, Boucher A, Salvi M, Zhang ZG, Kennerdell J, Tyutyunikov A and Genovese C: Pathogenesis of thyroid-associated ophthalmopathy: An autoimmune disorder of the eye muscle associated with Graves' hyperthyroidism and Hashimoto's thyroiditis. Clin Immunol Immunopathol. 68:1–8. 1993.PubMed/NCBI View Article : Google Scholar

33 

Hwang CJ, Afifiyan N, Sand D, Naik V, Said J, Pollock SJ, Chen B, Phipps RP, Goldberg RA, Smith TJ and Douglas RS: Orbital fibroblasts from patients with thyroid-associated ophthalmopathy overexpress CD40: CD154 hyperinduces IL-6, IL-8, and MCP-1. Invest Ophthalmol Vis Sci. 50:2262–2268. 2009.PubMed/NCBI View Article : Google Scholar

34 

Hiromatsu Y, Yang D, Bednarczuk T, Miyake I, Nonaka K and Inoue Y: Cytokine profiles in eye muscle tissue and orbital fat tissue from patients with thyroid-associated ophthalmopathy. J Clin Endocrinol Metab. 85:1194–1199. 2000.PubMed/NCBI View Article : Google Scholar

35 

Wahrenberg H, Wennlund A and Hoffstedt J: Increased adipose tissue secretion of interleukin-6, but not of leptin, plasminogen activator inhibitor-1 or tumour necrosis factor alpha, in Graves' hyperthyroidism. Eur J Endocrinol. 146:607–611. 2002.PubMed/NCBI View Article : Google Scholar

36 

Kaback LA and Smith TJ: Expression of hyaluronan synthase messenger ribonucleic acids and their induction by interleukin-1beta in human orbital fibroblasts: Potential insight into the molecular pathogenesis of thyroid-associated ophthalmopathy. J Clin Endocrinol Metab. 84:4079–4084. 1999.PubMed/NCBI View Article : Google Scholar

37 

Khong JJ, McNab AA, Ebeling PR, Craig JE and Selva D: Pathogenesis of thyroid eye disease: Review and update on molecular mechanisms. Br J Ophthalmol. 100:142–150. 2016.PubMed/NCBI View Article : Google Scholar

38 

Ma R, Ren H, Xu B, Cheng Y, Gan L, Zhang R, Wu J and Qian J: PH20 inhibits TGFβ1-induced differentiation of perimysial orbital fibroblasts via hyaluronan-CD44 pathway in thyroid-associated ophthalmopathy. Invest Ophthalmol Vis Sci. 60:1431–1441. 2019.PubMed/NCBI View Article : Google Scholar

39 

Areschoug T and Gordon S: Scavenger receptors: Role in innate immunity and microbial pathogenesis. Cell Microbiol. 11:1160–1169. 2009.PubMed/NCBI View Article : Google Scholar

40 

Anderson CK and Miller OF III: Triad of exophthalmos, pretibial myxedema, and acropachy in a patient with Graves' disease. J Am Acad Dermatol. 48:970–972. 2003.PubMed/NCBI View Article : Google Scholar

41 

Esteban JA: AMPA receptor trafficking: A road map for synaptic plasticity. Mol Interv. 3:375–385. 2003.PubMed/NCBI View Article : Google Scholar

42 

Fowler JH, Mccracken E, Dewar D and McCulloch J: Intracerebral injection of AMPA causes axonal damage in vivo. Brain Res. 991:104–112. 2003.PubMed/NCBI View Article : Google Scholar

43 

Nellgård B and Wieloch T: Postischemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischemia. J Cereb Blood Flow Metab. 12:2–11. 1992.PubMed/NCBI View Article : Google Scholar

44 

Wu LQ, Mou P, Chen ZY, Cheng JW, Le QH Cai JP and Wei RL: Altered corneal nerves in chinese thyroid-associated ophthalmopathy patients observed by in vivo confocal microscopy. Med Sci Monit. 25:1024–1031. 2019.PubMed/NCBI View Article : Google Scholar

45 

Koga M, Hiromatsu Y, Jimi A, Inoue Y and Nonaka K: Possible involvement of Fas-mediated apoptosis in eye muscle tissue from patients with thyroid-associated ophthalmopathy. Thyroid. 8:311–318. 1998.PubMed/NCBI View Article : Google Scholar

46 

Zoukhri D, Fix A, Alroy J and Kublin CL: Mechanisms of murine lacrimal gland repair after experimentally induced inflammation. Invest Ophthalmol Vis Sci. 49:4399–4406. 2008.PubMed/NCBI View Article : Google Scholar

47 

Humphreys-Beher MG, Peck AB, Dang H and Talal N: The role of apoptosis in the initiation of the autoimmune response in Sjögren's syndrome. Clin Exp Immunol. 116:383–387. 1999.PubMed/NCBI View Article : Google Scholar

48 

Zoukhri D: Mechanisms involved in injury and repair of the murine lacrimal gland: Role of programmed cell death and mesenchymal stem cells. Ocul Surf. 8:60–69. 2010.PubMed/NCBI View Article : Google Scholar

49 

Smith TJ, Kahaly GJ, Ezra DG, Fleming JC, Dailey RA, Tang RA, Harris GJ, Antonelli A, Salvi M, Goldberg RA, et al: Teprotumumab for thyroid-associated ophthalmopathy. N Engl J Med. 376:1748–1761. 2017.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jiang L, Rong A, Wei R, Diao J, Ding H and Wang W: Tear proteomics of orbital decompression for disfiguring exophthalmos in inactive thyroid‑associated ophthalmopathy. Exp Ther Med 20: 253, 2020.
APA
Jiang, L., Rong, A., Wei, R., Diao, J., Ding, H., & Wang, W. (2020). Tear proteomics of orbital decompression for disfiguring exophthalmos in inactive thyroid‑associated ophthalmopathy. Experimental and Therapeutic Medicine, 20, 253. https://doi.org/10.3892/etm.2020.9383
MLA
Jiang, L., Rong, A., Wei, R., Diao, J., Ding, H., Wang, W."Tear proteomics of orbital decompression for disfiguring exophthalmos in inactive thyroid‑associated ophthalmopathy". Experimental and Therapeutic Medicine 20.6 (2020): 253.
Chicago
Jiang, L., Rong, A., Wei, R., Diao, J., Ding, H., Wang, W."Tear proteomics of orbital decompression for disfiguring exophthalmos in inactive thyroid‑associated ophthalmopathy". Experimental and Therapeutic Medicine 20, no. 6 (2020): 253. https://doi.org/10.3892/etm.2020.9383
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang L, Rong A, Wei R, Diao J, Ding H and Wang W: Tear proteomics of orbital decompression for disfiguring exophthalmos in inactive thyroid‑associated ophthalmopathy. Exp Ther Med 20: 253, 2020.
APA
Jiang, L., Rong, A., Wei, R., Diao, J., Ding, H., & Wang, W. (2020). Tear proteomics of orbital decompression for disfiguring exophthalmos in inactive thyroid‑associated ophthalmopathy. Experimental and Therapeutic Medicine, 20, 253. https://doi.org/10.3892/etm.2020.9383
MLA
Jiang, L., Rong, A., Wei, R., Diao, J., Ding, H., Wang, W."Tear proteomics of orbital decompression for disfiguring exophthalmos in inactive thyroid‑associated ophthalmopathy". Experimental and Therapeutic Medicine 20.6 (2020): 253.
Chicago
Jiang, L., Rong, A., Wei, R., Diao, J., Ding, H., Wang, W."Tear proteomics of orbital decompression for disfiguring exophthalmos in inactive thyroid‑associated ophthalmopathy". Experimental and Therapeutic Medicine 20, no. 6 (2020): 253. https://doi.org/10.3892/etm.2020.9383
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team