Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2021 Volume 21 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2021 Volume 21 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

The expression and clinical significance of three lncRNAs in patients with a missed abortion

  • Authors:
    • Mei Luo
    • Huan Xiao
    • Liqiu Wang
    • Juan Zhao
    • Jie Gao
    • Wei Ma
  • View Affiliations / Copyright

    Affiliations: Central Laboratory, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China, Department of Gynecology and Obstetrics, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China, Department of Laboratory Medicine, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 8
    |
    Published online on: November 4, 2020
       https://doi.org/10.3892/etm.2020.9440
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Missed abortions are common complications that occur in early pregnancy, and impaired trophoblast functions have been indicated to be associated with their pathogenesis. The long noncoding RNAs (lncRNAs) Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1), HOX Transcript Antisense RNA (HOTAIR) and Maternally expressed gene 3 (MEG3) have been demonstrated to serve a crucial regulatory role in the mobility of trophoblast cells and embryo implantation. However, the expression profile and role of each of these three lncRNAs in patients with a missed abortion remain unclear. The expression of MALAT1, HOTAIR, and MEG3 in decidual and villous tissues from 26 patient exhibiting a missed abortion and 26 healthy controls was detected using reverse‑transcription quantitative PCR. Serum TNF‑α, IL‑1β, IL‑6 and IL‑10 levels were measured using ELISA, and serum estradiol and progesterone levels were measured with electrochemiluminescence immunoassays. Additionally, the correlations between lncRNA expression and the levels of cytokines and hormones were further analyzed. MALAT1, HOTAIR and MEG3 expression was significantly higher in villous tissues of patients exhibiting a missed abortion compared with healthy controls. MALAT1 expression was higher in decidual tissues of patients exhibiting a missed abortion compared with healthy controls. Serum IL‑10 levels were significantly lower in patients exhibiting a missed abortion compared with healthy controls. Serum estradiol and progesterone levels were significantly lower in the group of patients exhibiting a missed abortion compared with the control group. Furthermore, MALAT1 expression in villous tissue was inversely related to serum progesterone levels. The results of the current study suggest that MALAT1 may be associated with the pathogenesis of missed abortions.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Rai R and Regan L: Recurrent miscarriage. Lancet. 368:601–611. 2006.PubMed/NCBI View Article : Google Scholar

2 

Zhang X, Li J, Gu Y, Zhao Y, Wang Z and Jia G: A pilot study on environmental and behavioral factors related to missed abortion. Environ Health Prev Med. 16:273–278. 2011.PubMed/NCBI View Article : Google Scholar

3 

Griebel CP, Halvorsen J, Golemon TB and Day AA: Management of spontaneous abortion. Am Fam Physician. 72:1243–1250. 2005.PubMed/NCBI

4 

Fang J, Xie B, Chen B, Qiao C, Zheng B, Luan X, Liu J, Yan Y, Zheng Q, Wang M, et al: Biochemical clinical factors associated with missed abortion independent of maternal age: A retrospective study of 795 cases with missed abortion and 694 cases with normal pregnancy. Medicine (Baltimore). 97(e13573)2018.PubMed/NCBI View Article : Google Scholar

5 

Fu M, Mu S, Wen C, Jiang S, Li L, Meng Y and Peng H: Wholeexome sequencing analysis of products of conception identifies novel mutations associated with missed abortion. Mol Med Rep. 18:2027–2032. 2018.PubMed/NCBI View Article : Google Scholar

6 

Hwang JH, Kim JW, Hwang JY, Lee KM, Shim HM, Bae YK, Paik SS and Park H: Coxsackievirus B infection is highly related with missed abortion in Korea. Yonsei Med J. 55:1562–1567. 2014.PubMed/NCBI View Article : Google Scholar

7 

Wang Y, Zhang Y, Hu K, Qiu J, Hu Y, Zhou M and Zhang S: Elevated long noncoding RNA MALAT-1 expression is predictive of poor prognosis in patients with breast cancer: A meta-analysis. Biosci Rep. 40(BSR20200215)2020.PubMed/NCBI View Article : Google Scholar

8 

Liao K, Lin Y, Gao W, Xiao Z, Medina R, Dmitriev P, Cui J, Zhuang Z, Zhao X, Qiu Y, et al: Blocking lncRNA MALAT1/miR-199a/ZHX1 axis inhibits glioblastoma proliferation and progression. Mol Ther Nucleic Acids. 18:388–399. 2019.PubMed/NCBI View Article : Google Scholar

9 

Shen F, Zheng H, Zhou L, Li W and Xu X: Overexpression of MALAT1 contributes to cervical cancer progression by acting as a sponge of miR-429. J Cell Physiol. 234:11219–11226. 2019.PubMed/NCBI View Article : Google Scholar

10 

Gordon MA, Babbs B, Cochrane DR, Bitler BG and Richer JK: The long non-coding RNA MALAT1 promotes ovarian cancer progression by regulating RBFOX2-mediated alternative splicing. Mol Carcinog. 58:196–205. 2019.PubMed/NCBI View Article : Google Scholar

11 

Costanzo V, Bardelli A, Siena S and Abrignani S: Exploring the links between cancer and placenta development. Open Biol. 8(180081)2018.PubMed/NCBI View Article : Google Scholar

12 

Huppertz B: Traditional and new routes of trophoblast invasion and their implications for pregnancy diseases. Int J Mol Sci. 21(289)2019.PubMed/NCBI View Article : Google Scholar

13 

Brosens I, Puttemans P and Benagiano G: Placental bed research: I. The placental bed: from spiral arteries remodeling to the great obstetrical syndromes. Am J Obstet Gynecol. 221:437–456. 2019.PubMed/NCBI View Article : Google Scholar

14 

Geldenhuys J, Rossouw TM, Lombaard HA, Ehlers MM and Kock MM: Disruption in the regulation of immune responses in the placental subtype of preeclampsia. Front Immunol. 9(1659)2018.PubMed/NCBI View Article : Google Scholar

15 

McAninch D, Roberts CT and Bianco-Miotto T: Mechanistic Insight into Long Noncoding RNAs and the Placenta. Int J Mol Sci. 18(1371)2017.PubMed/NCBI View Article : Google Scholar

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

17 

Bouckenheimer J, Assou S, Riquier S, Hou C, Philippe N, Sansac C, Lavabre-Bertrand T, Commes T, Lemaître JM, Boureux A and De Vos J: Long non-coding RNAs in human early embryonic development and their potential in ART. Hum Reprod Update. 23:19–40. 2016.PubMed/NCBI View Article : Google Scholar

18 

Fang Z, Yang Y, Xu Y, Mai H, Zheng W, Pi L, Fu L, Zhou H, Tan Y, Che D and Gu X: LncRNA HULC polymorphism is associated with recurrent spontaneous abortion susceptibility in the southern chinese population. Front Genet. 10(918)2019.PubMed/NCBI View Article : Google Scholar

19 

Sheng F, Sun N, Ji Y, Ma Y, Ding H, Zhang Q, Yang F and Li W: Aberrant expression of imprinted lncRNA MEG8 causes trophoblast dysfunction and abortion. J Cell Biochem. 120:17378–17390. 2019.PubMed/NCBI View Article : Google Scholar

20 

Tian FJ, He XY, Wang J, Li X, Ma XL, Wu F, Zhang J, Liu XR, Qin XL, Zhang Y, et al: Elevated tristetraprolin impairs trophoblast invasion in women with recurrent miscarriage by destabilization of HOTAIR. Mol Ther Nucleic Acids. 12:600–609. 2018.PubMed/NCBI View Article : Google Scholar

21 

Chen Q, Jiang S, Liu H, Gao Y, Yang X, Ren Z, Gao Y, Xiao L, Hu H, Yu Y, et al: Association of lncRNA SH3PXD2A-AS1 with preeclampsia and its function in invasion and migration of placental trophoblast cells. Cell Death Dis. 11(583)2020.PubMed/NCBI View Article : Google Scholar

22 

Zhang Y, He XY, Qin S, Mo HQ, Li X, Wu F, Zhang J, Li X, Mao L, Peng YQ, et al: Upregulation of PUM1 expression in preeclampsia impairs trophoblast invasion by negatively regulating the expression of the lncRNA HOTAIR. Mol The. 28:631–641. 2020.PubMed/NCBI

23 

Gremlich S, Damnon F, Reymondin D, Braissant O, Schittny JC, Baud D, Gerber S and Roth-Kleiner M: The long non-coding RNA NEAT1 is increased in IUGR placentas, leading to potential new hypotheses of IUGR origin/development. Placenta. 35:44–49. 2014.PubMed/NCBI View Article : Google Scholar

24 

Wang R and Zou L: Downregulation of LncRNA-MEG3 promotes HTR8/SVneo cells apoptosis and attenuates its migration by repressing Notch1 signal in preeclampsia. Reproduction. 160:21–29. 2020.PubMed/NCBI View Article : Google Scholar

25 

Zhang Y, Qu L, Ni H, Wang Y, Li L, Yang X, Wang X and Hou Y: Expression and function of lncRNA MALAT1 in gestational diabetes mellitus. Adv Clin Exp Med. 29:903–910. 2020.PubMed/NCBI View Article : Google Scholar

26 

Zhang Y, Jin F, Li XC, Shen FJ, Ma XL, Wu F, Zhang SM, Zeng WH, Liu XR, Fan JX, et al: The YY1-HOTAIR-MMP2 signaling axis controls trophoblast invasion at the maternal-fetal interface. Mol Ther. 25:2394–2403. 2017.PubMed/NCBI View Article : Google Scholar

27 

Chen H, Meng T, Liu X, Sun M, Tong C, Liu J, Wang H and Du J: Long non-coding RNA MALAT-1 is downregulated in preeclampsia and regulates proliferation, apoptosis, migration and invasion of JEG-3 trophoblast cells. Int J Clin Exp Pathol. 8:12718–12727. 2015.PubMed/NCBI

28 

Tseng JJ, Hsieh YT, Hsu SL and Chou MM: Metastasis associated lung adenocarcinoma transcript 1 is up-regulated in placenta previa increta/percreta and strongly associated with trophoblast-like cell invasion in vitro. Mol Hum Reprod. 15:725–731. 2009.PubMed/NCBI View Article : Google Scholar

29 

Chen J, Ao L and Yang J: Long non-coding RNAs in diseases related to inflammation and immunity. Ann Transl Med. 7(494)2019.PubMed/NCBI View Article : Google Scholar

30 

Zou YF and Sun LZ: Long noncoding RNA HOTAIR modulates the function of trophoblast cells in pre-eclampsia. Sichuan Da Xue Xue Bao Yi Xue Ban. 46:113–122. 2015.PubMed/NCBI(In Chinese).

31 

Wu K, Liu F, Wu W, Chen Y, Wu H and Zhang W: Long non-coding RNA HOX transcript antisense RNA (HOTAIR) suppresses the angiogenesis of human placentation by inhibiting vascular endothelial growth factor A expression. Reprod Fertil Dev. 31:377–385. 2019.PubMed/NCBI View Article : Google Scholar

32 

Okada H, Tsuzuki T and Murata H: Decidualization of the human endometrium. Reprod Med Biol. 17:220–227. 2018.PubMed/NCBI View Article : Google Scholar

33 

Saito S, Nakashima A, Shima T and Ito M: Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol. 63:601–610. 2010.PubMed/NCBI View Article : Google Scholar

34 

Chaouat G, Zourbas S, Ostojic S, Lappree-Delage G, Dubanchet S, Ledee N and Martal J: A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy. J Reprod Immunol. 53:241–256. 2002.PubMed/NCBI View Article : Google Scholar

35 

Wang W, Lin Y, Zeng S and Li DJ: Improvement of fertility with adoptive CD25+ natural killer cell transfer in subfertile non-obese diabetic mice. Reprod Biomed Online. 18:95–103. 2009.PubMed/NCBI View Article : Google Scholar

36 

Lin Y, Zhong Y, Saito S, Chen Y, Shen W, Di J and Zeng S: Characterization of natural killer cells in nonobese diabetic/severely compromised immunodeficient mice during pregnancy. Fertil Steril. 91:2676–2686. 2009.PubMed/NCBI View Article : Google Scholar

37 

Lin Y, Wang H, Wang W, Zeng S, Zhong Y and Li DJ: Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2(+)ISG20(+) natural killer-cell transfer. Reproduction. 137:943–955. 2009.PubMed/NCBI View Article : Google Scholar

38 

Persson G, Bork JBS, Isgaard C, Larsen TG, Bordoy AM, Bengtsson MS and Hviid TVF: Cytokine stimulation of the choriocarcinoma cell line JEG-3 leads to alterations in the HLA-G expression profile. Cell Immunol. 352(104110)2020.PubMed/NCBI View Article : Google Scholar

39 

Trinchieri G: Interleukin-10 production by effector T cells: Th1 cells show self control. J Exp Med. 204:239–243. 2007.PubMed/NCBI View Article : Google Scholar

40 

Thaxton JE and Sharma S: Interleukin-10: A multi-faceted agent of pregnancy. Am J Reprod Immunol. 63:482–491. 2010.PubMed/NCBI View Article : Google Scholar

41 

Thaker R, Oza H, Verma V, Gor M and Kumar S: The association of circulatory cytokines (IL-6 and IL-10) level with spontaneous abortion-a preliminary observation. Reprod Sci: Aug 12, 2020 (Epub ahead of print).

42 

Danaii S, Ghorbani F, Ahmadi M, Abbaszadeh H, Koushaeian L, Soltani-Zangbar MS, Mehdizadeh A, Hojjat-Farsangi M, Kafil HS, Aghebati-Maleki L and Yousefi M: IL-10-producing B cells play important role in the pathogenesis of recurrent pregnancy loss. Int Immunopharmacol. 87(106806)2020.PubMed/NCBI View Article : Google Scholar

43 

Chitnis NS, Shieh M and Monos D: Regulatory noncoding RNAs and the major histocompatibility complex. Hum Immunol, 2020 (Epub ahead of print).

44 

Huang Z, Du G, Huang X, Han L, Han X, Xu B, Zhang Y, Yu M, Qin Y, Xia Y, et al: The enhancer RNA lnc-SLC4A1-1 epigenetically regulates unexplained recurrent pregnancy loss (URPL) by activating CXCL8 and NF-kB pathway. EBioMedicine. 38:162–170. 2018.PubMed/NCBI View Article : Google Scholar

45 

Ou M, Zhao H, Ji G, Zhao X and Zhang Q: Long noncoding RNA MALAT1 contributes to pregnancy-induced hypertension development by enhancing oxidative stress and inflammation through the regulation of the miR-150-5p/ET-1 axis. FASEB J. 34:6070–6085. 2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Luo M, Xiao H, Wang L, Zhao J, Gao J and Ma W: The expression and clinical significance of three lncRNAs in patients with a missed abortion. Exp Ther Med 21: 8, 2021.
APA
Luo, M., Xiao, H., Wang, L., Zhao, J., Gao, J., & Ma, W. (2021). The expression and clinical significance of three lncRNAs in patients with a missed abortion. Experimental and Therapeutic Medicine, 21, 8. https://doi.org/10.3892/etm.2020.9440
MLA
Luo, M., Xiao, H., Wang, L., Zhao, J., Gao, J., Ma, W."The expression and clinical significance of three lncRNAs in patients with a missed abortion". Experimental and Therapeutic Medicine 21.1 (2021): 8.
Chicago
Luo, M., Xiao, H., Wang, L., Zhao, J., Gao, J., Ma, W."The expression and clinical significance of three lncRNAs in patients with a missed abortion". Experimental and Therapeutic Medicine 21, no. 1 (2021): 8. https://doi.org/10.3892/etm.2020.9440
Copy and paste a formatted citation
x
Spandidos Publications style
Luo M, Xiao H, Wang L, Zhao J, Gao J and Ma W: The expression and clinical significance of three lncRNAs in patients with a missed abortion. Exp Ther Med 21: 8, 2021.
APA
Luo, M., Xiao, H., Wang, L., Zhao, J., Gao, J., & Ma, W. (2021). The expression and clinical significance of three lncRNAs in patients with a missed abortion. Experimental and Therapeutic Medicine, 21, 8. https://doi.org/10.3892/etm.2020.9440
MLA
Luo, M., Xiao, H., Wang, L., Zhao, J., Gao, J., Ma, W."The expression and clinical significance of three lncRNAs in patients with a missed abortion". Experimental and Therapeutic Medicine 21.1 (2021): 8.
Chicago
Luo, M., Xiao, H., Wang, L., Zhao, J., Gao, J., Ma, W."The expression and clinical significance of three lncRNAs in patients with a missed abortion". Experimental and Therapeutic Medicine 21, no. 1 (2021): 8. https://doi.org/10.3892/etm.2020.9440
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team