1
|
Wang H, Fu H, Zhu R, Wu X, Ji X, Li X,
Jiang H, Lin Z, Tang X, Sun S, et al: BRD4 contributes to
LPS-induced macrophage senescence and promotes progression of
atherosclerosis-associated lipid uptake. Aging (Albany NY).
12:9240–9259. 2020.PubMed/NCBI View Article : Google Scholar
|
2
|
Del Pinto R, Grassi D, Properzi G,
Desideri G and Ferri C: Low density lipoprotein (LDL) cholesterol
as a causal role for atherosclerotic disease: Potential role of
PCSK9 inhibitors. High Blood Press Cardiovasc Prev. 26:199–207.
2019.PubMed/NCBI View Article : Google Scholar
|
3
|
Tian K, Ogura S, Little PJ, Xu SW and
Sawamura T: Targeting LOX-1 in atherosclerosis and vasculopathy:
Current knowledge and future perspectives. Ann N Y Acad Sci.
1443:34–53. 2019.PubMed/NCBI View Article : Google Scholar
|
4
|
Ding Z, Liu S, Wang X, Deng X, Fan Y,
Shahanawaz J, Shmookler Reis RJ, Varughese KI, Sawamura T and Mehta
JL: Cross-talk between LOX-1 and PCSK9 in vascular tissues.
Cardiovasc Res. 107:556–567. 2015.PubMed/NCBI View Article : Google Scholar
|
5
|
Kattoor AJ, Pothineni NVK, Palagiri D and
Mehta JL: Oxidative stress in atherosclerosis. Curr Atheroscler
Rep. 19(42)2017.PubMed/NCBI View Article : Google Scholar
|
6
|
Shimizu I and Minamino T: Cellular
senescence in cardiac diseases. J Cardiol. 74:313–319.
2019.PubMed/NCBI View Article : Google Scholar
|
7
|
Ding Z, Liu S, Wang X, Deng X, Fan Y, Sun
C, Wang Y and Mehta JL: Hemodynamic shear stress via ROS modulates
PCSK9 expression in human vascular endothelial and smooth muscle
cells and along the mouse aorta. Antioxid Redox Signal. 22:760–771.
2015.PubMed/NCBI View Article : Google Scholar
|
8
|
Grobelna MK, Strauss E and Krasiński Z:
The role of proprotein convertase subtilisin-kexin type 9 (PCSK9)
in the vascular aging process-is there a link? Kardiochir
Torakochirurgia Pol. 16:128–132. 2019.PubMed/NCBI View Article : Google Scholar
|
9
|
Pal HC, Pearlman RL and Afaq F: Fisetin
and Its role in chronic diseases. Adv Exp Med Biol. 928:213–244.
2016.PubMed/NCBI View Article : Google Scholar
|
10
|
Jin T, Kim OY, Shin MJ, Choi EY, Lee SS,
Han YS and Chung JH: Fisetin up-regulates the expression of
adiponectin in 3T3-L1 adipocytes via the activation of silent
mating type information regulation 2 homologue 1
(SIRT1)-deacetylase and peroxisome proliferator-activated receptors
(PPARs). J Agric Food Chem. 62:10468–10474. 2014.PubMed/NCBI View Article : Google Scholar
|
11
|
Shi YS, Li CB, Li XY, Wu J, Li Y, Fu X,
Zhang Y and Hu WZ: Fisetin attenuates metabolic dysfunction in mice
challenged with a high-fructose diet. J Agric Food Chem.
66:8291–8298. 2018.PubMed/NCBI View Article : Google Scholar
|
12
|
Yousefzadeh MJ, Zhu Y, McGowan SJ,
Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI,
Pirtskhalava T, Inman CL, et al: Fisetin is a senotherapeutic that
extends health and lifespan. EBioMedicine. 36:18–28.
2018.PubMed/NCBI View Article : Google Scholar
|
13
|
Jia Q, Cao H, Shen D, Yan L, Chen C and
Xing S: Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid
accumulation and senescence in RAW264.7 macrophage-derived foam
cells. Eur J Pharmacol. 865(172748)2019.PubMed/NCBI View Article : Google Scholar
|
14
|
Summerhill VI, Grechko AV, Yet SF, Sobenin
IA and Orekhov AN: The atherogenic role of circulating modified
lipids in atherosclerosis. Int J Mol Sci. 20(3561)2019.PubMed/NCBI View Article : Google Scholar
|
15
|
Wu NQ and Li JJ: PCSK9 gene mutations and
low-density lipoprotein cholesterol. Clin Chim Acta. 431:148–153.
2014.PubMed/NCBI View Article : Google Scholar
|
16
|
Kumar S, Kang DW, Rezvan A and Jo H:
Accelerated atherosclerosis development in C57Bl6 mice by
overexpressing AAV-mediated PCSK9 and partial carotid ligation. Lab
Invest. 97:935–945. 2017.PubMed/NCBI View Article : Google Scholar
|
17
|
Sun H, Krauss RM, Chang JT and Teng BB:
PCSK9 deficiency reduces atherosclerosis, apolipoprotein B
secretion, and endothelial dysfunction. J Lipid Res. 59:207–223.
2018.PubMed/NCBI View Article : Google Scholar
|
18
|
Hilvo M, Simolin H, Metso J, Ruuth M,
Öörni K, Jauhiainen M, Laaksonen R and Baruch A: PCSK9 inhibition
alters the lipidome of plasma and lipoprotein fractions.
Atherosclerosis. 269:159–165. 2018.PubMed/NCBI View Article : Google Scholar
|
19
|
Xu S, Ogura S, Chen J, Little PJ, Moss J
and Liu P: LOX-1 in atherosclerosis: Biological functions and
pharmacological modifiers. Cell Mol Life Sci. 70:2859–2872.
2013.PubMed/NCBI View Article : Google Scholar
|
20
|
Akhmedov A, Rozenberg I, Paneni F, Camici
GG, Shi Y, Doerries C, Sledzinska A, Mocharla P, Breitenstein A,
Lohmann C, et al: Endothelial overexpression of LOX-1 increases
plaque formation and promotes atherosclerosis in vivo. Eur Heart J.
35:2839–2848. 2014.PubMed/NCBI View Article : Google Scholar
|
21
|
Dai Y, Wu X, Dai D, Li J and Mehta JL:
MicroRNA-98 regulates foam cell formation and lipid accumulation
through repression of LOX-1. Redox Biol. 16:255–262.
2018.PubMed/NCBI View Article : Google Scholar
|
22
|
Ding Z, Liu S, Wang X, Theus S, Deng X,
Fan Y, Zhou S and Mehta JL: PCSK9 regulates expression of scavenger
receptors and ox-LDL uptake in macrophages. Cardiovasc Res.
114:1145–1153. 2018.PubMed/NCBI View Article : Google Scholar
|
23
|
Fajemiroye JO, da Cunha LC,
Saavedra-Rodríguez R, Rodrigues KL, Naves LM, Mourão AA, da Silva
EF, Williams NEE, Martins JLR, Sousa RB, et al: Aging-induced
biological changes and cardiovascular diseases. Biomed Res Int.
2018(7156435)2018.PubMed/NCBI View Article : Google Scholar
|
24
|
Dzięgielewska-Gęsiak S, Płóciniczak A,
Wilemska-Kucharzewska K, Kokot T, Muc-Wierzgoń M and Wysocka E: The
relationship between plasma lipids, oxidant-antioxidant status, and
glycated proteins in individuals at risk for atherosclerosis. Clin
Interv Aging. 14:789–796. 2019.PubMed/NCBI View Article : Google Scholar
|
25
|
Wang Y, Branicky R, Noë A and Hekimi S:
Superoxide dismutases: Dual roles in controlling ROS damage and
regulating ROS signaling. J Cell Biol. 217:1915–1928.
2018.PubMed/NCBI View Article : Google Scholar
|
26
|
Papac-Milicevic N, Busch CJ and Binder CJ:
Malondialdehyde epitopes as targets of immunity and the
implications for atherosclerosis. Adv Immunol. 131:1–59.
2016.PubMed/NCBI View Article : Google Scholar
|
27
|
Zhou Z, Yin Y, Chang Q, Sun G and Dai Y:
Downregulation of B-myb promotes senescence via the ROS-mediated
p53/p21 pathway, in vascular endothelial cells. Cell Prolif.
50(e12319)2017.PubMed/NCBI View Article : Google Scholar
|
28
|
Adorni MP, Ruscica M, Ferri N, Bernini F
and Zimetti F: Proprotein convertase subtilisin/kexin type 9, brain
cholesterol homeostasis and potential implication for Alzheimer's
disease. Front Aging Neurosci. 11(120)2019.PubMed/NCBI View Article : Google Scholar
|
29
|
Wang X, Khaidakov M, Ding Z, Dai Y,
Mercanti F and Mehta JL: LOX-1 in the maintenance of cytoskeleton
and proliferation in senescent cardiac fibroblasts. J Mol Cell
Cardiol. 60:184–190. 2013.PubMed/NCBI View Article : Google Scholar
|
30
|
Gaballah HH, El-Horany HE and Helal DS:
Mitigative effects of the bioactive flavonol fisetin on
high-fat/high-sucrose induced nonalcoholic fatty liver disease in
rats. J Cell Biochem. 120:12762–12774. 2019.PubMed/NCBI View Article : Google Scholar
|
31
|
Singh S, Singh AK, Garg G and Rizvi SI:
Fisetin as a caloric restriction mimetic protects rat brain against
aging induced oxidative stress, apoptosis and neurodegeneration.
Life Sci. 193:171–179. 2018.PubMed/NCBI View Article : Google Scholar
|
32
|
Zhang L, Wang H, Zhou Y, Zhu Y and Fei M:
Fisetin alleviates oxidative stress after traumatic brain injury
via the Nrf2-ARE pathway. Neurochem Int. 118:304–313.
2018.PubMed/NCBI View Article : Google Scholar
|
33
|
Lian TW, Wang L, Lo YH, Huang IJ and Wu
MJ: Fisetin, morin and myricetin attenuate CD36 expression and
oxLDL uptake in U937-derived macrophages. Biochim Biophys Acta.
1781:601–609. 2008.PubMed/NCBI View Article : Google Scholar
|
34
|
Jung CH, Kim H, Ahn J, Jeon TI, Lee DH and
Ha TY: Fisetin regulates obesity by targeting mTORC1 signaling. J
Nutr Biochem. 24:1547–1554. 2013.PubMed/NCBI View Article : Google Scholar
|
35
|
Patel R, Varghese JF, Singh RP and Yadav
UCS: Induction of endothelial dysfunction by oxidized low-density
lipoproteins via downregulation of Erk-5/Mef2c/KLF2 signaling:
Amelioration by fisetin. Biochimie. 163:152–162. 2019.PubMed/NCBI View Article : Google Scholar
|
36
|
Shin MJ, Cho Y, Moon J, Jeon HJ, Lee SM
and Chung JH: Hypocholesterolemic effect of daily fisetin
supplementation in high fat fed sprague-dawley rats. Food Chem
Toxicol. 57:84–90. 2013.PubMed/NCBI View Article : Google Scholar
|
37
|
Sun Q, Zhang W, Zhong W, Sun X and Zhou Z:
Dietary fisetin supplementation protects against alcohol-induced
liver injury in mice. Alcohol Clin Exp Res. 40:2076–2084.
2016.PubMed/NCBI View Article : Google Scholar
|
38
|
Prasath GS and Subramanian SP:
Antihyperlipidemic effect of fisetin, a bioflavonoid of
strawberries, studied in streptozotocin-induced diabetic rats. J
Biochem Mol Toxicol. 28:442–449. 2014.PubMed/NCBI View Article : Google Scholar
|
39
|
Zhu Y, Doornebal EJ, Pirtskhalava T,
Giorgadze N, Wentworth M, Fuhrmann-Stroissnigg H, Niedernhofer LJ,
Robbins PD, Tchkonia T and Kirkland JL: New agents that target
senescent cells: The flavone, fisetin, and the BCL-XL inhibitors,
A1331852 and A1155463. Aging (Albany NY). 9:955–963.
2017.PubMed/NCBI View Article : Google Scholar
|
40
|
Currais A, Farrokhi C, Dargusch R, Armando
A, Quehenberger O, Schubert D and Maher P: Fisetin reduces the
impact of aging on behavior and physiology in the rapidly aging
SAMP8 mouse. J Gerontol A Biol Sci Med Sci. 73:299–307.
2018.PubMed/NCBI View Article : Google Scholar
|
41
|
Singh S, Garg G, Singh AK, Bissoyi A and
Rizvi SI: Fisetin, a potential caloric restriction mimetic,
attenuates senescence biomarkers in rat erythrocytes. Biochem Cell
Biol. 97:480–487. 2019.PubMed/NCBI View Article : Google Scholar
|
42
|
Wood JG, Rogina B, Lavu S, Howitz K,
Helfand SL, Tatar M and Sinclair D: Sirtuin activators mimic
caloric restriction and delay ageing in metazoans. Nature.
430:686–689. 2004.PubMed/NCBI View Article : Google Scholar
|
43
|
Ma T, Kandhare AD, Mukherjee-Kandhare AA
and Bodhankar SL: Fisetin, a plant flavonoid ameliorates
doxorubicin-induced cardiotoxicity in experimental rats: The
decisive role of caspase-3, COX-II, cTn-I, iNOs and TNF-α. Mol Biol
Rep. 46:105–118. 2019.PubMed/NCBI View Article : Google Scholar
|
44
|
Krasieva TB, Ehren J, O'Sullivan T,
Tromberg BJ and Maher P: Cell and brain tissue imaging of the
flavonoid fisetin using label-free two-photon microscopy. Neurochem
Int. 89:243–248. 2015.PubMed/NCBI View Article : Google Scholar
|
45
|
Varela-Rodríguez L, Sánchez-Ramírez B,
Rodríguez-Reyna IS, Ordaz-Ortiz JJ, Chávez-Flores D, Salas-Muñoz E,
Osorio-Trujillo JC, Ramos-Martínez E and Talamás-Rohana P:
Biological and toxicological evaluation of Rhus trilobata Nutt.
(Anacardiaceae) used traditionally in Mexico against cancer. BMC
Complement Altern Med. 19(153)2019.PubMed/NCBI View Article : Google Scholar
|