Clinical characteristics of 78&nbsp;cases of patients infected with coronavirus disease 2019 in Wuhan, China

Lin,Liying; Zhong,Canmei; Rao,Shanshan; Lin,Hongguang; Huang,Rongfeng; Chen,Fenglin

doi:10.3892/etm.2020.9439

Clinical characteristics of 78 cases of patients infected with coronavirus disease 2019 in Wuhan, China

Authors:
- Liying Lin
- Canmei Zhong
- Shanshan Rao
- Hongguang Lin
- Rongfeng Huang
- Fenglin Chen
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Affiliations: Department of Gastroenterology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350000, P.R. China, Department of Critical Care Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian 350000, P.R. China, Department of Respiratory Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian 350000, P.R. China
Published online on: November 4, 2020 https://doi.org/10.3892/etm.2020.9439
Article Number: 7
Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Coronavirus disease 2019 (COVID‑19) emerged in Wuhan and rapidly spread throughout the world in December 2019. The present study aimed to describe the clinical characteristics and laboratory findings of 78 patients with COVID‑19 in order to enhance the understanding of the disease. Medical records and data of 78 patients with COVID‑19, including demographics, clinical features, laboratory findings and radiological characteristics, were collected and analyzed. Of the 78 hospitalized patients with COVID‑19, the median age was 66.5 years and 48.7% of patients were male. Hypertension and diabetes were the most common chronic underlying diseases, and the most common symptoms were a cough and a fever. Furthermore, the most common findings on the chest CT were extensive ground‑glass opacity and bilateral shadowing. Anemia and lymphocytopenia were the most common abnormalities identified during routine blood tests. COVID‑19 caused early liver renal damage, with 52.9% of patients displaying elevated D‑dimer levels, 98.7% of patients displaying elevated IL‑6 levels and 80.8% of patients displaying a reduced level of low‑density lipoprotein cholesterol (LDL‑C). In the present single‑center case study of 78 patients with COVID‑19 in Wuhan, China, the patients displayed abnormal routine blood tests, liver function, renal function and levels of D‑dimer, LDL‑C and IL‑6. Therefore, the development of drugs and vaccines that can be used to prevent and treat infections of COVID‑19 is urgently required.

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1	Wang C, Horby PW, Hayden FG and Gao GF: A novel coronavirus outbreak of global health concern. Lancet. 395:470–473. 2020.PubMed/NCBI View Article : Google Scholar
2	Jiang F, Deng L, Zhang L, Cai Y, Cheung CW and Xia Z: Review of the clinical characteristics of coronavirus disease 2019 (COVID-19). J Gen Intern Med. 35:1545–1549. 2020.PubMed/NCBI View Article : Google Scholar
3	Xu XW, Wu XX, Jiang XG, Xu KJ, Ying LJ, Ma CL, Li SB, Wang HY, Zhang S, Gao HN, et al: Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: Retrospective case series. BMJ. 368(m606)2020.PubMed/NCBI View Article : Google Scholar
4	World Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report-51, (urihttps://www.who.intsimplehttps://www.who.int).
5	World Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report-96, (urihttps://www.who.intsimplehttps://www.who.int).
6	Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, et al: Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 382:1708–1720. 2020.PubMed/NCBI View Article : Google Scholar
7	General Office of National Health Committee. Notice on the issuance of a program for the diagnosis and treatment of novel coronavirus (2019-nCoV) infected pneumonia (fourth trial version to sixth trial version). urihttp://www.nhc.gov.cn/jkj/new_index.htmlsimplehttp://www.nhc.gov.cn/jkj/new_index.html.
8	Badawi A and Ryoo SG: Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): A systematic review and meta-analysis. Int J Infect Dis. 49:129–133. 2016.PubMed/NCBI View Article : Google Scholar
9	Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, et al: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet. 395:507–513. 2020.PubMed/NCBI View Article : Google Scholar
10	Yang W, Cao Q, Qin L, Wang X, Cheng Z, Pan A, Dai J, Sun Q, Zhao F, Qu J and Yan F: Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): A multi-center study in Wenzhou city, Zhejiang, China. J Infect. 80:388–393. 2020.PubMed/NCBI View Article : Google Scholar
11	Ding Q, Lu P, Fan Y, Xia Y and Liu M: The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China. J Med Virol: March 20, 2020. 10.1002/jmv.25781, 2020.
12	Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, et al: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 395:497–506. 2020.PubMed/NCBI View Article : Google Scholar
13	Chinese Digestion Association, Chinese Medical Doctor Association; Chinese Society of Hepatology, Chinese Medical Association. The protocol for prevention, diagnosis and treatment of liver injury in coronavirus disease 2019. Zhonghua Gan Zang Bing Za Zhi. 28:217–221. 2020.PubMed/NCBI View Article : Google Scholar : (In Chinese).
14	Guan GW, Gao L, Wang JW, Wen XJ, Mao TH, Peng SW, Zhang T, Chen XM and Lu FM: Exploring the mechanism of liver enzyme abnormalities in patients with novel coronavirus-infected pneumonia. Zhonghua Gan Zang Bing Za Zhi. 28:100–106. 2020.PubMed/NCBI View Article : Google Scholar : (In Chinese).
15	Shlipak MG, Mattes MD and Peralta CA: Update on cystatin C: Incorporation into clinical practice. Am J Kidney Dis. 62:595–603. 2013.PubMed/NCBI View Article : Google Scholar
16	Menon V, Shlipak MG, Wang X, Coresh J, Greene T, Stevens L, Kusek JW, Beck GJ, Collins AJ, Levey AS and Sarnak MJ: Cystatin C as a risk factor for outcomes in chronic kidney disease. Ann Intern Med. 147:19–27. 2007.PubMed/NCBI View Article : Google Scholar
17	Sarnak MJ, Katz R, Stehman-Breen CO, Fried LF, Jenny NS, Psaty BM, Newman AB, Siscovick D and Shlipak MG: Cardiovascular Health Study. Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med. 142:497–505. 2005.PubMed/NCBI View Article : Google Scholar
18	Shlipak MG, Sarnak MJ, Katz R, Fried LF, Seliger SL, Newman AB, Siscovick DS and Stehman-Breen C: Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med. 352:2049–2060. 2005.PubMed/NCBI View Article : Google Scholar
19	Dolhnikoff M, Duarte-Neto AN, de Almeida Monteiro RA, da Silva LFF, de Oliveira EP, Saldiva PHN, Mauad T and Negri EM: Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19. J Thromb Haemost. 18:1517–1519. 2020.PubMed/NCBI View Article : Google Scholar
20	Zhang W, Zhao Y, Zhang F, Wang Q, Li T, Liu Z, Wang J, Qin Y, Zhang X, Yan X, et al: The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China. Clin Immunol. 214(108393)2020.PubMed/NCBI View Article : Google Scholar
21	Channappanavar R and Perlman S: Pathogenic human coronavirus infections: Causes and consequences of cytokine storm and immunopathology. Semin Immunopathol. 39:529–539. 2017.PubMed/NCBI View Article : Google Scholar
22	Chousterman BG, Swirski FK and Weber GF: Cytokine storm and sepsis disease pathogenesis. Semin Immunopathol. 39:517–528. 2017.PubMed/NCBI View Article : Google Scholar
23	Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, et al: Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 395:1054–1062. 2020.PubMed/NCBI View Article : Google Scholar
24	Ruan Q, Yang K, Wang W, Jiang L and Song J: Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 46:846–848. 2020.PubMed/NCBI View Article : Google Scholar
25	Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, Huang H, Zhang L, Zhou X, Du C, et al: Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 180:934–943. 2020.PubMed/NCBI View Article : Google Scholar
26	Radbel J, Narayanan N and Bhatt PJ: Use of tocilizumab for COVID-19-induced cytokine release syndrome: A cautionary case report. Chest. 158:e15–e19. 2020.PubMed/NCBI View Article : Google Scholar
27	Zhang S, Li L, Shen A, Chen Y and Qi Z: Rational use of tocilizumab in the treatment of novel coronavirus pneumonia. Clin Drug Investig. 40:511–518. 2020.PubMed/NCBI View Article : Google Scholar
28	Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Liu S, Zhao P, Liu H, Zhu L, et al: Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 8:420–422. 2020.PubMed/NCBI View Article : Google Scholar
29	Wei X, Zeng W, Su J, Wan H, Yu X, Cao X, Tan W and Wang H: Hypolipidemia is associated with the severity of COVID-19. J Clin Lipidol. 14:297–304. 2020.PubMed/NCBI View Article : Google Scholar
30	Funderburg NT and Mehta NN: Lipid abnormalities and inflammation in HIV inflection. Curr HIV/AIDS Rep. 13:218–225. 2016.PubMed/NCBI View Article : Google Scholar
31	Zidar DA, Juchnowski S, Ferrari B, Clagett B, Pilch-Cooper HA, Rose S, Rodriguez B, McComsey GA, Sieg SF, Mehta NN, et al: Oxidized LDL levels are increased in HIV infection and may drive monocyte activation. J Acquir Immune Defic Syndr. 69:154–160. 2015.PubMed/NCBI View Article : Google Scholar