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Interleukin‑6 signaling blockade treatment for cytokine release syndrome in COVID‑19 (Review)

  • Authors:
    • Jia-Jie Chen
    • Li-Na Zhang
    • Hu Hou
    • Lingqing Xu
    • Kunmei Ji
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Health Science Center of Shenzhen University, Shenzhen, Guangdong 518060, P.R. China, Department of Clinical Laboratory, Shenzhen People's Hospital, Shenzhen, Guangdong 518020, P.R. China, Department of Clinical Laboratory, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, Guangdong 511518, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 24
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    Published online on: November 9, 2020
       https://doi.org/10.3892/etm.2020.9456
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Abstract

A severe immune response in patients with coronavirus disease 2019 (COVID‑19) can cause a potentially lethal unconstrained inflammatory cytokine storm, known as cytokine release syndrome (CRS). The present study provides an overview of the biology underlying CRS and how targeted inhibition of interleukin (IL)‑6 signaling may improve outcomes and the survival of patients suffering from COVID‑19. Preliminary clinical results have indicated that antagonism of the IL‑6 receptor (IL‑6R), including with the FDA‑approved humanized monoclonal antibody tocilizumab, can improve the outcomes of patients with severe or critical COVID‑19 while maintaining a good safety profile. The available clinical data support the expansion of clinical trials using IL‑6R targeting inhibitors for severe and critical COVID‑19 treatment.
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1 

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, et al: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 395:497–506. 2020.PubMed/NCBI View Article : Google Scholar

2 

Wang C, Horby PW, Hayden FG and Gao GF: A novel coronavirus outbreak of global health concern. Lancet. 395:470–473. 2020.PubMed/NCBI View Article : Google Scholar

3 

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, et al: Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 323:1061–1069. 2020.PubMed/NCBI View Article : Google Scholar

4 

Prompetchara E, Ketloy C and Palaga T: Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. Asian Pac J Allergy Immunol. 38:1–9. 2020.PubMed/NCBI View Article : Google Scholar

5 

Channappanavar R and Perlman S: Pathogenic human coronavirus infections: Causes and consequences of cytokine storm and immunopathology. Semin Immunopathol. 39:529–539. 2017.PubMed/NCBI View Article : Google Scholar

6 

Wang Y, Wang Y, Chen Y and Qin Q: Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures. J Med Virol. 92:568–576. 2020.PubMed/NCBI View Article : Google Scholar

7 

Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Liu S, Zhao P, Liu H, Zhu L, et al: Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 8:420–422. 2020.PubMed/NCBI View Article : Google Scholar

8 

Teachey DT, Lacey SF, Shaw PA, Melenhorst JJ, Maude SL, Frey N, Pequignot E, Gonzalez VE, Chen F, Finklestein J, et al: Identification of predictive biomarkers for cytokine release syndrome after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Cancer Discov. 6:664–679. 2016.PubMed/NCBI View Article : Google Scholar

9 

Zhang Y, Li J, Zhan Y, Wu L, Yu X, Zhang W, Ye L, Xu S, Sun R, Wang Y and Lou J: Analysis of serum cytokines in patients with severe acute respiratory syndrome. Infect Immun. 72:4410–4415. 2004.PubMed/NCBI View Article : Google Scholar

10 

Norelli M, Camisa B, Barbiera G, Falcone L, Purevdorj A, Genua M, Sanvito F, Ponzoni M, Doglioni C, Cristofori P, et al: Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells. Nat Med. 24:739–748. 2018.PubMed/NCBI View Article : Google Scholar

11 

Schmidt-Arras D and Rose-John S: IL-6 pathway in the liver: From physiopathology to therapy. J Hepatol. 64:1403–1415. 2016.PubMed/NCBI View Article : Google Scholar

12 

Baran P, Hansen S, Waetzig GH, Akbarzadeh M, Lamertz L, Huber HJ, Ahmadian MR, Moll JM and Scheller J: The balance of interleukin (IL)-6, IL-6.soluble IL-6 receptor (sIL-6R), and IL-6.sIL-6R.sgp130 complexes allows simultaneous classic and trans-signaling. J Biol Chem. 293:6762–6775. 2018.PubMed/NCBI View Article : Google Scholar

13 

Rose-John S: IL-6 trans-signaling via the soluble IL-6 receptor: Importance for the pro-inflammatory activities of IL-6. Int J Biol Sci. 8:1237–1247. 2012.PubMed/NCBI View Article : Google Scholar

14 

Banerjee K and Resat H: Constitutive activation of STAT3 in breast cancer cells: A review. Int J Cancer. 138:2570–2578. 2016.PubMed/NCBI View Article : Google Scholar

15 

Johnson DE, O'Keefe RA and Grandis JR: Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 15:234–248. 2018.PubMed/NCBI View Article : Google Scholar

16 

Deisseroth A, Ko CW, Nie L, Zirkelbach JF, Zhao L, Bullock J, Mehrotra N, Del Valle P, Saber H, Sheth C, et al: FDA approval: Siltuximab for the treatment of patients with multicentric castleman disease. Clin Cancer Res. 21:950–954. 2015.PubMed/NCBI View Article : Google Scholar

17 

Yamamura T, Kleiter I, Fujihara K, Palace J, Greenberg B, Zakrzewska-Pniewska B, Patti F, Tsai CP, Saiz A, Yamazaki H, et al: Trial of satralizumab in neuromyelitis optica spectrum disorder. N Engl J Med. 381:2114–2124. 2019.PubMed/NCBI View Article : Google Scholar

18 

Tanaka T, Narazaki M and Kishimoto T: IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 6(a016295)2014.PubMed/NCBI View Article : Google Scholar

19 

McGonagle D, Sharif K, O'Regan A and Bridgewood C: The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease. Autoimmun Rev. 19(102537)2020.PubMed/NCBI View Article : Google Scholar

20 

Matthews VB, Allen TL, Risis S, Chan MH, Henstridge DC, Watson N, Zaffino LA, Babb JR, Boon J, Meikle PJ, et al: Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance. Diabetologia. 53:2431–2441. 2010.PubMed/NCBI View Article : Google Scholar

21 

Navarro G, Taroumian S, Barroso N, Duan L and Furst D: Tocilizumab in rheumatoid arthritis: A meta-analysis of efficacy and selected clinical conundrums. Semin Arthritis Rheum. 43:458–469. 2014.PubMed/NCBI View Article : Google Scholar

22 

Le RQ, Li L, Yuan W, Shord SS, Nie L, Habtemariam BA, Przepiorka D, Farrell AT and Pazdur R: FDA approval summary: Tocilizumab for treatment of chimeric antigen receptor T cell-induced severe or life-threatening cytokine release syndrome. Oncologist. 23:943–947. 2018.PubMed/NCBI View Article : Google Scholar

23 

Jones SA, Richards PJ, Scheller J and Rose-John S: IL-6 transsignaling: The in vivo consequences. J Interferon Cytokine Res. 25:241–253. 2005.PubMed/NCBI View Article : Google Scholar

24 

Kaly L and Rosner I: Tocilizumab-a novel therapy for non-organ-specific autoimmune diseases. Best Pract Res Clin Rheumatol. 26:157–165. 2012.PubMed/NCBI View Article : Google Scholar

25 

Yokota S, Imagawa T, Mori M, Miyamae T, Aihara Y, Takei S, Iwata N, Umebayashi H, Murata T, Miyoshi M, et al: Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: A randomised, double-blind, placebo-controlled, withdrawal phase III trial. Lancet. 371:998–1006. 2008.PubMed/NCBI View Article : Google Scholar

26 

Gabay C, Emery P, van Vollenhoven R, Dikranian A, Alten R, Pavelka K, Klearman M, Musselman D, Agarwal S, Green J, et al: Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): A randomised, double-blind, controlled phase 4 trial. Lancet. 381:1541–1550. 2013.PubMed/NCBI View Article : Google Scholar

27 

Yanaihara N, Hirata Y, Yamaguchi N, Noguchi Y, Saito M, Nagata C, Takakura S, Yamada K and Okamoto A: Antitumor effects of interleukin-6 (IL-6)/interleukin-6 receptor (IL-6R) signaling pathway inhibition in clear cell carcinoma of the ovary. Mol Carcinog. 55:832–841. 2016.PubMed/NCBI View Article : Google Scholar

28 

Goumas FA, Holmer R, Egberts JH, Gontarewicz A, Heneweer C, Geisen U, Hauser C, Mende MM, Legler K, Röcken C, et al: Inhibition of IL-6 signaling significantly reduces primary tumor growth and recurrencies in orthotopic xenograft models of pancreatic cancer. Int J Cancer. 137:1035–1046. 2015.PubMed/NCBI View Article : Google Scholar

29 

Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L and Karin M: IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 15:103–113. 2009.PubMed/NCBI View Article : Google Scholar

30 

Dijkgraaf EM, Santegoets SJ, Reyners AK, Goedemans R, Wouters MC, Kenter GG, van Erkel AR, van Poelgeest MI, Nijman HW, van der Hoeven JJ, et al: A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-alpha2b in patients with recurrent epithelial ovarian cancer. Ann Oncol. 26:2141–2149. 2015.PubMed/NCBI View Article : Google Scholar

31 

Zhou Y, Fu B, Zheng X, Wang D, Zhao C, Qi Y, Sun R, Tian Z, Xu X and Wei H: Aberrant pathogenic GM-CSF+T cells and inflammatory CD14+ CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus. bioRxiv. Feb 20, 2020 doi: urihttps://doi.org/10.1101/2020.02.12.945576simplehttps://doi.org/10.1101/2020.02.12.945576.

32 

Xu X, Han M, Li T, Sun W, Wang D, Fu B, Zhou Y, Zheng X, Yang Y, Li X, et al: Effective treatment of severe COVID-19 patients with tocilizumab. Proc Natl Acad Sci USA. 117:10970–10975. 2020.PubMed/NCBI View Article : Google Scholar

33 

Price CC, Altice FL, Shyr Y, Koff A, Pischel L, Goshua G, Azar MM, Mcmanus D, Chen SC, Gleeson SE, et al: Tocilizumab treatment for cytokine release syndrome in hospitalized COVID-19 patients: Survival and clinical outcomes. Chest: 15 Jun, 2020 doi: 10.1016/j.chest.2020.06.006 (Epub ahead for print).

34 

Toniati P, Piva S, Cattalini M, Garrafa E, Regola F, Castelli F, Franceschini F, Airò P, Bazzani C, Beindorf EA, et al: Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: A single center study of 100 patients in Brescia, Italy. Autoimmun Rev. 19(102568)2020.PubMed/NCBI View Article : Google Scholar

35 

Kewan T, Covut F, Al-Jaghbeer MJ, Rose L, Gopalakrishna KV and Akbik B: Tocilizumab for treatment of patients with severe COVID-19: A retrospective cohort study. EClinicalMedicine. 24(100418)2020.PubMed/NCBI View Article : Google Scholar

36 

Eimer J, Vesterbacka J, Svensson AK, Stojanovic B, Wagrell C, Sonnerborg A and Nowak P: Tocilizumab shortens time on mechanical ventilation and length of hospital stay in patients with severe COVID-19: A retrospective cohort study. J Intern Med: Aug 3, 2020 doi: 10.1111/joim.13162 (Epub ahead for print).

37 

Potere N, Di Nisio M, Rizzo G, La Vella M, Polilli E, Agostinone A, Spacone A, Di Carlo S, Costantini A, Abbate A, et al: Low-dose subcutaneous tocilizumab to prevent disease progression in patients with moderate COVID-19 pneumonia and hyperinflammation. Int J Infect Dis: Aug 5, 2020 doi: 10.1016/j.ijid.2020.07.078 (Epub ahead for print).

38 

Arthritis drug shows ‘significant’ promise in severe COVID-19 cases: Study (2020, April 28) urihttps://medicalxpress.com/news/2020-04-arthritis-drug-significant-severe-covid-.htmlsimplehttps://medicalxpress.com/news/2020-04-arthritis-drug-significant-severe-covid-.html. Accessed 30 May 2020.

39 

Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (7th Interim edition). China NHCOTPSRO. urihttp://www.nhc.gov.cn/yzygj/s7653p/202003/46c9294a7dfe4cef80dc7f5912eb1989/files/ce3e6945832a438eaae415350a8ce964.pdfsimplehttp://www.nhc.gov.cn/yzygj/s7653p/202003/46c9294a7dfe4cef80dc7f5912eb1989/files/ce3e6945832a438eaae415350a8ce964.pdf. Accessed 30 May 2020.

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Spandidos Publications style
Chen J, Zhang L, Hou H, Xu L and Ji K: Interleukin‑6 signaling blockade treatment for cytokine release syndrome in COVID‑19 (Review). Exp Ther Med 21: 24, 2021.
APA
Chen, J., Zhang, L., Hou, H., Xu, L., & Ji, K. (2021). Interleukin‑6 signaling blockade treatment for cytokine release syndrome in COVID‑19 (Review). Experimental and Therapeutic Medicine, 21, 24. https://doi.org/10.3892/etm.2020.9456
MLA
Chen, J., Zhang, L., Hou, H., Xu, L., Ji, K."Interleukin‑6 signaling blockade treatment for cytokine release syndrome in COVID‑19 (Review)". Experimental and Therapeutic Medicine 21.1 (2021): 24.
Chicago
Chen, J., Zhang, L., Hou, H., Xu, L., Ji, K."Interleukin‑6 signaling blockade treatment for cytokine release syndrome in COVID‑19 (Review)". Experimental and Therapeutic Medicine 21, no. 1 (2021): 24. https://doi.org/10.3892/etm.2020.9456
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Zhang L, Hou H, Xu L and Ji K: Interleukin‑6 signaling blockade treatment for cytokine release syndrome in COVID‑19 (Review). Exp Ther Med 21: 24, 2021.
APA
Chen, J., Zhang, L., Hou, H., Xu, L., & Ji, K. (2021). Interleukin‑6 signaling blockade treatment for cytokine release syndrome in COVID‑19 (Review). Experimental and Therapeutic Medicine, 21, 24. https://doi.org/10.3892/etm.2020.9456
MLA
Chen, J., Zhang, L., Hou, H., Xu, L., Ji, K."Interleukin‑6 signaling blockade treatment for cytokine release syndrome in COVID‑19 (Review)". Experimental and Therapeutic Medicine 21.1 (2021): 24.
Chicago
Chen, J., Zhang, L., Hou, H., Xu, L., Ji, K."Interleukin‑6 signaling blockade treatment for cytokine release syndrome in COVID‑19 (Review)". Experimental and Therapeutic Medicine 21, no. 1 (2021): 24. https://doi.org/10.3892/etm.2020.9456
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